Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.

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🔗 View Article (PMID 26359337)

Published in Science on September 10, 2015

Authors

Eliezer M Van Allen1,2,3, Diana Miao1,2, Bastian Schilling4,5, Sachet A Shukla1,2, Christian Blank6, Lisa Zimmer4,5, Antje Sucker4,5, Uwe Hillen4,5, Marnix H Geukes Foppen6, Simone M Goldinger7, Jochen Utikal5,8,9, Jessica C Hassel10, Benjamin Weide11, Katharina C Kaehler12, Carmen Loquai13, Peter Mohr14, Ralf Gutzmer15, Reinhard Dummer7, Stacey Gabriel2, Catherine J Wu1,2, Dirk Schadendorf4,5, Levi A Garraway1,2,3

Author Affiliations

1: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
2: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
3: Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
4: Department of Dermatology, University Hospital, University Duisburg-Essen, 45147 Essen, Germany.
5: German Cancer Consortium (DKTK), 69121 Heidelberg, Germany.
6: Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
7: Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
8: Skin Cancer Unit, German Cancer Research Center(DKTK), 69121 Heidelberg, Germany.
9: Department of Dermatology, Venerology, and Allergology, University Medical Center, Ruprecht-Karls University of Heidelberg, 68167 Mannheim, Germany.
10: Department of Dermatology, University Hospital, Ruprecht-Karls University of Heidelberg, 69120 Heidelberg, Germany.
11: Department of Dermatology, University Hospital Tübingen, 72076 Tübingen, Germany.
12: Department of Dermatology, University Hospital Kiel, 24105 Kiel, Germany.
13: Department of Dermatology, University Medical Center, 55131 Mainz, Germany.
14: Department of Dermatology, Elbe-Kliniken, 21614 Buxtehude, Germany.
15: Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, 30625 Hannover, Germany.

Associated clinical trials:

Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity (CAPTIV-8) | NCT04273061

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