Advances in immunotherapy for melanoma.

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🔗 View Article (PMID 26850630)

Published in BMC Med on February 06, 2016

Authors

Jason M Redman1,2, Geoffrey T Gibney3,4, Michael B Atkins5,6

Author Affiliations

1: Georgetown Lombardi Comprehensive Cancer Center 3970 Reservoir Road, NW Research Building, Room E501, 20007, Washington DC, USA. jason.m.redman@gmail.com.
2: Department of Medicine, Georgetown University Medical Center, Washington DC, USA. jason.m.redman@gmail.com.
3: Georgetown Lombardi Comprehensive Cancer Center 3970 Reservoir Road, NW Research Building, Room E501, 20007, Washington DC, USA. geoffrey.t.gibney@gunet.georgetown.edu.
4: Department of Medicine, Georgetown University Medical Center, Washington DC, USA. geoffrey.t.gibney@gunet.georgetown.edu.
5: Georgetown Lombardi Comprehensive Cancer Center 3970 Reservoir Road, NW Research Building, Room E501, 20007, Washington DC, USA. mba41@georgetown.edu.
6: Department of Medicine, Georgetown University Medical Center, Washington DC, USA. mba41@georgetown.edu.

Associated clinical trials:

Safety Study of Anti-LAG-3 With and Without Anti-PD-1 in the Treatment of Solid Tumors | NCT01968109

Phase 3 Trial in Subjects With Metastatic Melanoma Comparing 3 mg/kg Ipilimumab Versus 10 mg/kg Ipilimumab | NCT01515189

A Study Of 4-1BB Agonist PF-05082566 Plus PD-1 Inhibitor MK-3475 In Patients With Solid Tumors (B1641003/KEYNOTE-0036) | NCT02179918

Pembrolizumab With or Without Talimogene Laherparepvec or Talimogene Laherparepvec Placebo in Unresected Melanoma | NCT02263508

Safety and Tolerability of Pembrolizumab (MK-3475) + Pegylated Interferon Alfa-2b and Pembrolizumab+ Ipilimumab in Participants With Advanced Melanoma or Renal Cell Carcinoma (MK-3475-029/KEYNOTE-29) | NCT02089685

A Phase 1 Study to Evaluate MEDI6383 Alone and in Combination With MEDI4736 in Adult Subjects With Select Advanced Solid Tumors | NCT02221960

A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors | NCT02335918

Treatment of Advanced Melanoma With MK-3475 and Peginterferon | NCT02112032

Nivolumab and Ipilimumab With or Without Sargramostim in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery | NCT02339571

Durvalumab With or Without Tremelimumab in Advanced Incurable Solid Malignancies Receiving Standard Chemotherapy Regimens | NCT02537418

High-Dose Recombinant Interferon Alfa-2B, Ipilimumab, or Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery | NCT02506153

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