Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.

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Published in Nat Med on September 21, 2015

Authors

Pawel K Mazur1,2, Alexander Herner3, Stephano S Mello2,4, Matthias Wirth3, Simone Hausmann5, Francisco J Sánchez-Rivera6, Shane M Lofgren7,8, Timo Kuschma1,2, Stephan A Hahn9, Deepak Vangala10, Marija Trajkovic-Arsic3, Aayush Gupta3, Irina Heid11, Peter B Noël11, Rickmer Braren11, Mert Erkan5, Jörg Kleeff5, Bence Sipos12, Leanne C Sayles1, Mathias Heikenwalder13,14, Elisabeth Heßmann15, Volker Ellenrieder15, Irene Esposito16, Tyler Jacks6, James E Bradner17, Purvesh Khatri7,8, E Alejandro Sweet-Cordero1, Laura D Attardi2,4, Roland M Schmid3,18, Guenter Schneider3, Julien Sage1,2, Jens T Siveke3,18

Author Affiliations

1: Department of Pediatrics, Stanford University School of Medicine, California, USA.
2: Department of Genetics, Stanford University School of Medicine, California, USA.
3: Second Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
4: Department of Radiation Oncology, Stanford University School of Medicine, California, USA.
5: Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
6: David H. Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
7: Department of Medicine, Stanford University School of Medicine, California, USA.
8: Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, California, USA.
9: Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.
10: Ruhr-University Bochum, Medical Clinic, Knappschaftskrankenhaus, Bochum, Germany.
11: Institute of Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
12: Institute of Pathology, University of Tübingen, Tübingen, Germany.
13: Institute of Virology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
14: Division of Chronic Inflammation and Cancer, German Cancer Research center (DKFZ) Heidelberg, Germany.
15: Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Göttingen, Germany.
16: Institute of Pathology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
17: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
18: German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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