Published in Development on September 23, 2015
Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci (2017) 1.39
A Retroviral CRISPR-Cas9 System for Cellular Autism-Associated Phenotype Discovery in Developing Neurons. Sci Rep (2016) 0.77
Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells. Development (2017) 0.76
Efficient Production of Fluorescent Transgenic Rats using the piggyBac Transposon. Sci Rep (2016) 0.75
Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques. Sci Rep (2016) 0.75
Developing a de novo targeted knock-in method based on in utero electroporation into the mammalian brain. Development (2016) 0.75
Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future. Oncotarget (2016) 0.75
Targeted two-photon chemical apoptotic ablation of defined cell types in vivo. Nat Commun (2017) 0.75
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A (1971) 31.05
DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol (2013) 19.99
Genome engineering using the CRISPR-Cas9 system. Nat Protoc (2013) 15.98
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell (2013) 13.43
Genome-scale CRISPR-Cas9 knockout screening in human cells. Science (2013) 12.36
Genetic screens in human cells using the CRISPR-Cas9 system. Science (2013) 10.75
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell (2013) 9.55
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics (2013) 8.56
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
Cells of origin in cancer. Nature (2011) 6.85
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases. Genome Res (2013) 6.19
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nat Biotechnol (2014) 5.69
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell (2013) 5.40
In vivo genome editing using Staphylococcus aureus Cas9. Nature (2015) 5.26
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat Biotechnol (2014) 5.07
Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res (2008) 3.99
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res (2013) 3.50
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet (2001) 3.48
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet (2001) 3.45
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat Biotechnol (2014) 2.99
Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res (2004) 2.75
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences. Nucleic Acids Res (2014) 2.59
Emerging patterns of somatic mutations in cancer. Nat Rev Genet (2013) 2.50
Heritable gene knockout in Caenorhabditis elegans by direct injection of Cas9-sgRNA ribonucleoproteins. Genetics (2013) 2.44
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells. Nat Methods (2015) 2.29
Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish. Development (2013) 2.22
One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res (2014) 2.20
PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A (2009) 2.07
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors. Nat Biotechnol (2015) 2.03
Microhomology-based choice of Cas9 nuclease target sites. Nat Methods (2014) 1.82
Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes. EMBO J (2009) 1.66
Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circ Res (2014) 1.58
Pten knockdown in vivo increases excitatory drive onto dentate granule cells. J Neurosci (2011) 1.51
New and improved tools for in utero electroporation studies of developing cerebral cortex. Cereb Cortex (2009) 1.44
Efficient isolation of specific genomic regions and identification of associated proteins by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) using CRISPR. Biochem Biophys Res Commun (2013) 1.31
A method for stable transgenesis of radial glia lineage in rat neocortex by piggyBac mediated transposition. J Neurosci Methods (2012) 1.25
ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell (2012) 1.18
Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling. Nat Commun (2015) 1.17
Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci (2014) 1.07
Generation of eGFP and Cre knockin rats by CRISPR/Cas9. FEBS J (2014) 1.06
Efficient, complete deletion of synaptic proteins using CRISPR. Neuron (2014) 1.06
CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons. PLoS One (2014) 1.00
Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells. Brain Pathol (2007) 0.99
Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects. Development (2012) 0.95
Fate mapping by piggyBac transposase reveals that neocortical GLAST+ progenitors generate more astrocytes than Nestin+ progenitors in rat neocortex. Cereb Cortex (2012) 0.90
Alterations of phosphatidylinositol 3-kinase pathway components in epilepsy-associated glioneuronal lesions. Epilepsia (2007) 0.90
Contribution of tumor heterogeneity in a new animal model of CNS tumors. Mol Cancer Res (2014) 0.88
piggyBac transposon-mediated cellular transgenesis in mammalian forebrain by in utero electroporation. Cold Spring Harb Protoc (2014) 0.81