Cells of origin in cancer.

Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell (2011) 4.78

Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev (2012) 3.44

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 3.36

Clonal dynamics of native haematopoiesis. Nature (2014) 3.15

CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08

Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06

Epithelial cell polarity, stem cells and cancer. Nat Rev Cancer (2011) 3.06

Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity. Nat Cell Biol (2013) 2.90

Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature (2013) 2.85

Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell (2012) 2.85

Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell (2012) 2.84

Cancer stem cells: the challenges ahead. Nat Cell Biol (2013) 2.78

Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature (2013) 2.78

Targeted drug delivery to tumors: myths, reality and possibility. J Control Release (2011) 2.69

Substantial contribution of extrinsic risk factors to cancer development. Nature (2015) 2.46

Understanding cancer stem cell heterogeneity and plasticity. Cell Res (2012) 2.39

Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32

From single cells to deep phenotypes in cancer. Nat Biotechnol (2012) 2.12

Cancer stem cells in the development of liver cancer. J Clin Invest (2013) 2.06

Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A (2011) 2.01

Insight into the heterogeneity of breast cancer through next-generation sequencing. J Clin Invest (2011) 1.99

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol (2014) 1.87

Mammary stem cells and the differentiation hierarchy: current status and perspectives. Genes Dev (2014) 1.86

Comparative genomic analysis of primary and synchronous metastatic colorectal cancers. PLoS One (2014) 1.80

Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell (2011) 1.77

The evolving concept of cancer and metastasis stem cells. J Cell Biol (2012) 1.76

Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types. Gastroenterology (2013) 1.76

Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging. Stem Cells (2015) 1.75

Breast cancer - one term, many entities? J Clin Invest (2011) 1.72

Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov (2012) 1.71

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest (2011) 1.65

Mammary gland development. Wiley Interdiscip Rev Dev Biol (2013) 1.64

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML. Leukemia (2012) 1.64

Inferring clonal evolution of tumors from single nucleotide somatic mutations. BMC Bioinformatics (2014) 1.62

A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell (2013) 1.59

Lung adenocarcinoma subtypes based on expression of human airway basal cell genes. Eur Respir J (2013) 1.59

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin. Cancer Cell (2016) 1.55

Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8⁺ T cells. Clin Cancer Res (2011) 1.54

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells. Nature (2015) 1.53

Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression. Cell Tissue Res (2011) 1.53

JNK-induced apoptosis, compensatory growth, and cancer stem cells. Cancer Res (2012) 1.52

Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages. J Anat (2011) 1.51

NF-κB, stem cells and breast cancer: the links get stronger. Breast Cancer Res (2011) 1.51

Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol (2012) 1.50

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes. Cancer Cell (2015) 1.49

Patient-derived xenograft models of breast cancer and their predictive power. Breast Cancer Res (2015) 1.43

LGR5 positivity defines stem-like cells in colorectal cancer. Carcinogenesis (2013) 1.41

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. Proc Natl Acad Sci U S A (2013) 1.37

Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma. Proc Natl Acad Sci U S A (2014) 1.30

Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer. EMBO J (2012) 1.25

Newly identified aspects of tumor suppression by RB. Dis Model Mech (2011) 1.24

Stem cell quiescence acts as a tumour suppressor in squamous tumours. Nat Cell Biol (2013) 1.22

A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell (2013) 1.21

Which are the cells of origin in merkel cell carcinoma? J Skin Cancer (2012) 1.21

Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity. Proc Natl Acad Sci U S A (2012) 1.21

The biology of personalized cancer medicine: facing individual complexities underlying hallmark capabilities. Mol Oncol (2012) 1.21

Evolutionary determinants of cancer. Cancer Discov (2015) 1.19

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nat Cell Biol (2014) 1.19

Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes Dev (2012) 1.17

Dedifferentiation and reprogramming: origins of cancer stem cells. EMBO Rep (2014) 1.16

Frizzled7 as an emerging target for cancer therapy. Cell Signal (2011) 1.16

Tracing epithelial stem cells during development, homeostasis, and repair. J Cell Biol (2012) 1.16

Multiplexed nanoflares: mRNA detection in live cells. Anal Chem (2012) 1.15

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett (2012) 1.14

Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics. Cell Stem Cell (2013) 1.14

Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity. Autophagy (2014) 1.14

Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment. PLoS One (2011) 1.14

Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell (2014) 1.13

Ionizing radiation induces stemness in cancer cells. PLoS One (2012) 1.12

A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors. EMBO J (2012) 1.12

Human cancer growth and therapy in immunodeficient mouse models. Cold Spring Harb Protoc (2014) 1.12

Luminal cells are favored as the cell of origin for prostate cancer. Cell Rep (2014) 1.12

Regulation of hematopoietic and leukemic stem cells by the immune system. Cell Death Differ (2014) 1.10

The origin of breast tumor heterogeneity. Oncogene (2015) 1.09

Modeling sarcomagenesis using multipotent mesenchymal stem cells. Cell Res (2011) 1.09

The aging of the 2000 and 2011 Hallmarks of Cancer reviews: a critique. J Biosci (2013) 1.08

Wnt activation promotes neuronal differentiation of glioblastoma. Cell Death Dis (2013) 1.08

Human solid tumor xenografts in immunodeficient mice are vulnerable to lymphomagenesis associated with Epstein-Barr virus. PLoS One (2012) 1.07

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet (2016) 1.07

Basal cell carcinoma - molecular biology and potential new therapies. J Clin Invest (2012) 1.06

Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene (2011) 1.06

Multifunctional Fe₃O₄@polydopamine core-shell nanocomposites for intracellular mRNA detection and imaging-guided photothermal therapy. ACS Nano (2014) 1.05

Metabostemness: a new cancer hallmark. Front Oncol (2014) 1.05

Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS One (2012) 1.04

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? J Thorac Oncol (2016) 1.03

Elevated PI3K signaling drives multiple breast cancer subtypes. Oncotarget (2011) 1.03

Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Commun (2014) 1.02

Cancer stem-like cells in Epstein-Barr virus-associated nasopharyngeal carcinoma. Chin J Cancer (2014) 1.02

Beyond histology: translating tumor genotypes into clinically effective targeted therapies. Clin Cancer Res (2014) 1.01

Role of SOX family of transcription factors in central nervous system tumors. Am J Cancer Res (2014) 1.01

TGF-β family signaling in stem cells. Biochim Biophys Acta (2012) 1.01

Derailed estrogen signaling and breast cancer: an authentic couple. Endocr Rev (2012) 1.01

Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. Cell Stem Cell (2013) 1.00

CD44+ cancer stem-like cells in EBV-associated nasopharyngeal carcinoma. PLoS One (2012) 0.99

Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact. Expert Rev Proteomics (2011) 0.99

Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proc Natl Acad Sci U S A (2011) 0.99

How does multistep tumorigenesis really proceed? Cancer Discov (2015) 0.98

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells. Proc Natl Acad Sci U S A (2012) 0.98

Cell-of-Origin of Cancer versus Cancer Stem Cells: Assays and Interpretations. Cancer Res (2015) 0.97

Cancer stem cells, a fuzzy evolving concept: a cell population or a cell property? Cell Cycle (2013) 0.97

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63

Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52

Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer (2008) 18.08

Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell (2005) 15.06

Cancer. Addiction to oncogenes--the Achilles heal of cancer. Science (2002) 14.20

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol (2002) 13.87

Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A (2003) 13.00

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature (2006) 11.90

Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med (2004) 11.29

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res (2010) 10.90

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88

Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer (2004) 10.31

Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet (2008) 10.22

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet (2010) 9.72

Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol (2008) 8.70

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25

Tumor stroma and regulation of cancer development. Annu Rev Pathol (2006) 6.66

Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci U S A (2003) 6.35

Identification of a cell of origin for human prostate cancer. Science (2010) 6.33

BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer (2004) 6.24

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell (2004) 5.98

Subtypes of medulloblastoma have distinct developmental origins. Nature (2010) 5.94

Tumor heterogeneity: causes and consequences. Biochim Biophys Acta (2009) 5.90

A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature (2009) 5.65

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature (2008) 5.59

Control of mammary stem cell function by steroid hormone signalling. Nature (2010) 5.38

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet (2000) 5.28

Radial glia cells are candidate stem cells of ependymoma. Cancer Cell (2005) 5.21

Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol (2004) 5.10

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell (2008) 5.06

Mosaic organization of neural stem cells in the adult brain. Science (2007) 5.05

Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell (2009) 4.82

BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci U S A (2008) 4.79

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev (2003) 4.71

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell (2010) 4.66

Gene expression profiles of primary breast tumors maintained in distant metastases. Proc Natl Acad Sci U S A (2003) 4.47

Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell (2008) 4.45

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell (2007) 4.30

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell (2008) 3.79

Lineage dependency and lineage-survival oncogenes in human cancer. Nat Rev Cancer (2006) 3.72

Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature (2010) 3.70

Generation of a prostate from a single adult stem cell. Nature (2008) 3.46

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A (2008) 3.43

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A (2008) 3.40

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science (2008) 3.38

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell (2009) 3.37

The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res (2008) 3.23

Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell (2007) 3.14

Development of a novel mouse glioma model using lentiviral vectors. Nat Med (2009) 3.08

Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin. Cancer Res (2007) 3.05

Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97

Modeling the initiation and progression of human acute leukemia in mice. Science (2007) 2.90

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature (2008) 2.82

Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature (2010) 2.78

Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer (2003) 2.69

Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci U S A (2010) 2.69

The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science (2010) 2.64

Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res (2009) 2.49

Site- and time-specific gene targeting in the mouse. Methods (2001) 2.42

Stem-cell hierarchy in skin cancer. Nat Rev Cancer (2003) 2.36

Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells. Cancer Cell (2008) 2.35

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell (1990) 2.34

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res (2005) 2.19

Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell (2009) 2.14

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene (2009) 1.96

BRCA1 functions as a breast stem cell regulator. J Med Genet (2004) 1.92

Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell (2010) 1.81

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr Biol (1998) 1.69

Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes. EMBO J (2009) 1.66

Mismatch repair deficient colorectal cancer in the era of personalized treatment. Nat Rev Clin Oncol (2010) 1.62

Chronic myelocytic leukemia. Origin of some lymphocytes from leukemic stem cells. J Clin Invest (1978) 1.55

The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54

DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. Cancer Cell (2010) 1.52

A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res (2008) 1.46

Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation. Cancer Cell (2008) 1.46

Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model. PLoS One (2009) 1.24

Drug resistance caused by reversion mutation. Cancer Res (2008) 1.23

Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas. Oncogene (2010) 1.19

Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis. EMBO J (2005) 0.95