Ubiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of Homeostasis.

An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways. PLoS Genet (2017) 0.79

Functional significance of the discordance between transcriptional profile and left ventricular structure/function during reverse remodeling. JCI Insight (2016) 0.78

Immunity, inflammation, and cancer. Cell (2010) 28.27

An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A (1975) 23.42

Apoptosis in the pathogenesis and treatment of disease. Science (1995) 20.24

Origin and physiological roles of inflammation. Nature (2008) 11.68

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (2003) 11.07

Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06

Programmed cell death in animal development. Cell (1997) 8.95

Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85

The ubiquitin code. Annu Rev Biochem (2012) 7.08

TNF-alpha induces two distinct caspase-8 activation pathways. Cell (2008) 6.81

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature (2011) 6.31

Tumour necrosis factor and cancer. Nat Rev Cancer (2009) 6.27

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell (2004) 6.00

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol (2008) 5.90

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell (2009) 5.76

Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell (2002) 5.31

Programmed cell death in animal development and disease. Cell (2011) 5.07

A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J (2006) 4.95

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell (2011) 4.78

Ubiquitin-binding domains - from structures to functions. Nat Rev Mol Cell Biol (2009) 4.62

Ubiquitylation in innate and adaptive immunity. Nature (2009) 4.60

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell (2011) 4.43

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev (1999) 4.39

Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev Cell (2003) 4.23

Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell (2003) 4.07

Basic Medical Research Award. The ubiquitin system. Nat Med (2000) 4.03

Structural basis for the inhibition of caspase-3 by XIAP. Cell (2001) 3.91

The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nat Rev Immunol (2007) 3.88

The emerging complexity of protein ubiquitination. Biochem Soc Trans (2009) 3.85

Structural basis of IAP recognition by Smac/DIABLO. Nature (2001) 3.66

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nat Cell Biol (2003) 3.56

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell (1999) 3.53

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity (2011) 3.53

An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem (2000) 3.44

RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol (2007) 3.43

NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol (2009) 3.39

Role of Drosophila IKK gamma in a toll-independent antibacterial immune response. Nat Immunol (2000) 3.35

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci U S A (2001) 3.19

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature (2011) 3.17

Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J (2002) 3.16

The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity (2011) 3.10

RIP kinases at the crossroads of cell death and survival. Cell (2009) 3.04

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J (2000) 3.02

Necroptosis and its role in inflammation. Nature (2015) 3.01

Structural basis of caspase-7 inhibition by XIAP. Cell (2001) 2.99

Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science (2008) 2.99

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes Dev (2001) 2.96

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity (2009) 2.91

Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer (2006) 2.90

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem (2002) 2.75

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72

A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev (2000) 2.72

p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65

Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol (2004) 2.63

Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Development (2004) 2.54

Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr Biol (2002) 2.54

The Drosophila caspase DRONC is regulated by DIAP1. EMBO J (2000) 2.46

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell (2001) 2.43

Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J Biol Chem (2003) 2.38

Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol (2011) 2.37

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol (2008) 2.32

Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal (2007) 2.30

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module. Mol Cell (2008) 2.27

NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J Biol Chem (2007) 2.13

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol Cell Biol (2004) 2.11

RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell (2011) 2.06

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature (2014) 2.03

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol (2004) 2.03

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol (2009) 2.02

Enhanced protein degradation by branched ubiquitin chains. Cell (2014) 2.02

The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase. Genes Dev (2001) 2.01

The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat Cell Biol (2002) 1.97

Cell competition is a tumour suppressor mechanism in the thymus. Nature (2014) 1.97

A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila. PLoS Biol (2007) 1.96

XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci U S A (2009) 1.95

Cutting edge: the toll pathway is required for resistance to gram-positive bacterial infections in Drosophila. J Immunol (2002) 1.89

Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. Genetics (2000) 1.83

Regulation of the Drosophila apoptosome through feedback inhibition. Nat Cell Biol (2008) 1.83

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. EMBO J (2005) 1.79

Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. Mol Cell (2004) 1.73

Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev Cell (2007) 1.68

Myc-driven endogenous cell competition in the early mammalian embryo. Nature (2013) 1.64

IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol (2004) 1.64

Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev (2008) 1.63

The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling. Cell Host Microbe (2009) 1.63

IAPs limit activation of RIP kinases by TNF receptor 1 during development. EMBO J (2012) 1.61

A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1. Proc Natl Acad Sci U S A (1999) 1.55

Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat Struct Biol (2003) 1.52

Inactivation of effector caspases through nondegradative polyubiquitylation. Mol Cell (2008) 1.51

X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. J Biol Chem (2001) 1.49

Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem/progenitor cells. Gastroenterology (2006) 1.48

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Mol Cell Biol (2004) 1.45

Stress, inflammation, and defense of homeostasis. Mol Cell (2014) 1.44

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP. EMBO J (2001) 1.43

The Drosophila inhibitor of apoptosis D-IAP1 suppresses cell death induced by the caspase drICE. FEBS Lett (1998) 1.39

Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, Dark. EMBO J (2002) 1.38

IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding. EMBO J (2003) 1.38

X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J Biochem (2005) 1.37

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition. Cell Death Differ (2013) 1.36

Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling. Mol Cell (2010) 1.36