Published in J Biol Chem on September 30, 2003
Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol (2005) 8.06
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species. Proc Natl Acad Sci U S A (2005) 2.76
The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb Perspect Biol (2010) 2.64
Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol (2004) 2.47
Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. PLoS Pathog (2006) 2.27
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Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Dev (2004) 1.91
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The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS One (2009) 1.44
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A targeted UAS-RNAi screen in Drosophila larvae identifies wound closure genes regulating distinct cellular processes. Genetics (2010) 1.24
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The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol (2013) 1.21
The RING-finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila. EMBO Rep (2005) 1.20
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TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1. J Immunol (2009) 1.14
The JNK pathway is a key mediator of Anopheles gambiae antiplasmodial immunity. PLoS Pathog (2013) 1.10
Plasmodium falciparum evades mosquito immunity by disrupting JNK-mediated apoptosis of invaded midgut cells. Proc Natl Acad Sci U S A (2014) 1.10
MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Proc Natl Acad Sci U S A (2004) 1.09
Semliki Forest virus strongly reduces mosquito host defence signaling. Insect Mol Biol (2008) 1.09
Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis. J Infect Dis (2012) 1.06
Conventional and non-conventional Drosophila Toll signaling. Dev Comp Immunol (2013) 1.05
The Plasmodium bottleneck: malaria parasite losses in the mosquito vector. Mem Inst Oswaldo Cruz (2014) 1.04
Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling. EMBO J (2012) 1.03
A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. PLoS One (2009) 1.02
Induction of nitric oxide synthase and activation of signaling proteins in Anopheles mosquitoes by the malaria pigment, hemozoin. Infect Immun (2007) 1.01
A quantitative RNAi screen for JNK modifiers identifies Pvr as a novel regulator of Drosophila immune signaling. PLoS Pathog (2009) 1.00
A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response. Mol Cell Biol (2008) 1.00
Quantitative evaluation of signaling events in Drosophila S2 cells. Biol Proced Online (2008) 1.00
Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma. PLoS One (2007) 1.00
Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function. Proc Natl Acad Sci U S A (2012) 1.00
Multiple TGF-β superfamily signals modulate the adult Drosophila immune response. Curr Biol (2011) 0.99
A comprehensive analysis of the Manduca sexta immunotranscriptome. Dev Comp Immunol (2012) 0.99
Mosquito immunity against arboviruses. Viruses (2014) 0.99
Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation. Cold Spring Harb Perspect Biol (2013) 0.98
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Peroxiredoxin 5 modulates immune response in Drosophila. Biochim Biophys Acta (2010) 0.97
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling. Nat Rev Immunol (2012) 0.97
Loss of p24 function in Drosophila melanogaster causes a stress response and increased levels of NF-kappaB-regulated gene products. BMC Genomics (2008) 0.95
Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development. Genetics (2006) 0.92
Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila. Genetics (2014) 0.89
Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi. PLoS Pathog (2014) 0.88
K63-linked ubiquitination in kinase activation and cancer. Front Oncol (2012) 0.87
Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress. Sci Rep (2012) 0.86
Gene expression during zombie ant biting behavior reflects the complexity underlying fungal parasitic behavioral manipulation. BMC Genomics (2015) 0.83
The Drosophila melanogaster host model. J Oral Microbiol (2012) 0.82
Loss of Trabid, a new negative regulator of the drosophila immune-deficiency pathway at the level of TAK1, reduces life span. PLoS Genet (2014) 0.81
An essential role for TAK1 in the contact hypersensitivity response. Cell Mol Immunol (2011) 0.81
Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster. Biosci Rep (2014) 0.81
The protein Dredd is an essential component of the c-Jun N-terminal kinase pathway in the Drosophila immune response. J Biol Chem (2011) 0.80
The characterization of the Phlebotomus papatasi transcriptome. Insect Mol Biol (2013) 0.79
Involvement of neuronal TGF-β activated kinase 1 in the development of tolerance to morphine-induced antinociception in rat spinal cord. Br J Pharmacol (2015) 0.79
Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration. Hum Mol Genet (2014) 0.79
Ubiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of Homeostasis. Curr Top Dev Biol (2015) 0.78
The immune strategy and stress response of the Mediterranean species of the Bemisia tabaci complex to an orally delivered bacterial pathogen. PLoS One (2014) 0.77
POSH misexpression induces caspase-dependent cell death in Drosophila. Dev Dyn (2010) 0.76
Ac-SDKP suppresses TNF-α-induced ICAM-1 expression in endothelial cells via inhibition of IκB kinase and NF-κB activation. Am J Physiol Heart Circ Physiol (2016) 0.76
A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-κB activation and apoptosis in P19 cells. PLoS One (2011) 0.76
Regulation of Antimicrobial Peptides in Aedes aegypti Aag2 Cells. Front Cell Infect Microbiol (2017) 0.75
miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila. PLoS Pathog (2016) 0.75
The morphogen Decapentaplegic employs a two-tier mechanism to activate target retinal determining genes during ectopic eye formation in Drosophila. Sci Rep (2016) 0.75
Dmp53, basket and drICE gene knockdown and polyphenol gallic acid increase life span and locomotor activity in a Drosophila Parkinson's disease model. Genet Mol Biol (2013) 0.75
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell (2007) 7.99
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med (2011) 7.30
Development and mapping of 2240 new SSR markers for rice (Oryza sativa L.). DNA Res (2002) 6.65
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci (2007) 6.08
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature (2012) 5.23
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci U S A (2003) 4.33
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
An atomic model of the interferon-beta enhanceosome. Cell (2007) 4.22
Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature (2012) 3.37
Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection. PLoS Pathog (2012) 3.35
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science (2007) 3.16
A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454. Genome Biol (2010) 2.79
Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing. Mol Cell (2002) 2.78
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev (2005) 2.63
Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. Nature (2012) 2.52
Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proc Natl Acad Sci U S A (2003) 2.42
Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila. Cell (2009) 2.38
Multilevel regulation of gene expression by microRNAs. Science (2008) 2.28
Single-molecule imaging of transcription factor binding to DNA in live mammalian cells. Nat Methods (2013) 2.22
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A (2012) 2.14
Accelerated high-yield generation of limb-innervating motor neurons from human stem cells. J Neurosci (2013) 2.08
The utility of platelet, mean platelet volume, and red cell distribution width in the diagnosis of active Crohn's disease and intestinal tuberculosis. Saudi Med J (2013) 2.01
Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. EMBO J (2004) 2.01
A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep (2013) 1.92
Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. Proc Natl Acad Sci U S A (2005) 1.83
MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes. J Immunol (2009) 1.76
Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. J Biol Chem (2007) 1.72
Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site. Mol Cell (2005) 1.72
MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge. J Immunol (2009) 1.57
CD4⁺T cells: differentiation and functions. Clin Dev Immunol (2012) 1.56
Identification of long-range regulatory elements in the protocadherin-alpha gene cluster. Proc Natl Acad Sci U S A (2006) 1.55
Connecting mitochondria and innate immunity. Cell (2005) 1.54
Video capsule enteroscopy in the diagnosis of celiac disease: a multicenter study. Am J Gastroenterol (2007) 1.53
The plant pathogen Pseudomonas syringae pv. tomato is genetically monomorphic and under strong selection to evade tomato immunity. PLoS Pathog (2011) 1.52
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Rep (2012) 1.50
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A (2013) 1.49
Stochastic expression of the interferon-β gene. PLoS Biol (2012) 1.47
Toric Implantable Collamer Lens for moderate to high myopic astigmatism. Ophthalmology (2007) 1.45
The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS One (2009) 1.44
A graph-theoretic approach to comparing and integrating genetic, physical and sequence-based maps. Genetics (2003) 1.41
Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity. Am J Physiol Lung Cell Mol Physiol (2009) 1.41
CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice. Proc Natl Acad Sci U S A (2012) 1.39
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SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence. Nucleic Acids Res (2010) 1.35
Increased proportions of Bifidobacterium and the Lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease. J Clin Microbiol (2013) 1.34
Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors. Nucleic Acids Res (2014) 1.34
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A (2009) 1.33
Clustered protocadherins. Development (2013) 1.32
The role of ubiquitination in Drosophila innate immunity. J Biol Chem (2005) 1.32
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics (2010) 1.32
Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron (2012) 1.30
Development and mapping of 2240 new SSR markers for rice (Oryza sativa L.) (supplement). DNA Res (2002) 1.29
Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-α gene expression. Proc Natl Acad Sci U S A (2012) 1.26
PPAR{gamma} accelerates cellular senescence by inducing p16INK4{alpha} expression in human diploid fibroblasts. J Cell Sci (2008) 1.25
First prospective, population-based inflammatory bowel disease incidence study in mainland of China: the emergence of "western" disease. Inflamm Bowel Dis (2013) 1.25
IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses. Proc Natl Acad Sci U S A (2011) 1.23
Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China. PLoS One (2008) 1.23
Comparative genomic characterization of Actinobacillus pleuropneumoniae. J Bacteriol (2010) 1.22
Expression of stem cell markers in the human fetal kidney. PLoS One (2009) 1.21
Regulatory elements required for the activation and repression of the protocadherin-alpha gene cluster. Proc Natl Acad Sci U S A (2011) 1.21
A short receptor downregulates JAK/STAT signalling to control the Drosophila cellular immune response. PLoS Biol (2010) 1.20
Arteriovenous malformation after uterine curettage: a report of 3 cases. J Reprod Med (2007) 1.19
Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep (2013) 1.19
Endocytic pathway is required for Drosophila Toll innate immune signaling. Proc Natl Acad Sci U S A (2010) 1.18
Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans. Hum Mol Genet (2012) 1.14
Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol (2006) 1.12
Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury. Am J Respir Crit Care Med (2007) 1.12
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Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret. Proc Natl Acad Sci U S A (2010) 1.08
ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data. Genome Biol (2011) 1.07
miR-221 suppresses ICAM-1 translation and regulates interferon-gamma-induced ICAM-1 expression in human cholangiocytes. Am J Physiol Gastrointest Liver Physiol (2010) 1.06
Computer technology applications in surgical implant dentistry: a systematic review. Int J Oral Maxillofac Implants (2009) 1.05
Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. Br J Haematol (2009) 1.05
Cardiac glycosides are potent inhibitors of interferon-β gene expression. Nat Chem Biol (2010) 1.05
ADMET evaluation in drug discovery. 11. PharmacoKinetics Knowledge Base (PKKB): a comprehensive database of pharmacokinetic and toxic properties for drugs. J Chem Inf Model (2012) 1.04
MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection. J Infect Dis (2010) 1.04
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Toxicity of gold-nanoparticles: synergistic effects of shape and surface functionalization on micromotility of epithelial cells. Nanotoxicology (2010) 1.02
Validity of the Optogait photoelectric system for the assessment of spatiotemporal gait parameters. Med Eng Phys (2012) 1.02
Genomic characterization of Haemophilus parasuis SH0165, a highly virulent strain of serovar 5 prevalent in China. PLoS One (2011) 1.01
Cytotoxicity of metal and semiconductor nanoparticles indicated by cellular micromotility. ACS Nano (2009) 1.01
Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513. J Infect Dis (2010) 1.01
Complete genome sequence of Haemophilus parasuis SH0165. J Bacteriol (2008) 0.98
Intricate interplay between astrocytes and motor neurons in ALS. Proc Natl Acad Sci U S A (2013) 0.97
Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells. Mol Cell Endocrinol (2013) 0.96
Paraovarian cysts of neoplastic origin are underreported. JSLS (2009) 0.96
Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach. BMC Genomics (2009) 0.96
Negative regulation of interferon-β gene expression during acute and persistent virus infections. PLoS One (2011) 0.96
MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection. Int J Parasitol (2011) 0.95
Antimicrobial resistances of extraintestinal pathogenic Escherichia coli isolates from swine in China. Microb Pathog (2011) 0.95
(1)H-NMR-based metabolomics of tumor tissue for the metabolic characterization of rat hepatocellular carcinoma formation and metastasis. Tumour Biol (2010) 0.95
Identification of Streptococcus suis genes preferentially expressed under iron starvation by selective capture of transcribed sequences. FEMS Microbiol Lett (2009) 0.95
Utility of in vitro interferon-γ release assay in differential diagnosis between intestinal tuberculosis and Crohn's disease. J Dig Dis (2013) 0.95
Incorporating naturalistic correlation structure improves spectrogram reconstruction from neuronal activity in the songbird auditory midbrain. J Neurosci (2011) 0.95