Published in Nat Rev Genet on October 07, 2015
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos. Cell (2016) 1.61
Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant. Genes Dev (2016) 0.95
Single-cell genome-wide studies give new insight into nongenetic cell-to-cell variability in animals. Histochem Cell Biol (2016) 0.88
Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation. Genome Res (2016) 0.81
Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq. Nat Genet (2016) 0.80
scphaser: haplotype inference using single-cell RNA-seq data. Bioinformatics (2016) 0.76
Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA (2016) 0.75
SCALE: modeling allele-specific gene expression by single-cell RNA sequencing. Genome Biol (2017) 0.75
Chromosomes in a genome-wise order: evidence for metaphase architecture. Mol Cytogenet (2016) 0.75
Pairing and anti-pairing: a balancing act in the diploid genome. Curr Opin Genet Dev (2016) 0.75
Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE. J Exp Med (2016) 0.75
Para-allopatry in hybridizing fire-bellied toads (Bombina bombina and B. variegata): Inference from transcriptome-wide coalescence analyses. Evolution (2016) 0.75
Mitogen-induced distinct epi-alleles are phosphorylated at either H3S10 or H3S28 depending on H3K27 acetylation. Mol Biol Cell (2017) 0.75
Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets. J Exp Med (2017) 0.75
Assessment of imprinting- and genetic variation-dependent monoallelic expression using reciprocal allele descendants between human family trios. Sci Rep (2017) 0.75
Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. PLoS One (2017) 0.75
Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia. Genome Res (2017) 0.75
Long non-coding RNA SeT and miR-155 regulate the Tnfα gene allelic expression profile. PLoS One (2017) 0.75
Stochastic gene expression in a single cell. Science (2002) 34.54
Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature (1961) 23.98
Global quantification of mammalian gene expression control. Nature (2011) 22.36
Regulation of noise in the expression of a single gene. Nat Genet (2002) 14.93
Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet (2005) 14.39
The hallmarks of aging. Cell (2013) 14.29
Stochastic mRNA synthesis in mammalian cells. PLoS Biol (2006) 12.58
Multiple-laboratory comparison of microarray platforms. Nat Methods (2005) 11.74
Genomic imprinting: parental influence on the genome. Nat Rev Genet (2001) 11.50
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell (2008) 9.76
Stochastic protein expression in individual cells at the single molecule level. Nature (2006) 8.00
Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. Genome Res (2003) 7.86
Widespread monoallelic expression on human autosomes. Science (2007) 7.12
Parental imprinting of the mouse insulin-like growth factor II gene. Cell (1991) 7.11
Interchromosomal interactions and olfactory receptor choice. Cell (2006) 6.93
Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues. J Exp Med (1965) 6.93
Transcriptional pulsing of a developmental gene. Curr Biol (2006) 6.35
Allelic inactivation regulates olfactory receptor gene expression. Cell (1994) 5.93
Variability in gene expression underlies incomplete penetrance. Nature (2010) 5.85
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc Natl Acad Sci U S A (1976) 5.81
Genome-wide detection of single-nucleotide and copy-number variations of a single human cell. Science (2012) 5.50
Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet (2013) 5.48
Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science (2002) 5.47
CEL-Seq: single-cell RNA-Seq by multiplexed linear amplification. Cell Rep (2012) 5.17
Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science (2014) 4.91
The predictive capacity of personal genome sequencing. Sci Transl Med (2012) 4.64
Adaptation to culture of human embryonic stem cells and oncogenesis in vivo. Nat Biotechnol (2007) 4.53
Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data. Nat Rev Genet (2013) 4.38
A gene expression bar code for microarray data. Nat Methods (2007) 4.20
Mammalian genes are transcribed with widely different bursting kinetics. Science (2011) 4.08
Genomic alterations in cultured human embryonic stem cells. Nat Genet (2005) 3.89
Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells. Nat Biotechnol (2011) 3.81
Smart-seq2 for sensitive full-length transcriptome profiling in single cells. Nat Methods (2013) 3.59
Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells. Science (2014) 3.56
Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nat Genet (1998) 3.51
Modeling stochastic gene expression: implications for haploinsufficiency. Proc Natl Acad Sci U S A (1998) 3.49
Quantitative single-cell RNA-seq with unique molecular identifiers. Nat Methods (2013) 3.31
Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model. Genes Dev (2002) 3.14
Genomic imprinting: the emergence of an epigenetic paradigm. Nat Rev Genet (2011) 3.10
Central dogma at the single-molecule level in living cells. Nature (2011) 3.00
Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons. Nat Genet (2005) 2.98
X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell (2013) 2.96
Mice cloned from olfactory sensory neurons. Nature (2004) 2.90
Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes. Nat Immunol (2001) 2.83
Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing. Mol Cell (2002) 2.78
An epigenetic trap stabilizes singular olfactory receptor expression. Cell (2013) 2.63
Mammalian genomic imprinting. Cold Spring Harb Perspect Biol (2011) 2.59
Monoallelic expression of the interleukin-2 locus. Science (1998) 2.58
Prominent roles for odorant receptor coding sequences in allelic exclusion. Cell (2007) 2.58
Regulation of X-chromosome inactivation by the X-inactivation centre. Nat Rev Genet (2011) 2.50
Genome-wide analysis of long noncoding RNA stability. Genome Res (2012) 2.49
Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease. Hum Genet (2013) 2.44
Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos. Nature (1979) 2.36
Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system. Cell (1999) 2.26
Control of ground-state pluripotency by allelic regulation of Nanog. Nature (2012) 2.25
A feedback mechanism regulates monoallelic odorant receptor expression. Proc Natl Acad Sci U S A (2004) 2.24
From single-cell to cell-pool transcriptomes: stochasticity in gene expression and RNA splicing. Genome Res (2013) 2.23
Nuclear aggregation of olfactory receptor genes governs their monogenic expression. Cell (2012) 2.20
Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. Science (1998) 2.13
Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature (2004) 2.09
Allelic gene regulation of Pcdh-alpha and Pcdh-gamma clusters involving both monoallelic and biallelic expression in single Purkinje cells. J Biol Chem (2006) 1.92
Regulation of IL-4 expression by activation of individual alleles. Immunity (1998) 1.84
Single-allele analysis of transcription kinetics in living mammalian cells. Nat Methods (2010) 1.84
Mechanisms and consequences of widespread random monoallelic expression. Nat Rev Genet (2012) 1.81
Large multiallelic copy number variations in humans. Nat Genet (2015) 1.79
Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals. Genome Res (2012) 1.76
An X-linked GFP transgene reveals unexpected paternal X-chromosome activity in trophoblastic giant cells of the mouse placenta. Genesis (2001) 1.73
A single molecule view of gene expression. Trends Cell Biol (2009) 1.69
Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs. Cell Stem Cell (2013) 1.67
Entering the era of single-cell transcriptomics in biology and medicine. Nat Methods (2014) 1.66
Genotype to phenotype: lessons from model organisms for human genetics. Nat Rev Genet (2013) 1.58
Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA. Genome Res (2001) 1.56
Antigen receptor allelic exclusion: an update and reappraisal. J Immunol (2010) 1.54
Independent regulation of the two Pax5 alleles during B-cell development. Nat Genet (1999) 1.54
Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature (2011) 1.52
Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease. Hum Mol Genet (2002) 1.45
Monoallelic expression and asynchronous replication of p120 catenin in mouse and human cells. J Biol Chem (2004) 1.42
Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J Immunol (2000) 1.36
Allele-specific expression patterns of interleukin-2 and Pax-5 revealed by a sensitive single-cell RT-PCR analysis. Curr Biol (2000) 1.31
Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region. Mol Cell Biol (2008) 1.31
Chromatin organization and transcriptional regulation. Curr Opin Genet Dev (2012) 1.31
Probabilistic regulation in TH2 cells accounts for monoallelic expression of IL-4 and IL-13. Immunity (2005) 1.31
Autosomal monoallelic expression in the mouse. Genome Biol (2012) 1.30
Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease. Neuron (2014) 1.24
Biallelic expression of nanog protein in mouse embryonic stem cells. Cell Stem Cell (2013) 1.22
X chromosome inactivation and epigenetic responses to cellular reprogramming. Annu Rev Genomics Hum Genet (2013) 1.21
Random monoallelic gene expression increases upon embryonic stem cell differentiation. Dev Cell (2014) 1.17
Developmental dynamics and disease potential of random monoallelic gene expression. Dev Cell (2014) 1.14
Biased allelic expression in human primary fibroblast single cells. Am J Hum Genet (2014) 1.13
Random monoallelic expression: regulating gene expression one allele at a time. Trends Genet (2014) 1.12
The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever. PLoS Genet (2011) 1.08
Stochastic choice of allelic expression in human neural stem cells. Stem Cells (2012) 1.06
Recent advances in X-chromosome inactivation research. Curr Opin Cell Biol (2012) 1.05
Chromatin signature of widespread monoallelic expression. Elife (2013) 1.03
Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families. PLoS One (2012) 1.00
Expression of the Ly49A gene in murine natural killer cell clones is predominantly but not exclusively mono-allelic. Eur J Immunol (1997) 0.96
Nuclear organization and dosage compensation. Cold Spring Harb Perspect Biol (2010) 0.94
Familial ectrodactyly and polydactyly: variable expressivity of one single gene--embryological considerations. Clin Genet (1982) 0.91
Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1). J Clin Invest (1994) 0.90
Quantifying the transcriptional output of single alleles in single living mammalian cells. Nat Protoc (2013) 0.89