MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity.

PubWeight™: 0.80‹?›

🔗 View Article (PMC 4571540)

Published in FEBS Open Bio on August 31, 2015

Authors

Melissa T Manners1, Yuzhen Tian1, Zhaolan Zhou2, Seena K Ajit1

Author Affiliations

1: Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, USA.
2: Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, USA.

Articles cited by this

MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (2008) 10.11

Cellular and molecular mechanisms of pain. Cell (2009) 9.36

Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain (2000) 6.21

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci (2007) 3.81

Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci (2006) 3.44

Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol (2010) 3.16

The role of MeCP2 in the brain. Annu Rev Cell Dev Biol (2011) 2.84

A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. Hum Mol Genet (2008) 2.13

Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron (2012) 2.11

BDNF as a pain modulator. Prog Neurobiol (2008) 1.73

Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p. Genes Dev (2013) 1.70

Retracted Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem (2009) 1.53

Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. Nat Neurosci (2011) 1.53

The necessity of animal models in pain research. Pain (2010) 1.51

Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice. J Neurosci (2006) 1.41

A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states. J Neurosci (2007) 1.38

BDNF in sensory neurons and chronic pain. Neurosci Res (2006) 1.38

miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int J Cancer (2010) 1.37

Complexities of Rett syndrome and MeCP2. J Neurosci (2011) 1.35

Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2010) 1.33

Experimental models of Rett syndrome based on Mecp2 dysfunction. Exp Biol Med (Maywood) (2011) 1.27

Female Mecp2(+/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies. Hum Mol Genet (2012) 1.23

Linking MECP2 and pain sensitivity: the example of Rett syndrome. Am J Med Genet A (2010) 1.19

Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain. PLoS One (2011) 1.10

Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. J Neuroinflammation (2011) 1.10

The methyl-CpG-binding protein MeCP2 and neurological disease. Biochem Soc Trans (2008) 1.06

Neurotrophins from dorsal root ganglia trigger allodynia after spinal nerve injury in rats. Eur J Neurosci (2000) 1.03

BDNF deregulation in Rett syndrome. Neuropharmacology (2013) 1.02

Trk kinase inhibitors as new treatments for cancer and pain. Expert Opin Ther Pat (2009) 1.02

Linking epigenetics to human disease and Rett syndrome: the emerging novel and challenging concepts in MeCP2 research. Neural Plast (2012) 1.02

Increases in the concentration of brain derived neurotrophic factor in the lumbar spinal dorsal horn are associated with pain behavior following chronic constriction injury in rats. Neurosci Lett (2002) 1.00

The expression of spinal methyl-CpG-binding protein 2, DNA methyltransferases and histone deacetylases is modulated in persistent pain states. Mol Pain (2012) 1.00

A pain research agenda for the 21st century. J Pain (2014) 1.00

MicroRNA-124 as a novel treatment for persistent hyperalgesia. J Neuroinflammation (2012) 0.99

Expression of brain-derived neurotrophic factor in rat dorsal root ganglia, spinal cord and gracile nuclei in experimental models of neuropathic pain. Neuroscience (2001) 0.98

Epigenetic regulation of BDNF expression in the primary sensory neurons after peripheral nerve injury: implications in the development of neuropathic pain. Neuroscience (2013) 0.97

The role of MeCP2 in CNS development and function. Horm Behav (2010) 0.97

Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury. Brain Res (2011) 0.96

Genes and epigenetic processes as prospective pain targets. Genome Med (2013) 0.93

MeCP2 repression of G9a in regulation of pain and morphine reward. J Neurosci (2014) 0.89

Targeting epigenetic mechanisms for pain relief. Curr Opin Pharmacol (2011) 0.86

Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice. Pain (2012) 0.85

The behavioral phenotype in MECP2 duplication syndrome: a comparison with idiopathic autism. Autism Res (2012) 0.83

Potent analgesic effects of a store-operated calcium channel inhibitor. Pain (2013) 0.81

Intrathecal miR-183 delivery suppresses mechanical allodynia in mononeuropathic rats. Eur J Neurosci (2014) 0.80

Effect of histone deacetylase inhibitor JNJ-26481585 in pain. J Mol Neurosci (2014) 0.79