Published in Genome Med on February 15, 2013
Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery | NCT04031716
Transcriptional regulator PRDM12 is essential for human pain perception. Nat Genet (2015) 2.15
Pain vulnerability: a neurobiological perspective. Nat Neurosci (2014) 1.34
Differential methylation of the TRPA1 promoter in pain sensitivity. Nat Commun (2014) 1.19
Neuroplasticity underlying the comorbidity of pain and depression. Neural Plast (2015) 0.86
DNA methylation of RAMP1 gene in migraine: an exploratory analysis. J Headache Pain (2015) 0.81
MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity. FEBS Open Bio (2015) 0.80
Expression levels of the hypothalamic AMPK gene determines the responsiveness of the rats to electroacupuncture-induced analgesia. BMC Complement Altern Med (2014) 0.79
Psychological stress as a modulator of functional recovery following spinal cord injury. Front Neurol (2014) 0.79
Therapeutic Strategies for Neuropathic Pain: Potential Application of Pharmacosynthetics and Optogenetics. Mediators Inflamm (2016) 0.76
Oral manifestations, dental management, and a rare homozygous mutation of the PRDM12 gene in a boy with hereditary sensory and autonomic neuropathy type VIII: a case report and review of the literature. J Med Case Rep (2017) 0.75
DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. Pharmgenomics Pers Med (2017) 0.75
Early-life factors affect risk of pain and fever in infants during teething periods. Clin Oral Investig (2015) 0.75
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Chromatin modifications and their function. Cell (2007) 55.98
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12
The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26
Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain (2005) 13.45
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature (2000) 12.97
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11
The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68
Genomewide association studies and human disease. N Engl J Med (2009) 9.05
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet (1994) 7.04
An SCN9A channelopathy causes congenital inability to experience pain. Nature (2006) 7.01
Rare and common variants: twenty arguments. Nat Rev Genet (2012) 6.67
Persistent pain and well-being: a World Health Organization Study in Primary Care. JAMA (1998) 6.44
Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov (2010) 6.07
Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. Mol Cell (2010) 5.43
Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci (2009) 5.00
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96
COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science (2003) 4.72
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A (1998) 4.67
Chemical phylogenetics of histone deacetylases. Nat Chem Biol (2010) 4.36
Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med (2010) 4.15
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron (2006) 3.96
Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology (2009) 3.64
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45
Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci (2006) 3.44
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38
Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat Genet (1996) 3.35
Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci (2011) 3.27
Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A (2004) 3.07
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain (2006) 2.75
Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature (2011) 2.31
Histone deacetylases as regulators of inflammation and immunity. Trends Immunol (2011) 2.18
Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med (2011) 2.17
Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol (2009) 1.97
Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment. Pain (2009) 1.92
Influences of laboratory environment on behavior. Nat Neurosci (2002) 1.92
Individual differences in pain sensitivity: genetic and environmental contributions. Pain (2007) 1.77
ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol (2008) 1.72
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann Rheum Dis (2012) 1.66
Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker. Pain (2011) 1.63
Genetic predictors for acute experimental cold and heat pain sensitivity in humans. J Med Genet (2006) 1.62
The human mu opioid receptor gene: 5' regulatory and intronic sequences. J Mol Med (Berl) (1998) 1.61
HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner. Learn Mem (2011) 1.59
Heritability of responses to painful stimuli in women: a classical twin study. Brain (2007) 1.59
Adverse events in childhood and chronic widespread pain in adult life: Results from the 1958 British Birth Cohort Study. Pain (2009) 1.58
Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdala. PLoS One (2011) 1.58
Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model. PLoS One (2010) 1.58
Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins. Arthritis Rheum (2004) 1.57
Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study. Ann Rheum Dis (2011) 1.53
The development of new analgesics over the past 50 years: a lack of real breakthrough drugs. Anesth Analg (2010) 1.52
Genetic architecture of human pain perception. Trends Genet (2007) 1.48
Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain. Mol Pharmacol (2009) 1.46
Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement. Neuropsychopharmacology (2009) 1.46
Pain genetics: past, present and future. Trends Genet (2012) 1.44
A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states. J Neurosci (2007) 1.38
Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation. Neuroscience (2009) 1.38
Patterns of pain: meta-analysis of microarray studies of pain. Pain (2011) 1.38
An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. J Neurosci (2012) 1.35
Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease. J Alzheimers Dis (2009) 1.34
Pain as a channelopathy. J Clin Invest (2010) 1.33
Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds. J Neurosci (2010) 1.28
Pain genes. PLoS Genet (2008) 1.23
Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain. Pain (2008) 1.21
Heritability of spinal pain and consequences of spinal pain: a comprehensive genetic epidemiologic analysis using a population-based sample of 15,328 twins ages 20-71 years. Arthritis Rheum (2009) 1.21
Chronic pain: emerging evidence for the involvement of epigenetics. Neuron (2012) 1.21
Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia. Mol Pain (2010) 1.19
Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain. Mol Pain (2007) 1.16
Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans. Mol Pain (2007) 1.16
Differential expression of microRNAs in mouse pain models. Mol Pain (2011) 1.15
Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat Neurosci (2011) 1.13
Two novel SCN9A mutations causing insensitivity to pain. Pain (2009) 1.11
Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain. PLoS One (2011) 1.10
Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. Genes Brain Behav (2010) 1.09
Knockdown of L calcium channel subtypes: differential effects in neuropathic pain. J Neurosci (2010) 1.09
Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain. EMBO J (2011) 1.07
A novel class of small molecule inhibitors of HDAC6. ACS Chem Biol (2011) 1.05
Genes contributing to pain sensitivity in the normal population: an exome sequencing study. PLoS Genet (2012) 1.04
Trk kinase inhibitors as new treatments for cancer and pain. Expert Opin Ther Pat (2009) 1.02
Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain. J Pharmacol Exp Ther (2011) 1.01
The expression of spinal methyl-CpG-binding protein 2, DNA methyltransferases and histone deacetylases is modulated in persistent pain states. Mol Pain (2012) 1.00
MicroRNA changes in the mouse prefrontal cortex after inflammatory pain. Eur J Pain (2011) 0.98
Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. Psychoneuroendocrinology (2012) 0.97
Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury. Brain Res (2011) 0.96
Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain. J Neurosci (2011) 0.94
DNA methylation of SPARC and chronic low back pain. Mol Pain (2011) 0.93
Efficacy of etanercept delivered by perispinal administration for chronic back and/or neck disc-related pain: a study of clinical observations in 143 patients. Curr Med Res Opin (2004) 0.93
A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain. Anesth Analg (2009) 0.92
Re-expression of the methylated EDNRB gene in oral squamous cell carcinoma attenuates cancer-induced pain. Pain (2011) 0.92
Heritability of chronic pain in 2195 extended families. Eur J Pain (2012) 0.90
The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase. Mol Psychiatry (2008) 0.90
Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain. Bioorg Med Chem Lett (2007) 0.90
p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI). Mol Pain (2012) 0.88
Sex-specific variability and a 'cage effect' independently mask a neuropathic pain quantitative trait locus detected in a whole genome scan. Eur J Neurosci (2007) 0.86
Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain. Bioorg Med Chem Lett (2011) 0.86