The role of MeCP2 in the brain.

MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell (2012) 4.56

Interneuron dysfunction in psychiatric disorders. Nat Rev Neurosci (2012) 2.87

Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron (2011) 2.71

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat Neurosci (2013) 2.38

A common mode of recognition for methylated CpG. Trends Biochem Sci (2013) 2.28

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome. Nature (2015) 1.91

Interpreting the language of histone and DNA modifications. Biochim Biophys Acta (2014) 1.80

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Nat Neurosci (2013) 1.74

Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p. Genes Dev (2013) 1.70

A critical and cell-autonomous role for MeCP2 in synaptic scaling up. J Neurosci (2012) 1.69

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. Immunity (2015) 1.61

Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses. Sci Transl Med (2012) 1.56

Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Proc Natl Acad Sci U S A (2013) 1.52

Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome. Proc Natl Acad Sci U S A (2014) 1.51

From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci (2015) 1.44

Nuclear calcium signalling in the regulation of brain function. Nat Rev Neurosci (2013) 1.44

An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev (2012) 1.38

Mobile DNA elements in the generation of diversity and complexity in the brain. Nat Rev Neurosci (2014) 1.35

Methylomic trajectories across human fetal brain development. Genome Res (2015) 1.35

Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome. J Neurosci (2013) 1.26

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders. Neuron (2015) 1.24

The impact of MeCP2 loss- or gain-of-function on synaptic plasticity. Neuropsychopharmacology (2012) 1.22

Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron (2012) 1.18

Rett syndrome: genes, synapses, circuits, and therapeutics. Front Psychiatry (2012) 1.14

Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures. J Neurosci (2014) 1.11

What obesity research tells us about epigenetic mechanisms. Philos Trans R Soc Lond B Biol Sci (2013) 1.11

Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Transl Psychiatry (2014) 1.10

Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2. Proc Natl Acad Sci U S A (2015) 1.05

"Seq-ing" insights into the epigenetics of neuronal gene regulation. Neuron (2013) 1.03

Dynamic Roles of microRNAs in Neurogenesis. Front Neurosci (2012) 1.01

Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression. Philos Trans R Soc Lond B Biol Sci (2012) 1.00

Effects of DNA methylation on nucleosome stability. Nucleic Acids Res (2013) 0.99

MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis? Front Cell Neurosci (2014) 0.99

miR-132 enhances HIV-1 replication. Virology (2013) 0.98

DNA methylation and childhood maltreatment: from animal models to human studies. Neuroscience (2013) 0.98

Clinical and biological progress over 50 years in Rett syndrome. Nat Rev Neurol (2016) 0.95

Epigenetic Risk Factors in PTSD and Depression. Front Psychiatry (2013) 0.95

Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. PLoS Genet (2014) 0.95

Running-induced epigenetic and gene expression changes in the adolescent brain. Int J Dev Neurosci (2012) 0.94

SIRT1 in the brain-connections with aging-associated disorders and lifespan. Front Cell Neurosci (2015) 0.93

SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression. Epigenetics (2012) 0.92

Non-CG Methylation in the Human Genome. Annu Rev Genomics Hum Genet (2015) 0.92

Genetic and pharmacological reactivation of the mammalian inactive X chromosome. Proc Natl Acad Sci U S A (2014) 0.91

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. Neurobiol Dis (2014) 0.91

Molecular pathway reconstruction and analysis of disturbed gene expression in depressed individuals who died by suicide. PLoS One (2012) 0.91

Regulation of brain-derived neurotrophic factor expression in neurons. Int J Physiol Pathophysiol Pharmacol (2012) 0.91

Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil. Genes Nutr (2012) 0.91

The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity. Mol Cancer Res (2012) 0.90

Astrocytes conspire with neurons during progression of neurological disease. Curr Opin Neurobiol (2012) 0.90

Epigenetics, autism spectrum, and neurodevelopmental disorders. Neurotherapeutics (2013) 0.89

Assessment of epigenetic contributions to sexually-dimorphic Kiss1 expression in the anteroventral periventricular nucleus of mice. Endocrinology (2012) 0.89

MeCP2 repression of G9a in regulation of pain and morphine reward. J Neurosci (2014) 0.89

Investigating mechanisms underlying neurodevelopmental phenotypes of autistic and intellectual disability disorders: a perspective. Front Syst Neurosci (2013) 0.89

Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action. J Neurosci (2012) 0.89

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders. Curr Mol Med (2015) 0.89

GABA and glutamate pathways are spatially and developmentally affected in the brain of Mecp2-deficient mice. PLoS One (2014) 0.88

MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity. J Neurosci (2014) 0.88

Induced pluripotent stem cells to model and treat neurogenetic disorders. Neural Plast (2012) 0.88

MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5. Sci Signal (2014) 0.88

Fetal hypoxia increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of glucocorticoid receptors. Neurobiol Dis (2014) 0.88

Mapping pathological phenotypes in a mouse model of CDKL5 disorder. PLoS One (2014) 0.88

MicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological Diseases. Int J Mol Sci (2016) 0.87

MeCP2 as a genome-wide modulator: the renewal of an old story. Front Genet (2012) 0.87

Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes. Epigenetics (2012) 0.87

Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder. Oxid Med Cell Longev (2013) 0.86

Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS One (2013) 0.86

Mendelian disorders of the epigenetic machinery: tipping the balance of chromatin states. Annu Rev Genomics Hum Genet (2014) 0.86

Respiratory phenotypes are distinctly affected in mice with common Rett syndrome mutations MeCP2 T158A and R168X. Neuroscience (2014) 0.86

DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution. Epigenetics Chromatin (2014) 0.86

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife (2016) 0.86

Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome. Transl Psychiatry (2013) 0.85

Translational research: Rett syndrome and tuberous sclerosis complex. Curr Opin Pediatr (2011) 0.85

MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation. Proc Natl Acad Sci U S A (2014) 0.85

DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å. Biochemistry (2013) 0.84

Xq28 (MECP2) microdeletions are common in mutation-negative females with Rett syndrome and cause mild subtypes of the disease. Mol Cytogenet (2013) 0.84

Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes. Front Cell Neurosci (2015) 0.84

Persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced MeCP2 repression of GluA1 in rat central amygdala. J Neurosci (2015) 0.84

Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome. Neuropsychopharmacology (2014) 0.84

Nuclear calcium signaling controls methyl-CpG-binding protein 2 (MeCP2) phosphorylation on serine 421 following synaptic activity. J Biol Chem (2012) 0.84

Epigenetic Regulation of Infant Neurobehavioral Outcomes. Med Epigenet (2014) 0.83

Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping. Nucleic Acids Res (2014) 0.83

Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain. Nucleic Acids Res (2013) 0.83

Developmental Dynamics of Rett Syndrome. Neural Plast (2016) 0.82

Elevated IKKα accelerates the differentiation of human neuronal progenitor cells and induces MeCP2-dependent BDNF expression. PLoS One (2012) 0.82

Inflammatory lung disease in Rett syndrome. Mediators Inflamm (2014) 0.82

Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex. Epigenetics (2015) 0.82

MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Nat Commun (2016) 0.82

DNA methylation in the gene body influences MeCP2-mediated gene repression. Proc Natl Acad Sci U S A (2016) 0.82

MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line. PLoS One (2012) 0.82

Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure. Circ Res (2015) 0.82

Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias. Sci Rep (2015) 0.82

Biomechanical properties of bone in a mouse model of Rett syndrome. Bone (2014) 0.81

Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice. Autism Open Access (2012) 0.81

MeCP2 regulates ethanol sensitivity and intake. Addict Biol (2013) 0.81

Cytosine modifications in neurodevelopment and diseases. Cell Mol Life Sci (2013) 0.81

Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders. Mol Brain (2014) 0.81

Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons. Stem Cells (2015) 0.81

Genotype-specific effects of Mecp2 loss-of-function on morphology of Layer V pyramidal neurons in heterozygous female Rett syndrome model mice. Front Cell Neurosci (2015) 0.81

Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia. PLoS One (2016) 0.81

Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs. Oxid Med Cell Longev (2015) 0.81

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57

DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet (2008) 15.45

CpG islands and the regulation of transcription. Genes Dev (2011) 9.50

A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol (2008) 7.95

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res (2004) 7.50

Reversal of neurological defects in a mouse model of Rett syndrome. Science (2007) 7.09

CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature (2010) 4.86

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature (2011) 3.28

BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73

Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Res (2011) 2.51

CpG methylation is targeted to transcription units in an invertebrate genome. Genome Res (2007) 2.47

A temporal threshold for formaldehyde crosslinking and fixation. PLoS One (2009) 2.03

Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet (2005) 1.87

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci U S A (2007) 1.84

The major form of MeCP2 has a novel N-terminus generated by alternative splicing. Nucleic Acids Res (2004) 1.79

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Nat Neurosci (2013) 1.74

Kaiso-deficient mice show resistance to intestinal cancer. Mol Cell Biol (2006) 1.67

53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin. J Cell Sci (2005) 1.62

DNA methylation and Rett syndrome. Hum Mol Genet (2003) 1.62

Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil. PLoS Biol (2009) 1.61

Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Genes Dev (2012) 1.55

Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol Cell Biol (2006) 1.52

Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet (2003) 1.44

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A (2003) 1.29

Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome. J Neurosci (2013) 1.26

Mbd2 contributes to DNA methylation-directed repression of the Xist gene. Mol Cell Biol (2007) 1.22

MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene (2003) 1.21

Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells. PLoS One (2010) 1.17

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome. Brain (2012) 1.14

Genomic approaches reveal unexpected genetic divergence within Ciona intestinalis. J Mol Evol (2005) 1.14

The effect of interspecific oocytes on demethylation of sperm DNA. Proc Natl Acad Sci U S A (2004) 1.14

Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows. Hum Mol Genet (2012) 1.10

Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons. Stem Cells (2012) 1.09

DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse. Development (2003) 1.09

Molecular biology. MeCP2 repression goes nonglobal. Science (2003) 1.07

Reversibility of functional deficits in experimental models of Rett syndrome. Biochem Soc Trans (2010) 1.03

MMDiff: quantitative testing for shape changes in ChIP-Seq data sets. BMC Genomics (2013) 1.02

Paradoxical role of an Egr transcription factor family member, Egr2/Krox20, in learning and memory. Front Behav Neurosci (2007) 1.01

Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. Nat Genet (2006) 1.00

Distinct functions of egr gene family members in cognitive processes. Front Neurosci (2008) 1.00

MeCP2 and other methyl-CpG binding proteins. Ment Retard Dev Disabil Res Rev (2002) 0.94

Il2 transcription unleashed by active DNA demethylation. Nat Immunol (2003) 0.93

Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. Am J Pathol (2004) 0.92

Putting the DNA back into DNA methylation. Nat Genet (2011) 0.92

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS One (2007) 0.91

MBD2 is required for correct spatial gene expression in the gut. Mol Cell Biol (2007) 0.89

MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene (2004) 0.89

Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells. Genome Biol (2014) 0.87

MBD2-mediated transcriptional repression of the p14ARF tumor suppressor gene in human colon cancer cells. Pathobiology (2008) 0.86

MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene (2005) 0.82

Identical sets of methylated and nonmethylated genes in Ciona intestinalis sperm and muscle cells. Epigenetics Chromatin (2013) 0.81

A unique DNA methylation signature defines a population of IFN-γ/IL-4 double-positive T cells during helminth infection. Eur J Immunol (2014) 0.80

Large-scale study of phosphoproteins involved in long-term potentiation in the rat dentate gyrus in vivo. Eur J Neurosci (2008) 0.75