The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26456319)

Published in J Cell Biochem on October 20, 2015

Authors

Stefano Zanotti1, Ernesto Canalis1

Author Affiliations

1: Departments of Orthopaedic Surgery and Medicine, and The UConn Musculoskeletal Institute, UConn Health, Farmington, 06030, Connecticut.

Articles cited by this

Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods (2009) 22.47

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell (1997) 15.96

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci U S A (1988) 10.90

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature (1998) 10.58

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res (2010) 9.95

Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (1998) 8.02

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res (1985) 7.67

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet (2006) 7.53

Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A (2003) 6.55

RANK is essential for osteoclast and lymph node development. Genes Dev (1999) 5.85

Matrix-embedded cells control osteoclast formation. Nat Med (2011) 5.77

Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med (2011) 5.66

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab (2007) 4.64

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell (2006) 4.28

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A (2000) 3.95

Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell (2006) 3.42

Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res (2007) 3.38

DMP1-targeted Cre expression in odontoblasts and osteocytes. J Dent Res (2007) 3.07

Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Mol Cell Biol (2010) 2.85

Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A (2005) 2.41

Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. Bone (2004) 2.35

HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Dev Biol (1999) 2.27

Update on Wnt signaling in bone cell biology and bone disease. Gene (2011) 2.03

Effect of primary and secondary structure of oligodeoxyribonucleotides on the fluorescent properties of conjugated dyes. Nucleic Acids Res (2002) 1.98

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. Bone (2011) 1.96

Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res (1996) 1.86

HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol (2001) 1.85

PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling. J Bone Miner Res (2011) 1.72

Multiplex quantitative PCR using self-quenched primers labeled with a single fluorophore. Nucleic Acids Res (2002) 1.72

Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin. Mol Cell Biol (2011) 1.70

Notch and the skeleton. Mol Cell Biol (2009) 1.49

More complicated than it looks: assembly of Notch pathway transcription complexes. Oncogene (2008) 1.48

Mechanotransduction and functional response of the skeleton to physical stress: the mechanisms and mechanics of bone adaptation. J Orthop Sci (1998) 1.45

Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone. Bone (2010) 1.33

Osteoblast lineage-specific effects of notch activation in the skeleton. Endocrinology (2012) 1.32

β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice. J Bone Miner Res (2013) 1.25

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin. J Cell Biol (2013) 1.24

Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches. Nat Rev Endocrinol (2013) 1.23

Notch signaling in skeletal health and disease. Eur J Endocrinol (2013) 1.00

Reciprocal regulation of Notch and nuclear factor of activated T-cells (NFAT) c1 transactivation in osteoblasts. J Biol Chem (2010) 0.99

One year of transgenic overexpression of osteoprotegerin in rats suppressed bone resorption and increased vertebral bone volume, density, and strength. J Bone Miner Res (2009) 0.99

Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling. J Biol Chem (2013) 0.98

Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling-induced osteoprotegerin expression. Genes Cells (2008) 0.96

Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture. Bone (2014) 0.89

Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats. Bone (2014) 0.86

Isolation of mouse osteocytes using cell fractionation for gene expression analysis. Methods Mol Biol (2012) 0.85