Published in Dev Biol on December 01, 1999
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2003) 4.89
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev (2004) 4.41
Notch signaling is essential for ventricular chamber development. Dev Cell (2007) 2.53
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development (2002) 2.31
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A (2000) 2.05
Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A (2002) 2.04
Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem (2007) 1.99
HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol (2001) 1.85
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood (2008) 1.83
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol (2001) 1.77
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (2006) 1.67
Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes. Mol Cell Biol (2004) 1.55
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest (2010) 1.54
Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics (2000) 1.49
The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem (2000) 1.47
Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A (2007) 1.42
Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol (2009) 1.32
Osteoblast lineage-specific effects of notch activation in the skeleton. Endocrinology (2012) 1.32
The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm. Genes Dev (2000) 1.22
The pathogenic role of Notch activation in podocytes. Nephron Exp Nephrol (2009) 1.17
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers. Development (2011) 1.16
Notch-1 signalling is activated in brain arteriovenous malformations in humans. Brain (2009) 1.15
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev (2005) 1.13
The Notch effector Hey1 associates with myogenic target genes to repress myogenesis. J Biol Chem (2009) 1.11
Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am J Physiol Heart Circ Physiol (2006) 1.10
Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis. PLoS One (2011) 1.09
Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development. BMC Dev Biol (2008) 1.07
Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes. Stem Cell Res (2013) 1.05
Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell (2013) 1.01
Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. Dev Biol (2007) 1.01
Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol (2008) 0.99
Notch signaling in cardiac development and disease. Pediatr Cardiol (2009) 0.98
Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling. J Biol Chem (2013) 0.98
Transcriptional regulation during development of the ductus arteriosus. Circ Res (2008) 0.96
HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program. J Cell Biol (2001) 0.96
Characterization of hey bHLH genes in teleost fish. Dev Genes Evol (2003) 0.95
Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway. Stem Cells (2014) 0.92
The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload. Am J Physiol Heart Circ Physiol (2010) 0.91
bHLH-Orange Transcription Factors in Development and Cancer. Transl Oncogenomics (2007) 0.89
CHF1/Hey2 promotes physiological hypertrophy in response to pressure overload through selective repression and activation of specific transcriptional pathways. OMICS (2009) 0.88
Transcription factor CHF1/Hey2 regulates coronary vascular maturation. Mech Dev (2010) 0.87
Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. PLoS One (2010) 0.87
Hey bHLH factors in cardiovascular development. Pediatr Cardiol (2009) 0.87
Expression of HES and HEY genes in infantile hemangiomas. Vasc Cell (2011) 0.86
Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. J Cell Biol (2007) 0.85
HeyL promotes neuronal differentiation of neural progenitor cells. J Neurosci Res (2011) 0.84
Interleukin 6 mediates selected effects of Notch in chondrocytes. Osteoarthritis Cartilage (2013) 0.84
Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. Am J Physiol Heart Circ Physiol (2012) 0.84
Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proc Natl Acad Sci U S A (2007) 0.84
Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption. J Biol Chem (2015) 0.83
High efficiency differentiation of human pluripotent stem cells to cardiomyocytes and characterization by flow cytometry. J Vis Exp (2014) 0.82
Comparative analysis of somitogenesis related genes of the hairy/Enhancer of split class in Fugu and zebrafish. BMC Genomics (2002) 0.81
Soluble forms of the Notch ligands Delta1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distinct phenotypes. Am J Pathol (2008) 0.81
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One (2014) 0.80
Transcription Factor CHF1/Hey2 Regulates Specific Pathways in Serum Stimulated Primary Cardiac Myocytes: Implications for Cardiac Hypertrophy. Curr Genomics (2010) 0.79
Cardiac cell lineages that form the heart. Cold Spring Harb Perspect Med (2014) 0.78
Choose your destiny: Make a cell fate decision with COUP-TFII. J Steroid Biochem Mol Biol (2015) 0.78
Cardiac differentiation of human pluripotent stem cells. J Cell Mol Med (2012) 0.78
HeyL regulates the number of TrkC neurons in dorsal root ganglia. Dev Biol (2009) 0.77
Canonical Notch activation in osteocytes causes osteopetrosis. Am J Physiol Endocrinol Metab (2015) 0.77
The bHLH transcription factor, hairy, refines the terminal cell fate in the Drosophila embryonic trachea. PLoS One (2010) 0.76
An Antibody to Notch2 Reverses the Osteopenic Phenotype of Hajdu-Cheney Mutant Male Mice. Endocrinology (2017) 0.76
Duplication of HEY2 in cardiac and neurologic development. Am J Med Genet A (2015) 0.75
Genetic and epigenetic mechanisms in the development of arteriovenous malformations in the brain. Clin Epigenetics (2016) 0.75
The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele. J Cell Biochem (2015) 0.75
Hairy and Enhancer of Split-related with YRPW Motif-Like (HeyL) is Dispensable for Bone Remodeling in Mice. J Cell Biochem (2016) 0.75
Sustained Notch2 Signaling in Osteoblasts, but no in Osteoclasts, is Linked to Osteopenia in a Mouse Model of Hajdu-Cheney Syndrome. J Biol Chem (2017) 0.75
Parathyroid hormone inhibits notch signaling in osteoblasts and osteocytes. Bone (2017) 0.75
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