Published in eNeuro on July 10, 2015
Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins. J Neurosci (2015) 0.85
Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks. Cell Rep (2016) 0.84
Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration. Mol Neurobiol (2016) 0.77
Psychiatric disorders biochemical pathways unraveled by human brain proteomics. Eur Arch Psychiatry Clin Neurosci (2016) 0.75
REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation. Front Cell Neurosci (2015) 0.75
Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels. FEBS Lett (2017) 0.75
Genome-wide mapping of in vivo protein-DNA interactions. Science (2007) 64.92
An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73
REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell (2005) 8.65
The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science (1995) 6.85
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J (2001) 6.85
Nova regulates brain-specific splicing to shape the synapse. Nat Genet (2005) 6.58
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43
Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci U S A (2006) 5.78
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet (2003) 4.76
REST and stress resistance in ageing and Alzheimer's disease. Nature (2014) 4.38
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature (2009) 3.66
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci U S A (2004) 3.39
2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure. Nat Neurosci (2006) 3.36
The many faces of REST oversee epigenetic programming of neuronal genes. Curr Opin Neurobiol (2005) 3.25
Comparative genomics modeling of the NRSF/REST repressor network: from single conserved sites to genome-wide repertoire. Genome Res (2006) 3.23
Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet (2007) 3.18
A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol (2002) 3.09
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature (2008) 2.84
Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch (2010) 2.83
Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Nat Neurosci (1999) 2.77
Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol (2006) 2.49
A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J Neurosci (2007) 2.45
Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J Neurosci (1998) 2.42
REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol (2008) 2.12
Ischemic insults derepress the gene silencer REST in neurons destined to die. J Neurosci (2003) 2.08
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell (2008) 1.94
The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. J Neurosci (2011) 1.87
Evolutionary conservation of long non-coding RNAs; sequence, structure, function. Biochim Biophys Acta (2013) 1.79
Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. J Neurosci (2007) 1.77
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease. J Neurosci (2007) 1.77
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat Neurosci (2011) 1.57
Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med (2013) 1.54
Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting. Genome Res (2012) 1.54
Distinct profiles of REST interactions with its target genes at different stages of neuronal development. Mol Biol Cell (2005) 1.52
The potential of HDAC inhibitors as cognitive enhancers. Annu Rev Pharmacol Toxicol (2013) 1.52
Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes. Neuron (2014) 1.51
Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat Cell Biol (2011) 1.49
Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death. Proc Natl Acad Sci U S A (2012) 1.48
DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet (2008) 1.45
MicroRNAs: regulators of neuronal fate. Curr Opin Cell Biol (2013) 1.43
microRNAs in neurons: manifold regulatory roles at the synapse. Curr Opin Genet Dev (2011) 1.42
Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo. Proc Natl Acad Sci U S A (2000) 1.38
Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol (2011) 1.37
The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci (2013) 1.36
Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nat Rev Neurosci (2013) 1.35
REST and CoREST modulate neuronal subtype specification, maturation and maintenance. PLoS One (2009) 1.34
Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons. Proc Natl Acad Sci U S A (2007) 1.34
The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. Neurobiol Dis (2010) 1.32
Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism. J Biol Chem (1996) 1.31
Autophagy in Huntington disease and huntingtin in autophagy. Trends Neurosci (2014) 1.28
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci (2014) 1.27
Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases. Brain Res Bull (2013) 1.26
REST-mediated recruitment of polycomb repressor complexes in mammalian cells. PLoS Genet (2012) 1.26
The dynorphin/κ-opioid receptor system and its role in psychiatric disorders. Cell Mol Life Sci (2011) 1.25
REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development (2009) 1.25
DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome. Hum Mol Genet (2009) 1.19
Regulation of neural macroRNAs by the transcriptional repressor REST. RNA (2008) 1.18
REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors. Nat Neurosci (2012) 1.17
The transcription factor REST is lost in aggressive breast cancer. PLoS Genet (2010) 1.17
Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis. Mol Cell (2011) 1.15
Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene. J Biol Chem (2004) 1.13
Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β. J Mol Neurosci (2011) 1.12
Crosstalk among Epigenetic Pathways Regulates Neurogenesis. Front Neurosci (2012) 1.10
The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord. Biochem Biophys Res Commun (2003) 1.09
SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution. Hum Mol Genet (2010) 1.07
REST and the RESTless: in stem cells and beyond. Future Neurol (2009) 1.06
Cardiac T-type Ca(2+) channels in the heart. J Mol Cell Cardiol (2009) 1.05
Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis. Development (2012) 1.04
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife (2013) 1.03
Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease. Biochem Soc Trans (2009) 1.01
Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride. J Neurosci (2009) 1.01
Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models. Neurobiol Dis (2006) 1.01
Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury. Neuroscience (2009) 0.98
REST: an oncogene or a tumor suppressor? Trends Cell Biol (2013) 0.98
The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes. Elife (2014) 0.96
Neuron-restrictive silencer factor regulates the N-methyl-D-aspartate receptor 2B subunit gene in basal and ethanol-induced gene expression in fetal cortical neurons. Mol Pharmacol (2005) 0.96
Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model. Cereb Cortex (2011) 0.95
Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells. J Biol Chem (2014) 0.95
Epigenetics and epilepsy. Epilepsia (2012) 0.95
Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(β-TRCP) in neuroblastoma cells. Cancer (2011) 0.93
Histone deacetylases in memory and cognition. Sci Signal (2014) 0.92
Chromatin remodeling in neural stem cell differentiation. Curr Opin Neurobiol (2010) 0.91
LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy. Cereb Cortex (2014) 0.91
MicroRNA targeting of CoREST controls polarization of migrating cortical neurons. Cell Rep (2014) 0.91
Kainate exposure suppresses activation of GluR2 subunit promoter in primary cultured cerebral cortical neurons through induction of RE1-silencing transcription factor. Neurosci Lett (2006) 0.90
High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. Stem Cells (2013) 0.90
Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory. Neurobiol Learn Mem (2011) 0.88
REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability. EMBO J (2013) 0.88
Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death. J Neurosci (2014) 0.88
REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes. J Cell Biol (2011) 0.88
Transcriptional activation of REST by Sp1 in Huntington's disease models. PLoS One (2010) 0.87
NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP. Neurobiol Aging (2012) 0.87
Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet. Epilepsia (2011) 0.87
Ethanol-induced neurodegeneration in NRSF/REST neuronal conditional knockout mice. Neuroscience (2011) 0.87
Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription. Nucleic Acids Res (2004) 0.87
The NRSE smRNA specifies the fate of adult hippocampal neural stem cells. Nucleic Acids Symp Ser (Oxf) (2005) 0.87
Characterization of the nuclear targeting signal of REST/NRSF. Neurosci Lett (2006) 0.87
Actions of sodium valproate on the central nervous system. J Physiol Pharmacol (1999) 0.87