Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.

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Published in EMBO J on December 17, 2001

Authors

M Göttlicher1, S Minucci, P Zhu, O H Krämer, A Schimpf, S Giavara, J P Sleeman, F Lo Coco, C Nervi, P G Pelicci, T Heinzel

Author Affiliations

1: Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, H.-v.-Helmholtz-Platz 1, D-76344 Eggenstein, Germany. martin.goettlicher@itg.fzk.de

Associated clinical trials:

Trial of Oral Valproic Acid for Retinitis Pigmentosa (VPA) | NCT01233609

Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid (GAMA) | NCT02608736

Evaluating Dietary Intervention Before surgicaL Treatment for Epilepsy (EDIBLE) | NCT02261753

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