Published in Cell on May 20, 2005
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data. Nat Methods (2008) 11.61
Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res (2008) 8.89
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron (2006) 6.50
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev (2007) 5.83
Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci U S A (2006) 5.78
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol Cell (2007) 5.67
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci (2009) 5.27
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev (2007) 5.16
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell (2009) 4.60
Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell (2007) 4.45
REST and stress resistance in ageing and Alzheimer's disease. Nature (2014) 4.38
Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res (2007) 4.13
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature (2009) 3.66
The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. J Neurosci (2008) 3.62
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell (2008) 3.53
Comparative genomics modeling of the NRSF/REST repressor network: from single conserved sites to genome-wide repertoire. Genome Res (2006) 3.23
Mechanisms, regulation and consequences of protein SUMOylation. Biochem J (2010) 3.22
Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One (2010) 3.14
REST maintains self-renewal and pluripotency of embryonic stem cells. Nature (2008) 3.06
Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet (2011) 2.99
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature (2008) 2.84
Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol (2006) 2.49
Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol (2006) 2.48
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature (2008) 2.46
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron (2007) 2.38
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A (2009) 2.30
Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.16
DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma (2009) 2.13
REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol (2008) 2.12
Isolation of neuronal chromatin from brain tissue. BMC Neurosci (2008) 2.02
Regulation and function of miRNA-21 in health and disease. RNA Biol (2011) 1.99
The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. J Neurosci (2011) 1.87
Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol (2006) 1.83
Epigenetic mechanisms in mammals. Cell Mol Life Sci (2009) 1.82
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Mol Cell (2009) 1.81
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) (2010) 1.76
Neural stem cell self-renewal. Crit Rev Oncol Hematol (2007) 1.76
Eloquent silence: developmental functions of Class I histone deacetylases. Curr Opin Genet Dev (2008) 1.74
Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways. Nat Neurosci (2010) 1.68
The Yin and Yang of YY1 in the nervous system. J Neurochem (2008) 1.68
The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging (Albany NY) (2011) 1.65
Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication. Nucleic Acids Res (2006) 1.62
Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol (2010) 1.60
ATP-dependent chromatin remodeling in neural development. Curr Opin Neurobiol (2009) 1.58
REST controls self-renewal and tumorigenic competence of human glioblastoma cells. PLoS One (2012) 1.58
Distinct profiles of REST interactions with its target genes at different stages of neuronal development. Mol Biol Cell (2005) 1.52
Oct4 targets regulatory nodes to modulate stem cell function. PLoS One (2007) 1.52
Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat Cell Biol (2011) 1.49
Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death. Proc Natl Acad Sci U S A (2012) 1.48
Cancer stem cells in glioblastoma--molecular signaling and therapeutic targeting. Protein Cell (2010) 1.45
DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet (2008) 1.45
Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery. Genome Biol (2016) 1.43
Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation. PLoS One (2015) 1.39
Stable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue. Mol Biol Cell (2006) 1.36
Epigenetic regulation of oligodendrocyte identity. Trends Neurosci (2010) 1.36
Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nat Rev Neurosci (2013) 1.35
Complexities of Rett syndrome and MeCP2. J Neurosci (2011) 1.35
REST and CoREST modulate neuronal subtype specification, maturation and maintenance. PLoS One (2009) 1.34
Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons. Proc Natl Acad Sci U S A (2007) 1.34
Histone regulation in the CNS: basic principles of epigenetic plasticity. Neuropsychopharmacology (2012) 1.33
Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21. EMBO Mol Med (2013) 1.30
Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Res (2009) 1.30
Epigenetic mechanisms for nutrition determinants of later health outcomes. Am J Clin Nutr (2009) 1.28
Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2. Genes Dev (2012) 1.28
Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiol Dis (2010) 1.26
REST-mediated recruitment of polycomb repressor complexes in mammalian cells. PLoS Genet (2012) 1.26
The molecular basis of organ formation: insights from the C. elegans foregut. Annu Rev Cell Dev Biol (2009) 1.26
Neurogenesis in the embryonic and adult brain: same regulators, different roles. Front Cell Neurosci (2014) 1.25
REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development (2009) 1.25
REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions. Cell Cycle (2010) 1.24
The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. J Neurosci (2007) 1.22
The multiple layers of ubiquitin-dependent cell cycle control. Chem Rev (2009) 1.22
Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene. FASEB J (2009) 1.21
REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements. Mol Cell Biol (2011) 1.21
Regulatory elements required for the activation and repression of the protocadherin-alpha gene cluster. Proc Natl Acad Sci U S A (2011) 1.21
Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation. PLoS One (2009) 1.20
Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus. Proc Natl Acad Sci U S A (2010) 1.19
Regulation of neural macroRNAs by the transcriptional repressor REST. RNA (2008) 1.18
Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron (2012) 1.18
REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors. Nat Neurosci (2012) 1.17
The transcription factor REST is lost in aggressive breast cancer. PLoS Genet (2010) 1.17
Regulation of non-coding RNA networks in the nervous system--what's the REST of the story? Neurosci Lett (2009) 1.16
Profiling RE1/REST-mediated histone modifications in the human genome. Genome Biol (2009) 1.16
B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo. PLoS Genet (2010) 1.15
p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol (2008) 1.15
Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells. Curr Biol (2008) 1.14
C2H2 zinc finger-SET histone methyltransferase is a plant-specific chromatin modifier. Dev Biol (2006) 1.14
REST regulates DYRK1A transcription in a negative feedback loop. J Biol Chem (2011) 1.14
No rest for REST: REST/NRSF regulation of neurogenesis. Cell (2005) 1.14
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. J Biol Chem (2008) 1.13
Epigenetic mechanisms regulating fate specification of neural stem cells. Philos Trans R Soc Lond B Biol Sci (2008) 1.13
Targeting Huntington's disease through histone deacetylases. Clin Epigenetics (2011) 1.13
Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions. Proc Natl Acad Sci U S A (2010) 1.12
Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease. Front Genet (2014) 1.11
Crosstalk among Epigenetic Pathways Regulates Neurogenesis. Front Neurosci (2012) 1.10
BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. J Biol Chem (2006) 1.10
Large-scale expression analysis reveals distinct microRNA profiles at different stages of human neurodevelopment. PLoS One (2010) 1.10
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08
Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci U S A (2006) 5.78
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16
Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science (2002) 4.19
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci (2007) 3.81
Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology. Nat Neurosci (2009) 3.42
The many faces of REST oversee epigenetic programming of neuronal genes. Curr Opin Neurobiol (2005) 3.25
A role for glia in the progression of Rett's syndrome. Nature (2011) 3.18
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78
Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. Proc Natl Acad Sci U S A (2005) 2.67
A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J Neurosci (2007) 2.45
microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc Natl Acad Sci U S A (2010) 2.28
Imaging neuronal activity during zebrafish behavior with a genetically encoded calcium indicator. J Neurophysiol (2003) 2.16
Suprachiasmatic nucleus organization. Cell Tissue Res (2002) 2.13
Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science (2008) 1.83
REST repression of neuronal genes requires components of the hSWI.SNF complex. J Biol Chem (2002) 1.73
Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. J Comp Neurol (2004) 1.58
Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron. J Neurosci (2004) 1.58
Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A (2013) 1.50
Epigenetic mechanisms and gene networks in the nervous system. J Neurosci (2005) 1.33
Cowchock syndrome is associated with a mutation in apoptosis-inducing factor. Am J Hum Genet (2012) 1.30
Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junction. Proc Natl Acad Sci U S A (2010) 1.28
Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome. J Neurosci (2013) 1.26
MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain. J Neurosci (2012) 1.25
Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish. J Neurosci (2004) 1.24
A clustering property of highly-degenerate transcription factor binding sites in the mammalian genome. Nucleic Acids Res (2006) 1.21
A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation. J Neurosci (2004) 1.19
C2H2 zinc finger-SET histone methyltransferase is a plant-specific chromatin modifier. Dev Biol (2006) 1.14
The first 30 minutes in the life of a virus: unREST in the nucleus. Cell Cycle (2005) 1.12
Translocation of CaM kinase II to synaptic sites in vivo. Nat Neurosci (2003) 1.08
The Zebrafish motility mutant twitch once reveals new roles for rapsyn in synaptic function. J Neurosci (2002) 1.07
Repressor element 1 silencing transcription factor (REST) controls radial migration and temporal neuronal specification during neocortical development. Proc Natl Acad Sci U S A (2011) 1.04
Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology. J Neurosci (2013) 0.94
Zebrafish calls for reinterpretation for the roles of P/Q calcium channels in neuromuscular transmission. J Neurosci (2013) 0.92
Astrocytes conspire with neurons during progression of neurological disease. Curr Opin Neurobiol (2012) 0.90
A mutation in serca underlies motility dysfunction in accordion zebrafish. Dev Biol (2004) 0.90
Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked. J Neurophysiol (2004) 0.87
Synaptic homeostasis in a zebrafish glial glycine transporter mutant. J Neurophysiol (2008) 0.86
An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses. J Gen Physiol (2011) 0.86
Serotonin innervation of the primate suprachiasmatic nucleus. Brain Res (2004) 0.84
Synchronous and asynchronous modes of synaptic transmission utilize different calcium sources. Elife (2013) 0.84
Genetics of low spinal muscular atrophy carrier frequency in sub-Saharan Africa. Ann Neurol (2014) 0.82
Acetylcholine receptor gating in a zebrafish model for slow-channel syndrome. J Neurosci (2012) 0.81
Zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery. Proc Natl Acad Sci U S A (2012) 0.80
Tracking tagged molecules in single neurons in intact zebrafish. CSH Protoc (2007) 0.75