Published in Fibrogenesis Tissue Repair on October 15, 2015
Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res (1999) 12.83
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis (2010) 4.24
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med (2012) 3.96
Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology (2012) 3.34
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest (2011) 2.83
Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature (2015) 2.77
ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity. Liver Int (2015) 2.75
Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A (2010) 2.66
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun (2012) 2.65
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A (2012) 2.54
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology (2005) 2.41
Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol (2014) 2.29
Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology (2011) 2.27
Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver. Development (2009) 2.26
Hippo pathway activity influences liver cell fate. Cell (2014) 2.24
Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells. Hepatology (2010) 2.23
Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis. Hepatology (2015) 2.20
Origin and structural evolution of the early proliferating oval cells in rat liver. Am J Pathol (2001) 2.07
Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse. Hepatology (2002) 2.06
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol (2010) 1.91
Smoothened is a master regulator of adult liver repair. J Clin Invest (2013) 1.89
A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. J Exp Med (2015) 1.87
A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver. Hepatology (2001) 1.80
Ductular reactions in human liver: diversity at the interface. Hepatology (2011) 1.70
Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice. J Exp Med (2000) 1.68
WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. J Clin Invest (2015) 1.68
Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology (2007) 1.66
Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol (2011) 1.62
Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease. Fibrogenesis Tissue Repair (2011) 1.61
The fractalkine receptor CX₃CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology (2010) 1.59
Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology (2008) 1.56
Generation of mice with a conditional null allele for Wntless. Genesis (2010) 1.55
Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology (2013) 1.53
Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology (2004) 1.51
Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol (2015) 1.45
Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Gut (2010) 1.44
Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. Gut (2009) 1.44
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology (2013) 1.40
Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice. Hepatology (2012) 1.33
Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury. Am J Pathol (2009) 1.28
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis (2012) 1.25
The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease. Hepatology (2014) 1.24
Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proc Natl Acad Sci U S A (2013) 1.20
Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence. Am J Pathol (2009) 1.18
Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol (2005) 1.17
Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation. Hepatology (2007) 1.15
Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury. J Hepatol (2007) 1.12
Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun (2007) 1.09
β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation! Hepatology (2014) 1.09
Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation. Biochim Biophys Acta (2012) 1.07
Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response. Gut (2010) 1.05
Macrophages: central regulators of hepatic fibrogenesis and fibrosis resolution. J Hepatol (2012) 1.04
Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury. Am J Pathol (2011) 1.01
EpCAM and the biology of hepatic stem/progenitor cells. Am J Physiol Gastrointest Liver Physiol (2014) 0.99
Depletion of β-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development. Proc Natl Acad Sci U S A (2011) 0.99
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis. Am J Physiol Gastrointest Liver Physiol (2015) 0.97
Matrix metalloproteinase-13 promotes recovery from experimental liver cirrhosis in rats. Pathobiology (2011) 0.97
Disparate cellular basis of improved liver repair in beta-catenin-overexpressing mice after long-term exposure to 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Am J Pathol (2010) 0.96
Role and regulation of β-catenin signaling during physiological liver growth. Gene Expr (2014) 0.95
Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response. FEBS Lett (2009) 0.94
Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways. Biochim Biophys Acta (2012) 0.92
The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiation. Am J Pathol (2010) 0.86
Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C. Liver Int (2012) 0.86
Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis. J Leukoc Biol (2014) 0.86
Adeno-associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice. Hepatol Int (2007) 0.83
Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse. PLoS One (2014) 0.81
Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a. FASEB J (2015) 0.80
Standard operating procedures in experimental liver research: thioacetamide model in mice and rats. Lab Anim (2015) 0.77