Immunological landscape and immunotherapy of hepatocellular carcinoma.

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Published in Nat Rev Gastroenterol Hepatol on October 20, 2015

Authors

Jesús Prieto1, Ignacio Melero2, Bruno Sangro3

Author Affiliations

1: Department of Medicine, Clinica Universidad de Navarra and Centre for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII, 31080 Pamplona, Spain.
2: Department of Oncology, Clinica Universidad de Navarra and Centre for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII, 31080 Pamplona, Spain.
3: Liver Unit, Clinica Universidad de Navarra and Centre for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII, 31080 Pamplona, Spain. CIBERehd, Instituto de Salud Carlos III, Monforte de Lemos 3-5, Avenida Pio XII, 28029 Madrid, Spain.

Associated clinical trials:

Safety Study of Anti-LAG-3 With and Without Anti-PD-1 in the Treatment of Solid Tumors | NCT01968109

Efficacy and Safety Study of Talimogene Laherparepvec Compared to Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) in Melanoma | NCT00769704

Trial of TRX518 (Anti-GITR mAb) in Stage III or IV Malignant Melanoma or Other Solid Tumors (TRX518-001) | NCT01239134

Study of the Safety and Tolerability of Urelumab Administered in Combination With Nivolumab in Solid Tumors and B-cell Non-Hodgkins Lymphoma | NCT02253992

Safety, Tolerability, Pharmacokinetics, and Immunoregulatory Study of Urelumab (BMS-663513) in Subjects With Advanced and/or Metastatic Solid Tumors and Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma | NCT01471210

Stereotactic Body Radiation and Monoclonal Antibody to OX40 (MEDI6469) in Breast Cancer Patients With Metastatic Lesions (OX40 Breast) | NCT01862900

A Phase 2b Study of Modified Vaccinia Virus to Treat Patients Advanced Liver Cancer Who Failed Sorafenib (TRAVERSE) | NCT01387555

A Study of RO5137382 (GC33) in Patients With Advanced or Metastatic Hepatocellular Carcinoma | NCT01507168

Efficacy Study of Recombinant Adenovirus for Non Muscle Invasive Bladder Cancer (BOND) | NCT01438112

A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1 | NCT00948961

Safety Study of Adenovirus Vector Engineered to Express hIL-12 in Combination With Activator Ligand to Treat Melanoma | NCT01397708

Phase I/IIa AdCD40L Immunogene Therapy for Malignant Melanoma and Other Solid Tumors | NCT01455259

Vector Delivery of the IL-12 Gene in Men With Prostate Cancer | NCT00406939

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