Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.

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🔗 View Article (PMID 25428504)

Published in Nature on November 27, 2014

Authors

Roy S Herbst1, Jean-Charles Soria2, Marcin Kowanetz3, Gregg D Fine3, Omid Hamid4, Michael S Gordon5, Jeffery A Sosman6, David F McDermott7, John D Powderly8, Scott N Gettinger1, Holbrook E K Kohrt9, Leora Horn10, Donald P Lawrence11, Sandra Rost3, Maya Leabman3, Yuanyuan Xiao3, Ahmad Mokatrin3, Hartmut Koeppen3, Priti S Hegde3, Ira Mellman3, Daniel S Chen3, F Stephen Hodi12

Author Affiliations

1: Yale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA.
2: Gustave Roussy South-Paris University, 114 Rue Edouard Vaillant, 94805 Villefuij, Cedex, France.
3: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
4: The Angeles Clinic and Research Institute, 11818 Wilshire Blvd, Los Angeles, California 90025, USA.
5: Pinnacle Oncology Hematology, 9055 E Del Camino Dr 100, Scottsdale, Arizona 85258, USA.
6: Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue, Nashville, Tennessee 37212, USA.
7: Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 9, Boston, Massachusetts 02215, USA.
8: Carolina BioOncology Institute, 9801 W. Kincey Ave, Suite 145, Huntersville, North Carolina 28078, USA.
9: Stanford University, CCSR Bldg Room 1110, Stanford, California 94305, USA.
10: Vanderbilt-Ingram Cancer Center, 1301 Medical Center Dr, Suite 1710, Nashville, Tennessee 37212, USA.
11: Massachusetts General Hospital, 55 Fruit Street, YAW 9E, Boston, Massachusetts 02114, USA.
12: Dana-Farber/Brigham and Women's Cancer Center, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.

Associated clinical trials:

A Phase 1 Study of Atezolizumab (an Engineered Anti-PDL1 Antibody) in Patients With Locally Advanced or Metastatic Solid Tumors | NCT01375842

Immunotherapy Using Precision T Cells Specific to Personalized Neo-antigen for the Treatment of Advanced Malignant Tumor of Biliary Tract | NCT02632019

Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated Metastatic Colorectal Cancer QUILT-2.004 | NCT03050814

CAR-T Cell Immunotherapy for Advanced Lung Cancer | NCT03330834

Phase II Trial of Neoadjuvant and Adjuvant Anti-PD-1 Antibody Toripalimab Combined With CCRT in NPC Patients | NCT03925090

Toripalimab Combined With Gemcitabine/5--fluoropyrimidine for Advanced Cholangiocarcinoma | NCT03982680

CyPep-1 Injections in Cancer Inducing Lymphocyte Infiltrate Accumulations (CICILIA) | NCT04260529

Chemotherapy and Immunotherapy as Treatment for MSS Metastatic Colorectal Cancer With High Immune Infiltrate (POCHI) | NCT04262687

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