Published in J Biol Chem on April 15, 1989
Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion. J Cell Biol (1991) 2.88
Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes. Proc Natl Acad Sci U S A (1990) 2.83
Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. J Cell Biol (1990) 2.50
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol (1997) 2.46
Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo. J Clin Invest (1992) 2.38
Extracellular matrix molecules and their receptors: functions in neural development. Annu Rev Neurosci (1991) 2.27
Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations. J Cell Biol (1991) 2.27
Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. J Cell Biol (1990) 2.24
Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J (1990) 2.23
The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin. J Cell Biol (1990) 2.18
Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells. EMBO J (1990) 2.16
The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J Cell Biol (1997) 2.03
Cloning, primary structure and properties of a novel human integrin beta subunit. EMBO J (1990) 2.03
The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol (1989) 2.02
Regulation of the VLA integrin-ligand interactions through the beta 1 subunit. J Cell Biol (1992) 1.96
Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules. J Cell Biol (1990) 1.85
The integrin alpha 6 beta 4 is a laminin receptor. J Cell Biol (1992) 1.77
A function for the integrin alpha 6 beta 4 in the hemidesmosome. Cell Regul (1991) 1.76
Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination. J Cell Biol (1993) 1.74
The alpha 1-alpha 6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron. J Cell Biol (1990) 1.64
Why integrin as a primary target for imaging and therapy. Theranostics (2011) 1.61
A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components. J Cell Biol (1992) 1.57
Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of alpha 6 beta 4 and alpha 2 beta 1 integrins. Cell Regul (1990) 1.55
Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen. J Cell Biol (1990) 1.54
Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis. Mol Cell Biol (2006) 1.51
Surface relocation of alpha 6 beta 4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing. J Cell Biol (1991) 1.47
p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. J Cell Biol (1999) 1.46
Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. J Cell Biol (1991) 1.42
Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation. J Cell Biol (1991) 1.36
Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules. Am J Pathol (1991) 1.34
Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit. J Cell Biol (1993) 1.34
Proteolytic processing of endogenous and recombinant beta 4 integrin subunit. J Cell Biol (1992) 1.34
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit. J Cell Biol (1993) 1.32
Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. J Cell Sci (2009) 1.25
Changes in expression of alpha 6/beta 4 integrin heterodimer in primary and metastatic breast cancer. Br J Cancer (1992) 1.24
Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases. Am J Pathol (1991) 1.22
Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v. J Cell Biol (1990) 1.22
The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice. Am J Pathol (1997) 1.17
Cell surface molecules and their prognostic values in assessing colorectal carcinomas. Ann Surg (2000) 1.08
Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit. Proc Natl Acad Sci U S A (1990) 1.07
Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation. Neoplasia (2008) 1.07
A novel integrin involved in thymocyte-thymic epithelial cell interactions. J Exp Med (1991) 1.04
Upregulation and redistribution of integrin alpha6beta4 expression occurs at an early stage in pancreatic adenocarcinoma progression. Mod Pathol (2007) 1.03
Integrin alpha6Bbeta4 inhibits colon cancer cell proliferation and c-Myc activity. BMC Cancer (2009) 1.03
Integrins in lens development and disease. Exp Eye Res (2008) 1.00
Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells. Clin Exp Metastasis (2003) 0.99
Expression of the VLA beta 1 integrin family in bladder cancer. Am J Pathol (1994) 0.96
Evidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM. J Cell Biol (1999) 0.96
Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 integrin subunit in normal and hyperplastic synovial lining cell layer. Am J Pathol (1993) 0.94
Vitronectin receptor: tissue specific expression or adaptation to culture? Int J Exp Pathol (1990) 0.93
Ocular cicatricial pemphigoid antigen: partial sequence and biochemical characterization. Proc Natl Acad Sci U S A (1996) 0.92
Integrin β4 regulates SPARC protein to promote invasion. J Biol Chem (2012) 0.91
Triggering through CD16 or phorbol esters enhances adhesion of NK cells to laminin via very late antigen 6. J Exp Med (1992) 0.89
Distribution of integrin cell adhesion molecules in endometrial cancer. Am J Pathol (1995) 0.88
A novel beta 4, alpha 6 integrin-associated epithelial cell antigen involved in natural killer cell and antigen-specific cytotoxic T lymphocyte cytotoxicity. J Exp Med (1991) 0.86
Effects of β4 integrin expression on microRNA patterns in breast cancer. Biol Open (2012) 0.85
Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction. Clin Exp Metastasis (1997) 0.84
Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis. Mol Carcinog (2010) 0.81
Effects of 1 alpha,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsoriatic drugs. Arch Dermatol Res (1993) 0.78
Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress. Sci Rep (2015) 0.77
Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development. Dev Biol (2015) 0.76
\4 integrin expression onin vitro andin vivo metastatic variants of lewis lung carcinoma. Cytotechnology (1991) 0.75
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell (1990) 8.87
Long-term nonsurgical management of Barrett's esophagus with high-grade dysplasia. Gastroenterology (2001) 5.80
Protection by endoscopy against death from colorectal cancer. A case-control study among veterans. Arch Intern Med (1995) 5.59
Colorectal cancer prevention 2000: screening recommendations of the American College of Gastroenterology. American College of Gastroenterology. Am J Gastroenterol (2000) 4.17
Function and interactions of integrins. Cell Tissue Res (2001) 4.13
Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med (1985) 3.73
Prevention of colorectal cancer by flexible endoscopy and polypectomy. A case-control study of 32,702 veterans. Ann Intern Med (1995) 3.54
Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. Nat Genet (1996) 3.52
Helicobacter-negative gastritis: a distinct entity unrelated to Helicobacter pylori infection. Aliment Pharmacol Ther (2014) 3.38
The prevalence of hemorrhoids and chronic constipation. An epidemiologic study. Gastroenterology (1990) 3.22
The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin. J Cell Biol (1990) 3.07
A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody. J Biol Chem (1987) 2.94
Structural and functional aspects of filamins. Biochim Biophys Acta (2001) 2.89
Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit. J Biol Chem (1989) 2.71
Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol (1999) 2.64
Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol (1995) 2.41
Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor. Cell (1995) 2.32
Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J (1990) 2.23
Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J Biol Chem (1988) 2.20
AGA technical review: evaluation of dyspepsia. American Gastroenterological Association. Gastroenterology (1998) 2.19
Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors. Int J Cancer (1984) 2.12
Pancreatitis is a risk factor for pancreatic cancer. Gastroenterology (1995) 2.11
Temporal changes in the occurrence of hemorrhoids in the United States and England. Dis Colon Rectum (1991) 2.09
The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function. EMBO J (1989) 2.03
The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. J Cell Biol (2000) 2.00
Gastric surgery is not a risk for Barrett's esophagus or esophageal adenocarcinoma. Gastroenterology (2001) 1.99
Opposing time trends of peptic ulcer and reflux disease. Gut (1998) 1.99
Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem (1989) 1.88
Clinical epidemiology of chronic constipation. J Clin Gastroenterol (1989) 1.85
Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules. J Cell Biol (1990) 1.85
Predictors of duodenal ulcer healing and relapse. Gastroenterology (1981) 1.78
Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity. EMBO J (1987) 1.69
The alpha 6 beta 4 integrin is a receptor for both laminin and kalinin. Exp Cell Res (1994) 1.69
Epidemiology and practice patterns of achalasia in a large multi-centre database. Aliment Pharmacol Ther (2011) 1.67
Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology (1997) 1.66
Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol (1999) 1.64
Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J Cell Biol (1999) 1.64
Development of mouse mammary gland: identification of stages in differentiation of luminal and myoepithelial cells using monoclonal antibodies and polyvalent antiserum against keratin. J Histochem Cytochem (1986) 1.61
Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180. J Cell Biol (1998) 1.58
Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: recognition of laminin isoforms. Mol Biol Cell (1994) 1.56
Hemidesmosomes: roles in adhesion, signaling and human diseases. Curr Opin Cell Biol (1996) 1.56
Efficient management of diarrhea in the acquired immunodeficiency syndrome (AIDS). A medical decision analysis. Ann Intern Med (1990) 1.55
Biology and function of hemidesmosomes. Matrix Biol (1999) 1.51
Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins. J Cell Sci (2000) 1.46
Geographic and temporal variations in the occurrence of peptic ulcer disease. Scand J Gastroenterol Suppl (1985) 1.45
Ethnic variations in the occurrence of gastroesophageal cancers. J Clin Gastroenterol (1999) 1.43
Military history of patients with inflammatory bowel disease: an epidemiological study among U.S. veterans. Am J Gastroenterol (1998) 1.42
Limitations of the faecal occult blood test in screening for colorectal cancer. Ital J Gastroenterol Hepatol (1999) 1.42
P-selectin mediates Ca(2+)-dependent adhesion of activated platelets to many different types of leukocytes: detection by flow cytometry. Blood (1992) 1.41
Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes. Mol Biol Cell (2003) 1.41
Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits. Dev Biol (2001) 1.38
Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes. Eur J Biochem (1991) 1.38
Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties. J Cell Sci (1996) 1.37
Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit. J Cell Biol (1993) 1.34
The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. J Biol Chem (2000) 1.27
Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin. J Biol Chem (1991) 1.26
Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1. FEBS Lett (1990) 1.26
Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer. Gut (1983) 1.25
Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. J Biol Chem (1992) 1.24
Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events. Bioessays (1999) 1.24
alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development. J Cell Sci (2000) 1.23
Corpus gastritis is protective against reflux oesophagitis. Gut (1999) 1.23
Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development. J Cell Biol (1998) 1.23
Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer. Am J Gastroenterol (2001) 1.23
Antibody to integrin alpha 6 subunit specifically inhibits cell-binding to laminin fragment 8. Exp Cell Res (1990) 1.21
Associations between different forms of gastro-oesophageal reflux disease. Gut (1997) 1.21
Expression and function of the cytoplasmic variants of the integrin alpha 6 subunit in transfected K562 cells. Activation-dependent adhesion and interaction with isoforms of laminin. J Biol Chem (1993) 1.20
When is esophagitis healed? esophageal endoscopy, histology and function before and after cimetidine treatment. Dig Dis Sci (1982) 1.20
Step-down management of gastroesophageal reflux disease. Gastroenterology (2001) 1.20
The impact of colorectal cancer screening on life expectancy. Gastrointest Endosc (2000) 1.18
Reflux symptoms are associated with psychiatric disease. Aliment Pharmacol Ther (2001) 1.17
Risk factors of colorectal cancer in inflammatory bowel disease. Am J Gastroenterol (1996) 1.17
A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells. J Cell Sci (1997) 1.17
Salivary secretion in reflux esophagitis. Gastroenterology (1982) 1.17
180-kD bullous pemphigoid antigen (BP180) is deficient in generalized atrophic benign epidermolysis bullosa. J Clin Invest (1995) 1.16
Is there a link between cervical inlet patch and Barrett's esophagus? Gastrointest Endosc (2001) 1.15
Demonstration of type II hemidesmosomes in a mammary gland epithelial cell line, BMGE-H. J Biochem (1994) 1.14
Relation between gastric cancer and previous peptic ulcer disease. Gut (1997) 1.14
Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression. J Cell Biol (2000) 1.14
Sonographic measurements of the normal liver, spleen, pancreas, and portal vein. Radiology (1983) 1.13
Screening for high-grade dysplasia in gastroesophageal reflux disease: is it cost-effective? Am J Gastroenterol (2000) 1.11
Occurrence of a cohort phenomenon in peptic ulcer mortality from Switzerland. Gastroenterology (1984) 1.11
Causative factors in the etiology of peptic ulcer disease become effective before the age of 15 years. J Chronic Dis (1987) 1.11
Geographic variation in the incidence of and mortality from inflammatory bowel disease. Dis Colon Rectum (1986) 1.10
Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells. Mol Biol Cell (1997) 1.09
Birth-cohort analysis of peptic ulcer mortality in Europe. J Chronic Dis (1985) 1.09
The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit. J Cell Biol (1997) 1.07
The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor. J Biol Chem (1993) 1.07
Disability pensions due to peptic ulcer in Germany between 1953 and 1983. Am J Epidemiol (1985) 1.07
Outcome of erosive reflux esophagitis after Nissen fundoplication. Am J Gastroenterol (1999) 1.06
Two different mutations in the cytoplasmic domain of the integrin beta 4 subunit in nonlethal forms of epidermolysis bullosa prevent interaction of beta 4 with plectin. J Invest Dermatol (2001) 1.06
Dietary salt and gastric ulcer. Gut (1986) 1.06
A novel beta 1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle. FEBS Lett (1995) 1.04
Occupational factors in disability pensions for gastric and duodenal ulcer. J Occup Med (1986) 1.03
Changes in physician visits for gastric and duodenal ulcer in the United States during 1958-1984 as shown by National Disease and Therapeutic Index (NDTI). Dig Dis Sci (1987) 1.02
Comparison of different strategies for treatment of duodenal ulcer. Br Med J (Clin Res Ed) (1985) 1.01
Characteristics of intestinal metaplasia in the gastric cardia. Am J Gastroenterol (1999) 1.01