Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180.

PubWeight™: 1.58‹?› | Rank: Top 4%

🔗 View Article (PMC 2133016)

Published in J Cell Biol on July 13, 1998

Authors

R Q Schaapveld1, L Borradori, D Geerts, M R van Leusden, I Kuikman, M G Nievers, C M Niessen, R D Steenbergen, P J Snijders, A Sonnenberg

Author Affiliations

1: Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

Articles citing this

Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin. J Cell Biol (2005) 3.17

EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol (2001) 2.46

The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. J Cell Biol (2000) 2.00

Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J Cell Biol (1999) 1.64

An epidermal plakin that integrates actin and microtubule networks at cellular junctions. J Cell Biol (2000) 1.60

Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis. Mol Cell Biol (2006) 1.51

In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa. Proc Natl Acad Sci U S A (2001) 1.48

Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol (2005) 1.44

E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles. EMBO J (2003) 1.44

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes. Mol Biol Cell (2003) 1.41

Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol Cell Biol (2004) 1.31

Dynamics of the alpha6beta4 integrin in keratinocytes. Mol Biol Cell (2002) 1.29

Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol Biol Cell (2007) 1.22

Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes. EMBO J (2009) 1.14

The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome. Mol Biol Cell (2000) 1.14

Different phenotypes in human prostate cancer: alpha6 or alpha3 integrin in cell-extracellular adhesion sites. Neoplasia (2002) 1.13

EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4. J Biol Chem (2010) 1.12

Epidermolysis bullosa with pyloric atresia. Dermatol Clin (2010) 1.12

Specificity of binding of the plectin actin-binding domain to beta4 integrin. Mol Biol Cell (2003) 1.09

Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation. J Biol Chem (2010) 1.01

Involvement of alpha6beta4 integrin in the mechanisms that regulate breast cancer progression. Breast Cancer Res (2007) 0.96

Epidermolysis bullosa simplex associated with pyloric atresia is a novel clinical subtype caused by mutations in the plectin gene (PLEC1). J Mol Diagn (2005) 0.93

Type XVII collagen regulates lamellipod stability, cell motility, and signaling to Rac1 by targeting bullous pemphigoid antigen 1e to alpha6beta4 integrin. J Biol Chem (2011) 0.93

Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly. Mol Biol Cell (2012) 0.93

Integrin α6β4 in colorectal cancer. World J Gastrointest Pathophysiol (2010) 0.93

Advances and perspectives of the architecture of hemidesmosomes: lessons from structural biology. Cell Adh Migr (2009) 0.92

A compound heterozygous one amino-acid insertion/nonsense mutation in the plectin gene causes epidermolysis bullosa simplex with plectin deficiency. Am J Pathol (2001) 0.91

Caspase proteolysis of the integrin beta4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration. J Biol Chem (2006) 0.91

Collagen XVII and BPAG1 expression in the retina: evidence for an anchoring complex in the central nervous system. J Comp Neurol (2005) 0.89

Adhesion and migration, the diverse functions of the laminin alpha3 subunit. Dermatol Clin (2010) 0.88

Communication between the cell membrane and the nucleus: role of protein compartmentalization. J Cell Biochem Suppl (1998) 0.86

Type XVII collagen (BP180) can function as a cell-matrix adhesion molecule via binding to laminin 332. Matrix Biol (2010) 0.83

Molecular architecture and function of the hemidesmosome. Cell Tissue Res (2014) 0.83

Kindlin-1 regulates integrin dynamics and adhesion turnover. PLoS One (2013) 0.82

Dynamic interactions of epidermal collagen XVII with the extracellular matrix: laminin 332 as a major binding partner. Am J Pathol (2011) 0.80

miR-221/222 control luminal breast cancer tumor progression by regulating different targets. Cell Cycle (2014) 0.79

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche. PLoS Biol (2016) 0.78

Molecular architecture and function of the hemidesmosome. Cell Tissue Res (2015) 0.77

PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736. PLoS One (2015) 0.76

Combining GWAS and RNA-Seq Approaches for Detection of the Causal Mutation for Hereditary Junctional Epidermolysis Bullosa in Sheep. PLoS One (2015) 0.76

Roles of Integrin α6β4 Glycosylation in Cancer. Cancers (Basel) (2017) 0.75

Articles cited by this

A novel genetic system to detect protein-protein interactions. Nature (1989) 43.83

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell (1993) 33.20

Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics (1996) 24.62

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev (1993) 17.09

Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast (1995) 13.20

Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol (1987) 12.66

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J Virol (1989) 8.68

Structure and function of intercellular junctions. Int Rev Cytol (1974) 8.14

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol (1989) 6.55

Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits. J Cell Biol (1987) 4.85

F-actin binding site masked by the intramolecular association of vinculin head and tail domains. Nature (1995) 4.07

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol (1996) 3.68

Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell (1991) 3.55

Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. Nat Genet (1996) 3.52

Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat Genet (1996) 3.42

Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol (1991) 3.30

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate. Nature (1996) 3.26

Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J Cell Biol (1990) 3.00

A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody. J Biol Chem (1987) 2.94

Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell (1995) 2.75

Use of the two-hybrid system to identify the domain of p53 involved in oligomerization. Oncogene (1993) 2.33

Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture. Genes Dev (1997) 2.32

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. J Cell Biol (1990) 2.24

Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J (1990) 2.23

Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells. EMBO J (1990) 2.16

Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system. FASEB J (1993) 2.15

Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. J Cell Sci (1997) 2.11

An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell (1996) 2.09

Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J (1995) 2.00

Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J Invest Dermatol (1992) 1.99

Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Nat Genet (1995) 1.90

Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem (1989) 1.88

Plectin deficiency results in muscular dystrophy with epidermolysis bullosa. Nat Genet (1996) 1.78

Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization. Genes Dev (1996) 1.75

Basement membrane diversity detected by monoclonal antibodies. Differentiation (1984) 1.72

Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa. Nat Genet (1995) 1.71

Desmosomes and hemidesmosomes: structure and function of molecular components. FASEB J (1996) 1.70

Cloning of type XVII collagen. Complementary and genomic DNA sequences of mouse 180-kilodalton bullous pemphigoid antigen (BPAG2) predict an interrupted collagenous domain, a transmembrane segment, and unusual features in the 5'-end of the gene and the 3'-untranslated region of the mRNA. J Biol Chem (1993) 1.69

The alpha 6 beta 4 integrin is a receptor for both laminin and kalinin. Exp Cell Res (1994) 1.69

Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies. J Clin Invest (1988) 1.65

Cloning and sequencing of rat plectin indicates a 466-kD polypeptide chain with a three-domain structure based on a central alpha-helical coiled coil. J Cell Biol (1991) 1.62

Identification of a new hemidesmosomal protein, HD1: a major, high molecular mass component of isolated hemidesmosomes. J Cell Biol (1992) 1.57

Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: recognition of laminin isoforms. Mol Biol Cell (1994) 1.56

Hemidesmosomes: roles in adhesion, signaling and human diseases. Curr Opin Cell Biol (1996) 1.56

Human bullous pemphigoid antigen (BPAG1). Amino acid sequences deduced from cloned cDNAs predict biologically important peptide segments and protein domains. J Biol Chem (1991) 1.55

Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q. Oncogene (1996) 1.53

Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins. J Cell Biol (1988) 1.53

Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin. J Biol Chem (1987) 1.50

Role of p150,95 in adhesion, migration, chemotaxis and phagocytosis of human monocytes. Eur J Immunol (1987) 1.48

Polarized expression of integrin receptors (alpha 6 beta 4, alpha 2 beta 1, alpha 3 beta 1, and alpha v beta 5) and their relationship with the cytoskeleton and basement membrane matrix in cultured human keratinocytes. J Cell Biol (1991) 1.47

A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins. J Cell Biol (1995) 1.46

The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes. Mol Biol Cell (1993) 1.45

Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy. J Clin Invest (1996) 1.45

Cytoplasmic domain of the 180-kD bullous pemphigoid antigen, a hemidesmosomal component: molecular and cell biologic characterization. J Invest Dermatol (1992) 1.44

Kalinin is more efficient than laminin in promoting adhesion of primary keratinocytes and some other epithelial cells and has a different requirement for integrin receptors. J Cell Biol (1994) 1.41

Formation of hemidesmosomes in cells of a transformed murine mammary tumor cell line and mechanisms involved in adherence of these cells to laminin and kalinin. J Cell Sci (1993) 1.40

HD4, a 180 kDa bullous pemphigoid antigen, is a major transmembrane glycoprotein of the hemidesmosome. J Biochem (1993) 1.40

The dermal-epidermal junction. Curr Opin Cell Biol (1997) 1.39

Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties. J Cell Sci (1996) 1.37

A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresia. J Clin Invest (1997) 1.35

A 300,000-mol-wt intermediate filament-associated protein in baby hamster kidney (BHK-21) cells. J Cell Biol (1985) 1.34

Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit. J Cell Biol (1993) 1.34

Signal transduction by the alpha 6 beta 4 integrin: charting the path between laminin binding and nuclear events. J Cell Sci (1996) 1.25

Production of rabbit antibodies against carboxy-terminal epitopes encoded by bullous pemphigoid cDNA. J Invest Dermatol (1990) 1.24

Biochemical analysis of two cell surface glycoprotein complexes, very common antigen 1 and very common antigen 2. Relationship to very late activation T cell antigens. J Biol Chem (1987) 1.23

Developmental changes in expression of contractile and cytoskeletal proteins in human aortic smooth muscle. J Biol Chem (1990) 1.23

A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells. J Cell Sci (1997) 1.17

180-kD bullous pemphigoid antigen (BP180) is deficient in generalized atrophic benign epidermolysis bullosa. J Clin Invest (1995) 1.16

Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin. J Cell Biol (1995) 1.13

Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells. Mol Biol Cell (1997) 1.09

Second generation monoclonal antibodies to the human integrin alpha 6 beta 4. Hybridoma (1990) 1.07

The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit. J Cell Biol (1997) 1.07

Homozygous alpha6 integrin mutation in junctional epidermolysis bullosa with congenital duodenal atresia. Hum Mol Genet (1997) 1.06

A novel hemidesmosomal plaque component: tissue distribution and incorporation into assembling hemidesmosomes in an in vitro model. Exp Cell Res (1991) 1.05

Ligand-independent role of the beta 4 integrin subunit in the formation of hemidesmosomes. J Cell Sci (1998) 1.01

The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin beta 4 subunit. J Cell Sci (1997) 0.97

IFAP 300 is common to desmosomes and hemidesmosomes and is a possible linker of intermediate filaments to these junctions. J Cell Biol (1994) 0.97

Defective integrin alpha 6 beta 4 expression in the skin of patients with junctional epidermolysis bullosa and pyloric atresia. J Invest Dermatol (1996) 0.95

Insulin-induced phosphorylation of the beta-4 integrin subunit expressed on murine metastatic carcinoma cells. Mol Carcinog (1989) 0.91

The basement membrane protein BM-600/nicein codistributes with kalinin and the integrin alpha 6 beta 4 in human cultured keratinocytes. Exp Cell Res (1993) 0.90

Role of the bullous pemphigoid antigen 180 (BP180) in the assembly of hemidesmosomes and cell adhesion--reexpression of BP180 in generalized atrophic benign epidermolysis bullosa keratinocytes. Exp Cell Res (1998) 0.90

In vitro differentiation and progression of mouse mammary tumor cells. Cancer Res (1986) 0.87

Laminin-5 and modulation of keratin cytoskeleton arrangement in FG pancreatic carcinoma cells: involvement of IFAP300 and evidence that laminin-5/cell interactions correlate with a dephosphorylation of alpha 6A integrin. Cell Motil Cytoskeleton (1997) 0.86

Hemidesmosome assembly assessed by expression of a wild-type integrin beta 4 cDNA in junctional epidermolysis bullosa keratinocytes. Lab Invest (1997) 0.83

Articles by these authors

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol (1999) 40.46

The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol (1995) 10.07

A general primer GP5+/GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings. J Clin Microbiol (1997) 6.09

Long-term nonsurgical management of Barrett's esophagus with high-grade dysplasia. Gastroenterology (2001) 5.80

Protection by endoscopy against death from colorectal cancer. A case-control study among veterans. Arch Intern Med (1995) 5.59

The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J Cell Biol (1998) 4.38

Colorectal cancer prevention 2000: screening recommendations of the American College of Gastroenterology. American College of Gastroenterology. Am J Gastroenterol (2000) 4.17

Function and interactions of integrins. Cell Tissue Res (2001) 4.13

Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med (1985) 3.73

Prevention of colorectal cancer by flexible endoscopy and polypectomy. A case-control study of 32,702 veterans. Ann Intern Med (1995) 3.54

Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. Nat Genet (1996) 3.52

Cadherin engagement regulates Rho family GTPases. J Biol Chem (2001) 3.47

Helicobacter-negative gastritis: a distinct entity unrelated to Helicobacter pylori infection. Aliment Pharmacol Ther (2014) 3.38

The prevalence of hemorrhoids and chronic constipation. An epidemiologic study. Gastroenterology (1990) 3.22

Group-specific differentiation between high- and low-risk human papillomavirus genotypes by general primer-mediated PCR and two cocktails of oligonucleotide probes. J Clin Microbiol (1995) 3.20

The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin. J Cell Biol (1990) 3.07

A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody. J Biol Chem (1987) 2.94

Structural and functional aspects of filamins. Biochim Biophys Acta (2001) 2.89

Distribution of 37 mucosotropic HPV types in women with cytologically normal cervical smears: the age-related patterns for high-risk and low-risk types. Int J Cancer (2000) 2.86

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci U S A (1994) 2.71

General primer-mediated polymerase chain reaction permits the detection of sequenced and still unsequenced human papillomavirus genotypes in cervical scrapes and carcinomas. Int J Cancer (1990) 2.69

Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol (1999) 2.64

Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol (1995) 2.41

Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines. J Biol Chem (1989) 2.34

Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor. Cell (1995) 2.32

Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J (1990) 2.23

Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J Biol Chem (1988) 2.20

AGA technical review: evaluation of dyspepsia. American Gastroenterological Association. Gastroenterology (1998) 2.19

Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors. Int J Cancer (1984) 2.12

Pancreatitis is a risk factor for pancreatic cancer. Gastroenterology (1995) 2.11

Temporal changes in the occurrence of hemorrhoids in the United States and England. Dis Colon Rectum (1991) 2.09

Processing of long-stored archival cervical smears for human papillomavirus detection by the polymerase chain reaction. Br J Cancer (1995) 2.00

The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. J Cell Biol (2000) 2.00

Gastric surgery is not a risk for Barrett's esophagus or esophageal adenocarcinoma. Gastroenterology (2001) 1.99

Opposing time trends of peptic ulcer and reflux disease. Gut (1998) 1.99

Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem (1989) 1.88

Clinical epidemiology of chronic constipation. J Clin Gastroenterol (1989) 1.85

Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules. J Cell Biol (1990) 1.85

A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis. Nat Genet (2001) 1.83

Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Int J Cancer (2001) 1.82

Predictors of duodenal ulcer healing and relapse. Gastroenterology (1981) 1.78

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med (1997) 1.75

Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. Am J Hum Genet (2001) 1.71

Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity. EMBO J (1987) 1.69

The alpha 6 beta 4 integrin is a receptor for both laminin and kalinin. Exp Cell Res (1994) 1.69

Epidemiology and practice patterns of achalasia in a large multi-centre database. Aliment Pharmacol Ther (2011) 1.67

Analysis of cytomorphologically abnormal cervical scrapes for the presence of 27 mucosotropic human papillomavirus genotypes, using polymerase chain reaction. Int J Cancer (1994) 1.67

Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology (1997) 1.66

Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol (1999) 1.64

Stage-specific expression and genomic organization of the actin genes of the malaria parasite Plasmodium falciparum. Mol Biochem Parasitol (1989) 1.64

Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J Cell Biol (1999) 1.64

The extracellular domain of BPAG2 localizes to anchoring filaments and its carboxyl terminus extends to the lamina densa of normal human epidermal basement membrane. J Invest Dermatol (1997) 1.63

Development of mouse mammary gland: identification of stages in differentiation of luminal and myoepithelial cells using monoclonal antibodies and polyvalent antiserum against keratin. J Histochem Cytochem (1986) 1.61

Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. Clin Cancer Res (2001) 1.60

Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: recognition of laminin isoforms. Mol Biol Cell (1994) 1.56

Hemidesmosomes: roles in adhesion, signaling and human diseases. Curr Opin Cell Biol (1996) 1.56

The gene for triphalangeal thumb maps to the subtelomeric region of chromosome 7q. Nat Genet (1994) 1.56

Efficient management of diarrhea in the acquired immunodeficiency syndrome (AIDS). A medical decision analysis. Ann Intern Med (1990) 1.55

Management of bullous pemphigoid: the European Dermatology Forum consensus in collaboration with the European Academy of Dermatology and Venereology. Br J Dermatol (2015) 1.55

Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridisation. J Clin Pathol (1998) 1.54

Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q. Oncogene (1996) 1.53

Biology and function of hemidesmosomes. Matrix Biol (1999) 1.51

A non-radioactive PCR enzyme-immunoassay enables a rapid identification of HPV 16 and 18 in cervical scrapes after GP5+/6+ PCR. J Med Virol (1996) 1.47

Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins. J Cell Sci (2000) 1.46

Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol (2000) 1.45

Geographic and temporal variations in the occurrence of peptic ulcer disease. Scand J Gastroenterol Suppl (1985) 1.45

Analysis of type-restricted and cross-reactive epitopes on virus-like particles of human papillomavirus type 33 and in infected tissues using monoclonal antibodies to the major capsid protein. J Gen Virol (1994) 1.44

Ethnic variations in the occurrence of gastroesophageal cancers. J Clin Gastroenterol (1999) 1.43

Military history of patients with inflammatory bowel disease: an epidemiological study among U.S. veterans. Am J Gastroenterol (1998) 1.42

Limitations of the faecal occult blood test in screening for colorectal cancer. Ital J Gastroenterol Hepatol (1999) 1.42

P-selectin mediates Ca(2+)-dependent adhesion of activated platelets to many different types of leukocytes: detection by flow cytometry. Blood (1992) 1.41

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes. Mol Biol Cell (2003) 1.41

Formation of hemidesmosomes in cells of a transformed murine mammary tumor cell line and mechanisms involved in adherence of these cells to laminin and kalinin. J Cell Sci (1993) 1.40

Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits. Dev Biol (2001) 1.38

Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes. Eur J Biochem (1991) 1.38

Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties. J Cell Sci (1996) 1.37

Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit. J Cell Biol (1993) 1.34

Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line. Cancer Res (1995) 1.29

Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA. Cancer Res (1998) 1.27

The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. J Biol Chem (2000) 1.27

Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin. J Biol Chem (1991) 1.26

Reliable high risk HPV DNA testing by polymerase chain reaction: an intermethod and intramethod comparison. J Clin Pathol (1999) 1.26

Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1. FEBS Lett (1990) 1.26

Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer. Gut (1983) 1.25

Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. J Biol Chem (1992) 1.24

Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events. Bioessays (1999) 1.24

alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development. J Cell Sci (2000) 1.23

Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development. J Cell Biol (1998) 1.23

Corpus gastritis is protective against reflux oesophagitis. Gut (1999) 1.23

Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer. Am J Gastroenterol (2001) 1.23