Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4632022)

Published in Sci Rep on November 04, 2015

Authors

Satomi Mukai1, Norikazu Yabuta1, Kaori Yoshida1, Ayumi Okamoto1, Daisaku Miura2, Yasuhide Furuta3,4, Takaya Abe3, Hiroshi Nojima1

Author Affiliations

1: Department of Molecular Genetics Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita City, Osaka 565-0871, Japan.
2: Department of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan.
3: Animal Resource Development Unit, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
4: Genetic Engineering Team, RIKEN Center for Life Science Technologies, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

Articles citing this

The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway. Cell Death Differ (2017) 0.75

Articles cited by this

Principles of CDK regulation. Nature (1995) 13.09

The hippo signaling pathway in development and cancer. Dev Cell (2010) 10.54

A mechanism linking extra centrosomes to chromosomal instability. Nature (2009) 9.45

Ubiquitin-binding domains. Biochem J (2006) 5.32

Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science (1999) 4.69

Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet (1999) 4.23

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell (2000) 3.91

Centrosome biogenesis and function: centrosomics brings new understanding. Nat Rev Mol Cell Biol (2007) 3.83

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat Cell Biol (1999) 3.74

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One (2009) 3.36

Centrosome defects and genetic instability in malignant tumors. Cancer Res (1998) 3.32

Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proc Natl Acad Sci U S A (1998) 3.23

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet (1999) 2.60

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev (2006) 2.41

Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol (2000) 2.36

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J (2004) 2.18

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci (2004) 1.93

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Nat Cell Biol (2004) 1.86

Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. J Biol Chem (2001) 1.80

LATS tumor suppressor: a new governor of cellular homeostasis. Cell Cycle (2010) 1.78

Lats2 is an essential mitotic regulator required for the coordination of cell division. J Biol Chem (2007) 1.75

The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. Cell Cycle (2011) 1.69

Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat Cell Biol (2010) 1.64

Mechanisms and pathways of growth failure in primordial dwarfism. Genes Dev (2011) 1.56

RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2. Nat Cell Biol (2014) 1.53

Human LATS1 is a mitotic exit network kinase. Cancer Res (2005) 1.50

Centrosome-associated NDR kinase regulates centrosome duplication. Mol Cell (2007) 1.37

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells (2004) 1.35

Centrosome amplification causes microcephaly. Nat Cell Biol (2013) 1.33

Molecular dissection of the centrosome overduplication pathway in S-phase-arrested cells. Mol Cell Biol (2009) 1.24

Two for two: Cdk2 and its role in centrosome doubling. Oncogene (2002) 1.18

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. FEBS Lett (1999) 1.17

CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage. J Cell Sci (2006) 1.16

CDC25B involvement in the centrosome duplication cycle and in microtubule nucleation. Cancer Res (2007) 1.06

The centrosome duplication cycle in health and disease. FEBS Lett (2014) 1.06

Centrosome clustering and chromosomal (in)stability: a matter of life and death. Mol Oncol (2011) 0.97

CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. Cell Cycle (2005) 0.94

WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. FEBS Lett (2002) 0.89

Cancer cell micronucleus: an update on clinical and diagnostic applications. APMIS (2012) 0.88

Multiple splicing variants of cdc25B regulate G2/M progression. Biochem Biophys Res Commun (1999) 0.86

N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability. J Cell Sci (2012) 0.85

CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci. PLoS One (2013) 0.83

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer. Protein Cell (2014) 0.83

CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity. Biol Cell (2011) 0.78