Published in Genes Dev on October 01, 2006
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Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell (2014) 3.15
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev (2008) 2.48
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell (2008) 2.46
p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A (2010) 1.77
Cell fusion induced by ERVWE1 or measles virus causes cellular senescence. Genes Dev (2013) 1.77
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor. Mol Biol Cell (2011) 1.75
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Lats2 is a negative regulator of myocyte size in the heart. Circ Res (2008) 1.53
The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. Genes Dev (2010) 1.50
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Merlin is a potent inhibitor of glioma growth. Cancer Res (2008) 1.47
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Efficient genetic method for establishing Drosophila cell lines unlocks the potential to create lines of specific genotypes. PLoS Genet (2008) 1.30
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J (2011) 1.26
p53: guardian of ploidy. Mol Oncol (2011) 1.25
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Mol Cell (2012) 1.24
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Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival. Curr Protein Pept Sci (2010) 1.21
ATM regulates a RASSF1A-dependent DNA damage response. Curr Biol (2009) 1.14
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Cell-cycle progression without an intact microtuble cytoskeleton. Curr Biol (2007) 1.10
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling. Cell Biosci (2013) 1.09
The PIDDosome activates p53 in response to supernumerary centrosomes. Genes Dev (2017) 1.07
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p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology (2013) 1.05
p53 suppresses structural chromosome instability after mitotic arrest in human cells. Oncogene (2010) 1.05
Centrosomes, chromosome instability (CIN) and aneuploidy. Curr Opin Cell Biol (2012) 1.04
CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation. Cancer Res (2013) 1.03
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Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison. Biochem Pharmacol (2007) 1.02
Stability of the LATS2 tumor suppressor gene is regulated by tristetraprolin. J Biol Chem (2010) 1.01
Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression. Silence (2011) 0.98
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer (2008) 0.97
LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction. Cell Rep (2013) 0.95
Tumor suppressor protein p53 regulates megakaryocytic polyploidization and apoptosis. J Biol Chem (2008) 0.94
Selective killing of p53-deficient cancer cells by SP600125. EMBO Mol Med (2012) 0.94
A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators. Br J Cancer (2008) 0.94
A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma. Cancer Res (2012) 0.93
Genome-wide impact of a recently expanded microRNA cluster in mouse. Proc Natl Acad Sci U S A (2011) 0.92
Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins. Open Biol (2015) 0.92
The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle (2012) 0.90
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint. J Biol Chem (2008) 0.87
A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination. FEBS Lett (2010) 0.86
p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells. PLoS One (2011) 0.86
Characterization of the p53 response to oncogene-induced senescence. PLoS One (2008) 0.86
Failure of cell cleavage induces senescence in tetraploid primary cells. Mol Biol Cell (2014) 0.86
Testicular cancer: biology and biomarkers. Virchows Arch (2014) 0.86
Yes-associated protein (YAP) modulates oncogenic features and radiation sensitivity in endometrial cancer. PLoS One (2014) 0.85
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Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse. Open Biol (2015) 0.83
Ras signaling through RASSF proteins. Semin Cell Dev Biol (2016) 0.82
Lats2 is critical for the pluripotency and proper differentiation of stem cells. Cell Death Differ (2014) 0.82
Hypermethylation of the large tumor suppressor genes in Japanese lung cancer. Oncol Lett (2010) 0.82
Down-regulation of LATS kinases alters p53 to promote cell migration. Genes Dev (2015) 0.81
Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth. Cell Death Differ (2015) 0.81
Alteration of TEAD1 expression levels confers apoptotic resistance through the transcriptional up-regulation of Livin. PLoS One (2012) 0.81
MicroRNA-135b regulates apoptosis and chemoresistance in colorectal cancer by targeting large tumor suppressor kinase 2. Am J Cancer Res (2015) 0.81
CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity. Oncotarget (2015) 0.80
MicroRNAs, genomic instability and cancer. Int J Mol Sci (2014) 0.80
Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation. J Biol Chem (2012) 0.79
Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis. J Biol Chem (2016) 0.79
LATS2 is de-methylated and overexpressed in nasopharyngeal carcinoma and predicts poor prognosis. BMC Cancer (2010) 0.78
The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation. Genes Dev (2016) 0.78
Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis. Cell Cycle (2015) 0.77
Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation. J Ophthalmol (2016) 0.76
The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res (2016) 0.76
Large tumor suppressors 1 and 2 regulate Aurora-B through phosphorylation of INCENP to ensure completion of cytokinesis. Heliyon (2016) 0.76
RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver. J Hepatol (2015) 0.76
LATS2 Positively Regulates Polycomb Repressive Complex 2. PLoS One (2016) 0.75
Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B. Sci Rep (2015) 0.75
A genetic variant in large tumor suppressor kinase 2 of Hippo signaling pathway contributes to prognosis of hepatocellular carcinoma. Onco Targets Ther (2016) 0.75
microRNAs with AAGUGC seed motif constitute an integral part of an oncogenic signaling network. Oncogene (2016) 0.75
Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas. Lung Cancer (2014) 0.75
Contribution of LATS1 and LATS2 promoter methylation in OSCC development. J Cell Commun Signal (2016) 0.75
Developing a Gene Biomarker at the Tipping Point of Adaptive and Adverse Responses in Human Bronchial Epithelial Cells. PLoS One (2016) 0.75
An identity crisis for a cancer gene: subcellular location determines ASPP1 function. Cancer Cell (2010) 0.75
The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair. Genes (Basel) (2016) 0.75
Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis. Int J Mol Sci (2017) 0.75
Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate. Aging (Albany NY) (2011) 0.75
The Hippo pathway, p53 and cholesterol. Cell Cycle (2016) 0.75
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway. Cell Death Differ (2017) 0.75
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42
Live or let die: the cell's response to p53. Nat Rev Cancer (2002) 15.06
Definition of a consensus binding site for p53. Nat Genet (1992) 12.76
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell (2006) 11.01
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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
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Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Clin Cancer Res (2005) 2.67
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G1 tetraploidy checkpoint and the suppression of tumorigenesis. J Cell Biochem (2003) 2.01
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Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Oncogene (2004) 1.86
Lats2, a putative tumor suppressor, inhibits G1/S transition. Oncogene (2003) 1.82
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The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Biochem Biophys Res Commun (2006) 1.58
Human LATS1 is a mitotic exit network kinase. Cancer Res (2005) 1.50
Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics (2000) 1.40
LATS1 tumor suppressor regulates G2/M transition and apoptosis. Oncogene (2002) 1.38
The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells (2004) 1.35
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Triggering p53 after cytokinesis failure. J Cell Biol (2004) 1.27
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Cell cycle checkpoint control mechanisms that can be disrupted in cancer. Methods Mol Biol (2004) 1.02
Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). Exp Cell Res (2004) 1.00
Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. Oncogene (2000) 0.99
Isolation and characterization of sixteen novel p53 response genes. Oncogene (2000) 0.96
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Chromosome damage and progression into and through mitosis in vertebrates. DNA Repair (Amst) (2004) 0.95
The role of p53 in the response to mitotic spindle damage. Pathol Biol (Paris) (2000) 0.93
Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. Oncogene (2001) 0.92
Membrane recruitment systems for analysis of protein-protein interactions. Methods Mol Biol (2001) 0.86
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell (2006) 11.01
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell (2007) 9.51
The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell (2009) 5.19
The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol (2003) 4.46
Global and local architecture of the mammalian microRNA-transcription factor regulatory network. PLoS Comput Biol (2007) 4.31
A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell (2006) 3.98
Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells. Nat Cell Biol (2008) 3.08
Living with p53, dying of p53. Cell (2007) 2.62
Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene (2002) 2.50
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell (2006) 2.50
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev (2008) 2.48
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell (2008) 2.46
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope. Nat Immunol (2003) 2.38
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell (2007) 2.32
DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. Oncogene (2002) 2.27
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Genes Cancer (2011) 2.18
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol Cell (2004) 2.16
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
The p53 and Mdm2 families in cancer. Curr Opin Genet Dev (2002) 2.07
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol (2008) 2.04
Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol (2004) 2.04
Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell (2010) 1.95
Physical interaction with human tumor-derived p53 mutants inhibits p63 activities. J Biol Chem (2002) 1.91
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90
Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals. Mol Cell (2011) 1.89
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell (2013) 1.86
p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A (2010) 1.77
Lats2 is an essential mitotic regulator required for the coordination of cell division. J Biol Chem (2007) 1.75
CKIα ablation highlights a critical role for p53 in invasiveness control. Nature (2011) 1.72
CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. EMBO Rep (2009) 1.69
The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. Cell Cycle (2011) 1.69
Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells. Cancer Res (2007) 1.64
Transactivation of the EGR1 gene contributes to mutant p53 gain of function. Cancer Res (2004) 1.59
Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice. J Invest Dermatol (2007) 1.54
Lats2 is a negative regulator of myocyte size in the heart. Circ Res (2008) 1.53
RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Mol Cell (2012) 1.52
The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. Genes Dev (2010) 1.50
p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts. Cancer Res (2006) 1.48
Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J (2002) 1.45
p53 and p21 regulate error-prone DNA repair to yield a lower mutation load. Mol Cell (2006) 1.44
A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochem Biophys Res Commun (2003) 1.37
Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy. Cell Cycle (2008) 1.36
The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells (2004) 1.35
hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis. Cancer Res (2006) 1.33
Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation. Eur J Pharmacol (2002) 1.32
SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. Blood (2002) 1.32
Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. DNA Res (2006) 1.31
Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A (2012) 1.30
Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants. Oncogene (2003) 1.28
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J (2011) 1.26
p53: guardian of ploidy. Mol Oncol (2011) 1.25
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Mol Cell (2012) 1.24
Inhibition of p53 degradation by Mdm2 acetylation. FEBS Lett (2004) 1.24
Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice. Eur J Pharmacol (2005) 1.24
PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells. Biochem Biophys Res Commun (2008) 1.24
RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. Mol Cell (2011) 1.23
Itch-associated response induced by experimental dry skin in mice. Jpn J Pharmacol (2002) 1.23
A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell (2013) 1.22
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2. Proc Natl Acad Sci U S A (2008) 1.22
The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast. EMBO J (2002) 1.21
Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients. DNA Res (2006) 1.20
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Proc Natl Acad Sci U S A (2003) 1.20
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. Proc Natl Acad Sci U S A (2007) 1.19
p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy. Genome Res (2010) 1.19
DNA damage-induced translocation of the Werner helicase is regulated by acetylation. J Biol Chem (2002) 1.19
New plays in the p53 theater. Curr Opin Genet Dev (2010) 1.19
Noise-mean relationship in mutated promoters. Genome Res (2012) 1.18
Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein. Genes Cells (2002) 1.18
Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem (2012) 1.18
Pathways and therapeutic targets in melanoma. Oncotarget (2014) 1.17
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest (2012) 1.16
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Adv Exp Med Biol (2007) 1.15
GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression. J Cell Sci (2009) 1.15
Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics. Oncogene (2004) 1.13
p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner. Cancer Res (2010) 1.12
The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis. Genes Cells (2006) 1.11
4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells. Genome Biol (2014) 1.10
Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter. Proc Natl Acad Sci U S A (2004) 1.10
Fission yeast meu14+ is required for proper nuclear division and accurate forespore membrane formation during meiosis II. J Cell Sci (2003) 1.10
Aberrant expression of connexin 26 is associated with lung metastasis of colorectal cancer. Clin Cancer Res (2008) 1.08
CD74 induces TAp63 expression leading to B-cell survival. Blood (2007) 1.08
Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate. Aging (Albany NY) (2009) 1.07
Use of stepwise subtraction to comprehensively isolate mouse genes whose transcription is up-regulated during spermiogenesis. EMBO Rep (2002) 1.07