Published in Proc Natl Acad Sci U S A on February 01, 1977
A highly polymorphic locus in human DNA. Proc Natl Acad Sci U S A (1980) 10.27
The detection of DNA-binding proteins by protein blotting. Nucleic Acids Res (1980) 7.84
Extracellular nucleases of pseudomonas BAL 31. III. Use of the double-strand deoxyriboexonuclease activity as the basis of a convenient method for the mapping of fragments of DNA produced by cleavage with restriction enzymes. Nucleic Acids Res (1978) 5.62
Restriction enzymes and their isoschizomers. Nucleic Acids Res (1990) 4.24
A simple, general procedure for purifying restriction endonucleases. Nucleic Acids Res (1977) 4.16
Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1985) 3.53
Promoter mutations in the transfer RNA gene tyrT of Escherichia coli. Proc Natl Acad Sci U S A (1979) 2.89
Regulation of the threonine operon: tandem threonine and isoleucine codons in the control region and translational control of transcription termination. Proc Natl Acad Sci U S A (1979) 2.77
Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1980) 2.56
Physical and gene mapping of chloroplast DNA from Atriplex triangularis and Cucumis sativa. Nucleic Acids Res (1982) 2.35
A computer assisted method for the determination of restriction enzyme recognifion sites. Nucleic Acids Res (1978) 2.32
ClaI. a new restriction endonuclease from Caryophanon latum L. Nucleic Acids Res (1981) 2.21
A specific endonuclease from Bacillus caldolyticus. Nucleic Acids Res (1978) 2.18
An analysis of cosmid clones of nuclear DNA from Trypanosoma brucei shows that the genes for variant surface glycoproteins are clustered in the genome. Nucleic Acids Res (1982) 2.16
The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end. Nucleic Acids Res (1983) 2.10
Evidence for a disseminated plasmid in Streptococcus mutans. Infect Immun (1978) 2.09
Purification and characterization of two new modification methylases: MClaI from Caryophanon latum L and MTaqI from Thermus aquaticus YTI. Nucleic Acids Res (1981) 2.05
Location of Homologous DNA Sequences Interspersed at Five Regions in the Baculovirus AcMNPV Genome. J Virol (1983) 2.01
Automatic construction of restriction site maps. Nucleic Acids Res (1982) 1.92
Rearrangements in the chloroplast genomes of mung bean and pea. Proc Natl Acad Sci U S A (1981) 1.89
Origin and direction of DNA replication of plasmid RSF1030. Proc Natl Acad Sci U S A (1979) 1.76
Cloning, sequencing and expression of the Taq I restriction-modification system. Nucleic Acids Res (1987) 1.71
Restriction enzymes and their isoschizomers. Nucleic Acids Res (1989) 1.71
Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1981) 1.67
DNA sequence of the araC regulatory gene from Escherichia coli B/r. Nucleic Acids Res (1980) 1.62
Nucleosome-like structural subunits of intranuclear parental adenovirus type 2 DNA. J Virol (1979) 1.54
Restriction enzymes and their isoschizomers. Nucleic Acids Res (1988) 1.47
Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1982) 1.42
Purification and characterization of an isoschizomer of Asu II from Clostridium sporogenes. Nucleic Acids Res (1989) 1.40
Mouse heavy chain variable regions: nucleotide sequence of a germ-line VH gene segment. Nucleic Acids Res (1981) 1.38
A second type II restriction endonuclease from Thermus aquaticus with an unusual sequence specificity. Nucleic Acids Res (1984) 1.38
RsaI: a new sequence-specific endonuclease activity from Rhodopseudomonas sphaeroides. J Bacteriol (1980) 1.34
DNA primase activity associated with DNA polymerase alpha from Xenopus laevis ovaries. Proc Natl Acad Sci U S A (1982) 1.25
Detection of labelled RNA species by contact hybridization. Nucleic Acids Res (1979) 1.18
Restriction and modification in Bacillus subtilis: sequence specificities of restriction/modification systems BsuM, BsuE, and BsuF. J Bacteriol (1983) 1.13
Degrees of relatedness of T-even type E. coli phages using different or the same receptors and topology of serologically cross-reacting sites. EMBO J (1983) 1.11
DNA sequences of the integration sites and inverted repeated structure of transposon Tn3. Nucleic Acids Res (1979) 1.08
Attenuation regulation in the thr operon of Escherichia coli K-12: molecular cloning and transcription of the controlling region. J Bacteriol (1982) 1.04
DNA organisation in the chicken lysozyme gene region. Nucleic Acids Res (1981) 1.01
Characterization of the molecular components in kinetoplast-mitochondrial DNA of Trypanosoma equiperdum. Comparative study of the dyskinetoplastic and wild strains. J Cell Biol (1979) 0.99
Bifunctional TaqII restriction endonuclease: redefining the prototype DNA recognition site and establishing the Fidelity Index for partial cleaving. BMC Biochem (2011) 0.98
Two distinct intervening sequences in different ribosomal DNA repeat units of Sciara coprophila. Nucleic Acids Res (1981) 0.97
The human thyroglobulin gene is over 300 kb long and contains introns of up to 64 kb. Nucleic Acids Res (1986) 0.96
Presence of N6-methyladenine in GATC sequences of Bacillus popilliae and Bacillus lentimorbus KLN2. J Bacteriol (1990) 0.91
Secondary lambda attachment site in the threonine operon attenuator of Escherichia coli. J Bacteriol (1981) 0.90
Restriction endonuclease mapping by crossed contact hybridization: the ribosomal RNA genes of Achlya ambisexualis. Nucleic Acids Res (1979) 0.90
Characterization of a site-specific restriction endonuclease from Streptomyces aureofaciens. J Bacteriol (1981) 0.90
Effect of Lactose Concentration on the Efficiency of Plating of Bacteriophages on Streptococcus cremoris. Appl Environ Microbiol (1978) 0.86
Physical map of bacteriophage BF23 DNA: restriction enzyme analysis. J Virol (1979) 0.86
Protein engineering of a cold-active beta-galactosidase from Arthrobacter sp. SB to increase lactose hydrolysis reveals new sites affecting low temperature activity. Extremophiles (2006) 0.85
Part I: characterization of the extracellular proteome of the extreme thermophile Caldicellulosiruptor saccharolyticus by GeLC-MS2. Anal Bioanal Chem (2010) 0.83
Robust Real-Time Reverse Transcription-PCR for Detection of Foot-and-Mouth Disease Virus Neutralizing Carryover Contamination. J Clin Microbiol (2015) 0.75
Evolution of bacteriophage phi C174. V. Alignment of the phi X174, G4, and St-1 restriction enzyme cleavage maps. J Virol (1978) 0.75
A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J Mol Biol (1975) 90.35
Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A (1975) 56.75
Molecular weight estimation and separation of ribonucleic acid by electrophoresis in agarose-acrylamide composite gels. Biochemistry (1968) 21.08
A restriction enzyme from Hemophilus influenzae. I. Purification and general properties. J Mol Biol (1970) 19.69
Restriction endonucleases in the analysis and restructuring of dna molecules. Annu Rev Biochem (1975) 11.76
Thermus aquaticus gen. n. and sp. n., a nonsporulating extreme thermophile. J Bacteriol (1969) 8.40
Specific fragments of phi X174 deoxyribonucleic acid produced by a restriction enzyme from Haemophilus aegyptius, endonuclease Z. J Virol (1972) 8.22
A second specific endonuclease from Haemophilus aegyptius. J Mol Biol (1975) 6.36
The mapping and sequence determination of the single site in phiX174am3 replicative form DNA cleaved by restriction endonuclease Pst I. FEBS Lett (1976) 3.31
The location of the repressor binding sites in the lac operon. Proc Natl Acad Sci U S A (1974) 2.64
A restriction cleavage map of phiX 174 DNA by pulse-chase labelling using E. coli DNA polymerase. Nucleic Acids Res (1976) 1.65
Purification by affinity chromatography of thermostable glyceraldehyde 3-phosphate dehydrogenase from Thermus aquaticus. FEBS Lett (1973) 1.21
The sequence of the human genome. Science (2001) 101.55
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
Activation tagging in Arabidopsis. Plant Physiol (2000) 7.09
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol (2001) 5.27
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci U S A (2000) 4.41
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev (1998) 4.29
Endoscopic papillary balloon dilation for the management of common bile duct stones: experience of 226 cases. Endoscopy (1998) 4.11
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10
Cloning of a Streptococcus mutans glucosyltransferase gene coding for insoluble glucan synthesis. Infect Immun (1986) 4.08
Acute axonal polyneuropathy associated with anti-GM1 antibodies following Campylobacter enteritis. Neurology (1990) 3.91
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Safety and cognitive effect of frontal DC brain polarization in healthy individuals. Neurology (2005) 3.74
Discovery of a cool planet of 5.5 Earth masses through gravitational microlensing. Nature (2006) 3.53
The use of maleic anhydride for the reversible blocking of amino groups in polypeptide chains. Biochem J (1969) 3.07
Language dominance in partial epilepsy patients identified with an fMRI reading task. Neurology (2002) 2.98
Production of large amounts of antibodies in individual mice. J Immunol (1976) 2.93
Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica. Neurology (2005) 2.77
Diffusion-weighted MRI abnormalities as an early diagnostic marker for Creutzfeldt-Jakob disease. Neurology (2004) 2.76
Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity (1995) 2.69
ARR1, a transcription factor for genes immediately responsive to cytokinins. Science (2001) 2.50
The secondarily generalized tonic-clonic seizure: a videotape analysis. Neurology (1994) 2.50
PTEN1 is frequently mutated in primary endometrial carcinomas. Nat Genet (1997) 2.44
Episome-mediated Transfer of Drug Resistance in Enterobacteriaceae X. Restriction and Modification of Phages by fi R Factors. J Bacteriol (1966) 2.43
Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus. Nature (1977) 2.42
Amino-acid sequence of glyceraldehyde 3-phosphate dehydrogenase from lobster muscle. Nature (1967) 2.40
Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci (1998) 2.39
A large scale analysis of cDNA in Arabidopsis thaliana: generation of 12,028 non-redundant expressed sequence tags from normalized and size-selected cDNA libraries. DNA Res (2000) 2.33
Reversible blocking of peptide amino groups by maleic anhydride. Biochem J (1967) 2.31
Motoneuron-disease-like disorder after ganglioside therapy. Lancet (1991) 2.30
Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells. Int Immunol (1991) 2.27
Astrocytic damage is far more severe than demyelination in NMO: a clinical CSF biomarker study. Neurology (2010) 2.24
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16
Conjunction search revisited. J Exp Psychol Hum Percept Perform (1990) 2.15
Body mass index in male patients with COPD: correlation with low attenuation areas on CT. Thorax (2008) 2.12
Discovery of a Jupiter/Saturn analog with gravitational microlensing. Science (2008) 2.09
Substrate recognition by ADAR1 and ADAR2. RNA (2001) 2.09
Initial events of myelination involve Fyn tyrosine kinase signalling. Nature (1994) 2.08
Six family genes--structure and function as transcription factors and their roles in development. Bioessays (2000) 2.03
Trends for coronary heart disease and stroke and their risk factors in Japan. Circulation (1989) 2.01
Glyceraldehyde 3-phosphate dehydrogenase from pig muscle. Nature (1968) 2.00
The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity (1997) 2.00
A DNA methylase from Thermus thermophilus HB8. J Biochem (1980) 2.00
CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. Annu Rev Immunol (1997) 1.99
Role of the putative membrane-bound endo-1,4-beta-glucanase KORRIGAN in cell elongation and cellulose synthesis in Arabidopsis thaliana. Plant Cell Physiol (2001) 1.97
Frequent presence of anti-GQ1b antibody in Fisher's syndrome. Neurology (1993) 1.96
Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol (1999) 1.96
The AHK4 gene involved in the cytokinin-signaling pathway as a direct receptor molecule in Arabidopsis thaliana. Plant Cell Physiol (2001) 1.94
Lingual and buccal mandibular bone depressions: a review based on 583 cases from a world-wide literature survey, including 69 new cases from Japan. Dentomaxillofac Radiol (2002) 1.93
Overexpression of an Arabidopsis thaliana high-affinity phosphate transporter gene in tobacco cultured cells enhances cell growth under phosphate-limited conditions. Proc Natl Acad Sci U S A (1997) 1.91
Possible relationship of a 36-megadalton Salmonella enteritidis plasmid to virulence in mice. Infect Immun (1985) 1.91
A large scale structural analysis of cDNAs in a unicellular green alga, Chlamydomonas reinhardtii. I. Generation of 3433 non-redundant expressed sequence tags. DNA Res (1999) 1.90
Atypical language in lesional and nonlesional complex partial epilepsy. Neurology (2007) 1.88
Resistance of Fc receptor- deficient mice to fatal glomerulonephritis. J Clin Invest (1998) 1.88
High seroprevalence of Helicobacter pylori infection in patients with systemic sclerosis: association with esophageal involvement. J Rheumatol (1998) 1.86
Nocturnal intermittent hypoxia and the development of type 2 diabetes: the Circulatory Risk in Communities Study (CIRCS). Diabetologia (2009) 1.85
Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science (2001) 1.84
Periodic limb movements in sleep: state-dependent excitability of the spinal flexor reflex. Neurology (2000) 1.83
A new immunologic marker for human Langerhans cells. N Engl J Med (1981) 1.79
The amino acid sequences of erabutoxins, neurotoxic proteins of sea-snake (Laticauda semifasciata) venom. Biochem J (1971) 1.79
Cross-cultural comparison of the sleep-disordered breathing prevalence among Americans and Japanese. Eur Respir J (2010) 1.79
Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol (1996) 1.79
Primary hepatic lymphoma associated with primary biliary cirrhosis. Am J Gastroenterol (1999) 1.77
Melasma: a clinical, light microscopic, ultrastructural, and immunofluorescence study. J Am Acad Dermatol (1981) 1.76
Increased von Willebrand factor in the endocardium as a local predisposing factor for thrombogenesis in overloaded human atrial appendage. J Am Coll Cardiol (2001) 1.75
Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation and biological properties of fortimicins. J Antibiot (Tokyo) (1977) 1.74
Characterization of Langerhans cells by the use of monoclonal antibodies. Lab Invest (1981) 1.73
Construction of a genetic linkage map of the model legume Lotus japonicus using an intraspecific F2 population. DNA Res (2001) 1.72
Relation between initial blood distribution volume and propofol induction dose requirement. Anesthesiology (2001) 1.68
Enzymatic acetylation of fortimicin A and seldomycin factor 5 by aminoglycoside 3-acetyltransferase I: [AAC(3)-I] of E. coli KY8348. J Antibiot (Tokyo) (1977) 1.67
Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments. FEBS Lett (1993) 1.67
Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. Mol Cell Biol (1999) 1.66
Interferon associated retinopathy. Br J Ophthalmol (1998) 1.65
Extrahepatic portosystemic venous shunt without portal hypertension. Intern Med (1997) 1.64
Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain. Nature (1978) 1.63
Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma. Clin Cancer Res (2001) 1.63
Ultrastructural observations of the capsule of chronic subdural hematoma in various clinical stages. J Neurosurg (1975) 1.61
Systematic review and meta-analysis: importance of CagA status for successful eradication of Helicobacter pylori infection. Aliment Pharmacol Ther (2006) 1.60
Phosphofructokinase: complete amino-acid sequence of the enzyme from Bacillus stearothermophilus. Eur J Biochem (1980) 1.59
Triose phosphate isomerase from the coelacanth. An approach to the rapid determination of an amino acid sequence with small amounts of material. Biochem J (1974) 1.59
Chemosensitivity and p53-Bax pathway-mediated apoptosis in patients with uterine cervical cancer. Ann Oncol (2003) 1.58
A spite specific endonuclease from thermus thermophilus 111, Tth111I. Nucleic Acids Res (1980) 1.57
HLA-B35 and acute axonal polyneuropathy following Campylobacter infection. Neurology (1991) 1.56
D-glyceraldehyde-3-phosphate dehydrogenase. Amino-acid sequence of the enzyme from the extreme thermophile Thermus aquaticus. Eur J Biochem (1980) 1.55
Transforming growth factor beta1 gene polymorphism in rheumatoid arthritis. Ann Rheum Dis (2002) 1.54
Age and comorbidity as risk factors for vocal cord paralysis associated with tracheal intubation. Br J Anaesth (2007) 1.54
Ursodeoxycholic acid inhibits eosinophil degranulation in patients with primary biliary cirrhosis. Hepatology (1999) 1.54
Proposal of a new prognostic model for hepatocellular carcinoma: an analysis of 403 patients. Gut (2005) 1.54
Clinical utility of anti-signal recognition particle antibody in the differential diagnosis of myopathies. Rheumatology (Oxford) (2008) 1.53
Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy. Rheumatology (Oxford) (2006) 1.53
Mapping of new Escherichia coli K and 15 restriction sites on specific fragments of bacteriophage phi X174. J Virol (1973) 1.52
Increase in plasma thrombomodulin in patients with systemic sclerosis. J Rheumatol (1993) 1.52