Published in Biol Sex Differ on November 09, 2015
An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome. Sci Rep (2016) 0.79
A Comprehensive Diverse '-omics' Approach to Better Understanding the Molecular Pathomechanisms of Down Syndrome. Brain Sci (2017) 0.75
Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice. BMC Neurosci (2017) 0.75
Global quantification of mammalian gene expression control. Nature (2011) 22.36
X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature (2005) 12.06
Policy: NIH to balance sex in cell and animal studies. Nature (2014) 9.15
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat Rev Genet (2012) 8.55
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Preclinical research: Make mouse studies work. Nature (2014) 4.82
The epidemiology of mental retardation: challenges and opportunities in the new millennium. Ment Retard Dev Disabil Res Rev (2002) 3.26
X-linked mental retardation. Nat Rev Genet (2005) 3.10
Global survey of escape from X inactivation by RNA-sequencing in mouse. Genome Res (2010) 2.87
Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation. J Biol Chem (2000) 2.78
Molecular and comparative genetics of mental retardation. Genetics (2004) 2.38
Improved national prevalence estimates for 18 selected major birth defects--United States, 1999-2001. MMWR Morb Mortal Wkly Rep (2006) 2.33
Sex differences in molecular neuroscience: from fruit flies to humans. Nat Rev Neurosci (2010) 2.17
The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging. Neuron (2013) 2.03
Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum Mol Genet (2000) 1.96
Editing modifies the GABA(A) receptor subunit alpha3. RNA (2007) 1.96
Sexual dimorphism in mammalian autosomal gene regulation is determined not only by Sry but by sex chromosome complement as well. Dev Cell (2010) 1.89
Behavioral phenotype of individuals with Down syndrome. Ment Retard Dev Disabil Res Rev (2000) 1.88
Sex differences in the brain: the not so inconvenient truth. J Neurosci (2012) 1.83
The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction. Nat Commun (2014) 1.66
Down's syndrome: a genetic disorder in biobehavioral perspective. Genes Brain Behav (2003) 1.65
Genes that escape from X inactivation. Hum Genet (2011) 1.63
Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving. Mol Biol Evol (2013) 1.61
Down syndrome: MR quantification of brain structures and comparison with normal control subjects. AJNR Am J Neuroradiol (1992) 1.50
X-linked genes and mental functioning. Hum Mol Genet (2005) 1.46
A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet (2010) 1.42
Sex does matter: comments on the prevalence of male-only investigations of drug effects on rodent behaviour. Behav Pharmacol (2007) 1.38
Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J Biol Chem (2002) 1.36
X chromosome regulation: diverse patterns in development, tissues and disease. Nat Rev Genet (2014) 1.36
Down syndrome: cognitive phenotype. Ment Retard Dev Disabil Res Rev (2007) 1.33
Sex differences in the brain, behavior, and neuropsychiatric disorders. Neuroscientist (2010) 1.26
Why women have more Alzheimer's disease than men: gender and mitochondrial toxicity of amyloid-beta peptide. J Alzheimers Dis (2010) 1.20
It is not all hormones: alternative explanations for sexual differentiation of the brain. Brain Res (2006) 1.17
TRP channels as mediators of oxidative stress. Adv Exp Med Biol (2011) 1.17
Development and validation of the Arizona Cognitive Test Battery for Down syndrome. J Neurodev Disord (2010) 1.15
Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke. J Cereb Blood Flow Metab (2011) 1.15
Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia (2010) 1.15
Widespread sex differences in gene expression and splicing in the adult human brain. Nat Commun (2013) 1.15
Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome. J Neurosci (2010) 1.14
Twenty-year trends in prevalence and survival of Down syndrome. Eur J Hum Genet (2008) 1.10
Escape from X inactivation varies in mouse tissues. PLoS Genet (2015) 1.10
Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions. Mamm Genome (2011) 1.08
Consensus paper: Language and the cerebellum: an ongoing enigma. Cerebellum (2014) 1.07
Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. J Biol Chem (2011) 1.05
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res (2010) 1.05
Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome. Brain Pathol (2010) 1.03
Editing of neurotransmitter receptor and ion channel RNAs in the nervous system. Curr Top Microbiol Immunol (2012) 1.01
The prefrontal cortex communicates with the amygdala to impair learning after acute stress in females but not in males. J Neurosci (2010) 1.01
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. Neural Plast (2012) 1.00
Sex differences in the human brain and the impact of sex chromosomes and sex hormones. Cereb Cortex (2012) 0.99
Neurological phenotypes for Down syndrome across the life span. Prog Brain Res (2012) 0.98
Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women. Br J Pharmacol (2014) 0.96
Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging (2011) 0.95
PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor. J Steroid Biochem Mol Biol (2007) 0.94
Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations. Drug Des Devel Ther (2014) 0.93
The roles of phospholipase C activation and alternative ADAR1 and ADAR2 pre-mRNA splicing in modulating serotonin 2C-receptor editing in vivo. RNA (2010) 0.92
TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death. Neurosci Lett (2012) 0.92
SUMO-3 enhances androgen receptor transcriptional activity through a sumoylation-independent mechanism in prostate cancer cells. J Biol Chem (2005) 0.91
A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials. Front Psychol (2015) 0.91
RNA editing as a therapeutic target for CNS disorders. Neuropsychopharmacology (2009) 0.90
Molecular background of progressive myoclonus epilepsy. EMBO J (2003) 0.89
Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats. Neuropharmacology (2013) 0.88
NMDA receptor-deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities. Genes Brain Behav (2014) 0.87
Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome. J Proteome Res (2012) 0.87
Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury. J Cereb Blood Flow Metab (2013) 0.87
Comparative survival advantage of males with Down syndrome. Am J Hum Biol (2003) 0.87
Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: Possible involvement of TRPM2 channels. Metab Brain Dis (2014) 0.85
Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome. Neurobiol Dis (2013) 0.85
Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Mol Brain (2011) 0.84
Pathways to cognitive deficits in Down syndrome. Prog Brain Res (2012) 0.84
Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease. Brain Pathol (2013) 0.84
Hippocampal learning, memory, and neurogenesis: Effects of sex and estrogens across the lifespan in adults. Horm Behav (2015) 0.84
Target-derived matricryptins organize cerebellar synapse formation through α3β1 integrins. Cell Rep (2012) 0.84
Sex chromosome complement regulates expression of mood-related genes. Biol Sex Differ (2013) 0.83
Sex differences in performance over 7 years on the Wechsler Intelligence Scale for Children--Revised among adults with intellectual disability. J Intellect Disabil Res (2004) 0.83
Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ? Biofactors (2011) 0.82
Abnormal microglial activation in the Cstb(-/-) mouse, a model for progressive myoclonus epilepsy, EPM1. Glia (2014) 0.82
Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Hum Mol Genet (2013) 0.82
Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice. Neurobiol Dis (2014) 0.80
Gender specific requirement of GluR1 receptors in contextual conditioning but not spatial learning. Neurobiol Learn Mem (2011) 0.80
Fluoxetine signature on hippocampal MAPK signalling in sex-dependent manner. J Mol Neurosci (2014) 0.79
Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome. Genes Brain Behav (2006) 0.79
Female CREBalphadelta- deficient mice show earlier age-related cognitive deficits than males. Neuroscience (2007) 0.78
Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome. PLoS One (2015) 0.78
Learning and memory: Steroids and epigenetics. J Steroid Biochem Mol Biol (2015) 0.78
Endostatin binds nerve growth factor and thereby inhibits neurite outgrowth and neuronal migration in-vitro. Brain Res (2010) 0.77
Nuclear receptor repression: regulatory mechanisms and physiological implications. Prog Mol Biol Transl Sci (2009) 0.76