Published in Genome Res on July 06, 2006
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One (2010) 7.48
Sex bias in neuroscience and biomedical research. Neurosci Biobehav Rev (2010) 4.39
The sirtuin SIRT6 regulates lifespan in male mice. Nature (2012) 4.07
Sex-specific genetic architecture of human disease. Nat Rev Genet (2008) 4.01
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
Sex-specific and lineage-specific alternative splicing in primates. Genome Res (2009) 3.61
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Dosage compensation is less effective in birds than in mammals. J Biol (2007) 3.04
Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1. Ann Neurol (2014) 3.01
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
Global survey of escape from X inactivation by RNA-sequencing in mouse. Genome Res (2010) 2.87
Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC Syst Biol (2008) 2.51
Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol (2009) 2.45
New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. PLoS Comput Biol (2010) 2.43
Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell (2013) 2.41
Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes. BMC Biol (2007) 2.29
Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A (2008) 2.29
Sex bias in trials and treatment must end. Nature (2010) 2.28
Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori. Genome Biol (2007) 2.21
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A (2007) 2.13
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res (2010) 2.06
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet (2012) 1.97
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. Nat Genet (2008) 1.95
G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. Am J Hypertens (2009) 1.66
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Modular genetic control of sexually dimorphic behaviors. Cell (2012) 1.50
Fast-X on the Z: rapid evolution of sex-linked genes in birds. Genome Res (2007) 1.49
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Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression. Mol Cell Biol (2010) 1.45
Disruption of protein kinase A in mice enhances healthy aging. PLoS One (2009) 1.43
Regulatory divergence in Drosophila melanogaster and D. simulans, a genomewide analysis of allele-specific expression. Genetics (2009) 1.40
Disentangling the relationship between sex-biased gene expression and X-linkage. Genome Res (2012) 1.40
Escape from X inactivation in mice and humans. Genome Biol (2010) 1.39
Fungal Infection Induces Sex-Specific Transcriptional Changes and Alters Sexual Dimorphism in the Dioecious Plant Silene latifolia. PLoS Genet (2015) 1.38
Sex differences in primary hypertension. Biol Sex Differ (2012) 1.37
Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Mol Cell Biol (2011) 1.36
An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. J Bone Miner Res (2009) 1.33
A survey of allelic imbalance in F1 mice. Genome Res (2008) 1.32
Towards a more nuanced understanding of the relationship between sex-biased gene expression and rates of protein-coding sequence evolution. Mol Biol Evol (2011) 1.32
Reporting of sex as a variable in cardiovascular studies using cultured cells. Biol Sex Differ (2011) 1.32
Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver. Mol Endocrinol (2008) 1.30
Sexually dimorphic gene expression in the heart of mice and men. J Mol Med (Berl) (2007) 1.30
Sex-specific splicing in Drosophila: widespread occurrence, tissue specificity and evolutionary conservation. Genetics (2008) 1.30
Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways. PLoS One (2009) 1.28
Gender differences in cancer susceptibility: an inadequately addressed issue. Front Genet (2012) 1.26
Sex specific gene regulation and expression QTLs in mouse macrophages from a strain intercross. PLoS One (2008) 1.24
WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes. Am J Hum Genet (2009) 1.23
The unique genomic properties of sex-biased genes: insights from avian microarray data. BMC Genomics (2008) 1.22
An evolutionarily conserved sexual signature in the primate brain. PLoS Genet (2008) 1.21
Hyperexpression of the X chromosome in both sexes results in extensive female bias of X-linked genes in the flour beetle. Genome Biol Evol (2010) 1.21
Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. Physiol Genomics (2007) 1.20
Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis. Genes Immun (2009) 1.20
Resolving intralocus sexual conflict: genetic mechanisms and time frame. J Hered (2010) 1.19
Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. BMC Genomics (2010) 1.19
Contrasting evolution of expression differences in the testis between species and subspecies of the house mouse. Genome Res (2006) 1.19
Characterization of a newly developed chicken 44K Agilent microarray. BMC Genomics (2008) 1.17
Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. PLoS One (2008) 1.17
Intra- and inter-individual genetic differences in gene expression. Mamm Genome (2009) 1.16
Human and murine kidneys show gender- and species-specific gene expression differences in response to injury. PLoS One (2009) 1.15
Why are sex and gender important to basic physiology and translational and individualized medicine? Am J Physiol Heart Circ Physiol (2014) 1.15
Transitions between male and female heterogamety caused by sex-antagonistic selection. Genetics (2010) 1.13
Sex differences in the human peripheral blood transcriptome. BMC Genomics (2014) 1.13
Representing sex in the brain, one module at a time. Neuron (2014) 1.13
Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5. Mol Endocrinol (2009) 1.12
Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Genome Biol Evol (2010) 1.12
Sex dimorphism and depot differences in adipose tissue function. Biochim Biophys Acta (2013) 1.10
Hypertension: what's sex got to do with it? Physiology (Bethesda) (2013) 1.09
Sex-specific early growth hormone response genes in rat liver. Mol Endocrinol (2008) 1.08
Sex differences in microRNA regulation of gene expression: no smoke, just miRs. Biol Sex Differ (2012) 1.08
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Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome. BMC Genomics (2010) 1.06
A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age. Transl Res (2008) 1.06
Complex genetics of obesity in mouse models. Annu Rev Nutr (2008) 1.06
Sex-biased methylome and transcriptome in human prefrontal cortex. Hum Mol Genet (2013) 1.06
Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. PLoS One (2011) 1.06
Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalence. Sci Signal (2010) 1.05
From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence. Liver Cancer (2013) 1.05
Intrinsic sex differences in the early growth hormone responsiveness of sex-specific genes in mouse liver. Mol Endocrinol (2010) 1.05
The X-chromosome has a different pattern of gene expression in women compared with men with ischemic stroke. Stroke (2011) 1.05
Sex-biased genetic effects on gene regulation in humans. Genome Res (2012) 1.05
Evolution of sex-dependent gene expression in three recently diverged species of Drosophila. Genetics (2009) 1.04
The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism. J Biol Chem (2009) 1.04
The sex-biased brain: sexual dimorphism in gene expression in two species of songbirds. BMC Genomics (2011) 1.04
Systematic analysis of emotionality in consomic mouse strains established from C57BL/6J and wild-derived MSM/Ms. Genes Brain Behav (2008) 1.02
Identification and validation of genes affecting aortic lesions in mice. J Clin Invest (2010) 1.02
Sex differences in metabolic homeostasis, diabetes, and obesity. Biol Sex Differ (2015) 1.01
Integrating global gene expression analysis and genetics. Adv Genet (2008) 1.01
Sex/gender medicine. The biological basis for personalized care in cardiovascular medicine. Circ J (2009) 1.01
Modeling cognitive dysfunction in neurofibromatosis-1. Trends Neurosci (2013) 1.00
Masculinization of gene expression is associated with exaggeration of male sexual dimorphism. PLoS Genet (2013) 1.00
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Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
An abundance of X-linked genes expressed in spermatogonia. Nat Genet (2001) 5.87
Strategies and methods for research on sex differences in brain and behavior. Endocrinology (2004) 5.02
Rosetta error model for gene expression analysis. Bioinformatics (2006) 4.67
The mouse X chromosome is enriched for sex-biased genes not subject to selection by meiotic sex chromosome inactivation. Nat Genet (2004) 4.62
oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes. Nucleic Acids Res (2005) 4.52
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics (2003) 3.33
A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci (2002) 3.09
Evidence of a large-scale functional organization of mammalian chromosomes. PLoS Genet (2005) 2.73
Major molecular differences between mammalian sexes are involved in drug metabolism and renal function. Dev Cell (2004) 2.65
Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes. Neuropsychopharmacology (2004) 2.48
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Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol (2006) 2.17
Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Brain Res Mol Brain Res (2003) 1.93
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Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Genes Dev (2003) 1.32
Role of hepatocyte nuclear factors in growth hormone-regulated, sexually dimorphic expression of liver cytochromes P450. Growth Factors (2004) 1.29
TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci (2001) 1.24
Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain. Gene Expr Patterns (2005) 1.17
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Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice. Biochem Biophys Res Commun (2005) 1.15
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Lactogenic hormone regulation of maternal behavior. Prog Brain Res (2001) 1.07
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Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
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Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
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The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
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Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
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Nova regulates brain-specific splicing to shape the synapse. Nat Genet (2005) 6.58
The genome of a songbird. Nature (2010) 5.90
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
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Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol (2007) 5.53
Strategies and methods for research on sex differences in brain and behavior. Endocrinology (2004) 5.02
Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63
Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends Genet (2005) 4.56
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A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
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Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
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Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41
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Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. PLoS Comput Biol (2007) 3.37
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Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res (2008) 3.26
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15
Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science (2002) 3.13
A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci (2002) 3.09
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Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes (2008) 3.05
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab (2013) 3.01
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res (2011) 3.00
Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
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