Published in Adv Drug Deliv Rev on October 24, 2015
Platelet-mimetic strategies for modulating the wound environment and inflammatory responses. Exp Biol Med (Maywood) (2016) 0.77
Effects of the Microparticle Shape on Cellular Uptake. Mol Pharm (2016) 0.77
Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol (2007) 17.80
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res (1986) 15.83
Renal clearance of quantum dots. Nat Biotechnol (2007) 12.54
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci U S A (2003) 12.17
Drug delivery systems: entering the mainstream. Science (2004) 9.27
Monocyte recruitment during infection and inflammation. Nat Rev Immunol (2011) 7.55
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm (2005) 7.53
Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov (2010) 7.48
The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A (2008) 7.06
Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J (2004) 6.90
Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol (2007) 6.85
Role of target geometry in phagocytosis. Proc Natl Acad Sci U S A (2006) 6.62
Direct observation of catch bonds involving cell-adhesion molecules. Nature (2003) 6.30
Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer (2006) 5.75
Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett (2007) 5.48
Nanomedicine: current status and future prospects. FASEB J (2005) 4.28
Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials. J Am Chem Soc (2005) 4.02
Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol Rev (1999) 4.02
Physical approaches to biomaterial design. Nat Mater (2009) 4.01
Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog Lipid Res (2003) 3.89
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Deliv Rev (2008) 3.80
Mechanics of receptor-mediated endocytosis. Proc Natl Acad Sci U S A (2005) 3.78
Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol (2008) 3.78
Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials (2008) 3.68
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood (2004) 3.59
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol (2007) 3.54
Endocytosis via caveolae. Traffic (2002) 3.41
The structure and function of the endothelial glycocalyx layer. Annu Rev Biomed Eng (2007) 3.40
Scanning probe-based frequency-dependent microrheology of polymer gels and biological cells. Phys Rev Lett (2000) 3.34
Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science (2012) 3.33
The hydrodynamically relevant endothelial cell glycocalyx observed in vivo is absent in vitro. Circ Res (2008) 3.17
Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release (2009) 3.08
Mechanotransduction and flow across the endothelial glycocalyx. Proc Natl Acad Sci U S A (2003) 2.93
Adhesion mechanisms regulating the migration of monocytes. Nat Rev Immunol (2004) 2.81
Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers. J Control Release (2007) 2.74
The adhesive strength of non-spherical particles mediated by specific interactions. Biomaterials (2006) 2.71
Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Mol Ther (2008) 2.69
Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles. Proc Natl Acad Sci U S A (2011) 2.63
Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target. J Cell Sci (2002) 2.54
A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1. J Cell Sci (2003) 2.34
Nanoparticle biointerfacing by platelet membrane cloaking. Nature (2015) 2.09
Flow-enhanced adhesion regulated by a selectin interdomain hinge. J Cell Biol (2006) 2.02
A theoretical model for the margination of particles within blood vessels. Ann Biomed Eng (2005) 1.97
Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. J Control Release (2012) 1.95
Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev (2007) 1.94
Shape induced inhibition of phagocytosis of polymer particles. Pharm Res (2008) 1.91
Size of IgG-opsonized particles determines macrophage response during internalization. Exp Cell Res (1998) 1.91
Imparting size, shape, and composition control of materials for nanomedicine. Chem Soc Rev (2006) 1.91
Multiparticle adhesive dynamics: hydrodynamic recruitment of rolling leukocytes. Proc Natl Acad Sci U S A (2001) 1.86
Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS. J Immunol (2009) 1.85
Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim Biophys Acta (1994) 1.79
Influence of hemodynamic forces on vascular endothelial function. In vitro studies of shear stress and pinocytosis in bovine aortic cells. J Clin Invest (1984) 1.77
Mechanics of neutrophil phagocytosis: experiments and quantitative models. J Cell Sci (2006) 1.75
Optical tweezers for single cells. J R Soc Interface (2008) 1.74
Mechanics and contraction dynamics of single platelets and implications for clot stiffening. Nat Mater (2010) 1.73
Folate-targeted therapies for cancer. J Med Chem (2010) 1.73
Shear stress and the endothelial transport barrier. Cardiovasc Res (2010) 1.72
Design maps for nanoparticles targeting the diseased microvasculature. Biomaterials (2007) 1.72
The receptor-mediated endocytosis of nonspherical particles. Biophys J (2008) 1.68
Role of glycocalyx in leukocyte-endothelial cell adhesion. Am J Physiol Heart Circ Physiol (2002) 1.66
Inflammation- and ischemia-induced shedding of venular glycocalyx. Am J Physiol Heart Circ Physiol (2004) 1.63
The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles. Biomaterials (2007) 1.60
Advanced drug delivery systems that target the vascular endothelium. Mol Interv (2006) 1.54
Targeting of antioxidant and anti-thrombotic drugs to endothelial cell adhesion molecules. Curr Pharm Des (2005) 1.53
Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments. Proc Natl Acad Sci U S A (2010) 1.53
Molecular determinants of endothelial transcytosis and their role in endothelial permeability. Am J Physiol Lung Cell Mol Physiol (2007) 1.53
Development of ligand-targeted liposomes for cancer therapy. Expert Opin Ther Targets (2004) 1.48
Heparinase treatment suggests a role for the endothelial cell glycocalyx in regulation of capillary hematocrit. Am J Physiol (1990) 1.47
Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular immunotargeting of drugs. Proc Natl Acad Sci U S A (1999) 1.46
Molecular imaging and therapy of atherosclerosis with targeted nanoparticles. J Magn Reson Imaging (2007) 1.46
The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows. J Biomech (2008) 1.46
Transport governs flow-enhanced cell tethering through L-selectin at threshold shear. Biophys J (2006) 1.45
Computer simulation of the translocation of nanoparticles with different shapes across a lipid bilayer. Nat Nanotechnol (2010) 1.45
Targeted worm micelles. Biomacromolecules (2004) 1.45
Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small (2009) 1.41
Potential role of size and hemodynamics in the efficacy of vascular-targeted spherical drug carriers. Biomaterials (2009) 1.40
Red blood cell-mimicking synthetic biomaterial particles. Proc Natl Acad Sci U S A (2009) 1.38
Micelles of different morphologies--advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharm Res (2007) 1.38
Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium. Proc Natl Acad Sci U S A (2013) 1.37
On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better. Sci Rep (2013) 1.35
Flow and adhesion of drug carriers in blood vessels depend on their shape: a study using model synthetic microvascular networks. J Control Release (2010) 1.35
Cell-mediated drug delivery. Expert Opin Drug Deliv (2011) 1.33
Flow dynamics, binding and detachment of spherical carriers targeted to ICAM-1 on endothelial cells. Biorheology (2009) 1.32
Red blood cells augment leukocyte rolling in a virtual blood vessel. Biophys J (2002) 1.31
Drug delivery by red blood cells: vascular carriers designed by mother nature. Expert Opin Drug Deliv (2010) 1.30
Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells. Blood (2002) 1.30
Intravenous hemostat: nanotechnology to halt bleeding. Sci Transl Med (2009) 1.29
Endothelial endocytic pathways: gates for vascular drug delivery. Curr Vasc Pharmacol (2004) 1.25
Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows. Microvasc Res (2009) 1.24
Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity. Cancer Res (1989) 1.19
Targeted drug delivery and penetration into solid tumors. Med Res Rev (2011) 1.19
Design of bio-mimetic particles with enhanced vascular interaction. J Biomech (2009) 1.15
Modeling particle shape-dependent dynamics in nanomedicine. J Nanosci Nanotechnol (2011) 1.14
The influence of size, shape and vessel geometry on nanoparticle distribution. Microfluid Nanofluidics (2012) 1.13
Multivalent binding of nanocarrier to endothelial cells under shear flow. Biophys J (2011) 1.13
SyM-BBB: a microfluidic Blood Brain Barrier model. Lab Chip (2013) 1.12
Macrophage delivery of therapeutic nanozymes in a murine model of Parkinson's disease. Nanomedicine (Lond) (2010) 1.12
Human complement receptor type 1-directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis. Blood (2006) 1.11
Liposomes: the development of a new carrier system for introducing nucleic acid into plant and animal cells. Curr Top Microbiol Immunol (1982) 1.11
Targeted delivery of therapeutics to endothelium. Cell Tissue Res (2008) 1.10