Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular immunotargeting of drugs.

PubWeight™: 1.46‹?› | Rank: Top 5%

🔗 View Article (PMC 26792)

Published in Proc Natl Acad Sci U S A on March 02, 1999

Authors

V R Muzykantov1, M Christofidou-Solomidou, I Balyasnikova, D W Harshaw, L Schultz, A B Fisher, S M Albelda

Author Affiliations

1: Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA, 19104-60608, USA. muzykant@mail.med.upenn.edu

Articles citing this

Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol (2007) 3.54

Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities. Science (2012) 2.73

Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: a pathway to overcome cell barriers to drug and gene delivery. Proc Natl Acad Sci U S A (2002) 1.43

Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies. Biomaterials (2007) 1.17

A semiempirical model of tumor pretargeting. Bioconjug Chem (2008) 1.16

Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature. Blood (2005) 1.15

Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature. Blood (2007) 1.14

RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1. Blood (2008) 1.13

Targeted detoxification of selected reactive oxygen species in the vascular endothelium. J Pharmacol Exp Ther (2009) 1.11

PECAM-targeted delivery of SOD inhibits endothelial inflammatory response. FASEB J (2010) 1.11

Targeted delivery of therapeutics to endothelium. Cell Tissue Res (2008) 1.10

Catalase and superoxide dismutase conjugated with platelet-endothelial cell adhesion molecule antibody distinctly alleviate abnormal endothelial permeability caused by exogenous reactive oxygen species and vascular endothelial growth factor. J Pharmacol Exp Ther (2011) 1.07

Nanocarriers for vascular delivery of antioxidants. Nanomedicine (Lond) (2011) 1.06

Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes. J Control Release (2008) 1.06

Endothelial targeting of antibody-decorated polymeric filomicelles. ACS Nano (2011) 1.03

Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation. Am J Respir Crit Care Med (2009) 1.03

Imaging molecular expression on vascular endothelial cells by in vivo immunofluorescence microscopy. Mol Imaging (2006) 1.02

Acute and chronic shear stress differently regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1. ACS Nano (2012) 1.02

An experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effector. Mol Cancer Ther (2008) 1.01

Targeted modulation of reactive oxygen species in the vascular endothelium. J Control Release (2011) 0.97

Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo. J Control Release (2012) 0.94

Advanced drug delivery systems for antithrombotic agents. Blood (2013) 0.92

Vascular immunotargeting of glucose oxidase to the endothelial antigens induces distinct forms of oxidant acute lung injury: targeting to thrombomodulin, but not to PECAM-1, causes pulmonary thrombosis and neutrophil transmigration. Am J Pathol (2002) 0.92

Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm. ACS Nano (2014) 0.92

Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124. Biomaterials (2012) 0.89

Modulation of endothelial targeting by size of antibody-antioxidant enzyme conjugates. J Control Release (2010) 0.88

Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo. PLoS One (2013) 0.87

Factors modulating the delivery and effect of enzymatic cargo conjugated with antibodies targeted to the pulmonary endothelium. J Control Release (2007) 0.87

Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism. J Nanobiotechnology (2012) 0.86

Icam-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation. PLoS One (2014) 0.86

PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesis. Clin Sci (Lond) (2015) 0.85

Interaction between drug delivery vehicles and cells under the effect of shear stress. Biomicrofluidics (2015) 0.83

Targeting antioxidant and antithrombotic biotherapeutics to endothelium. Semin Thromb Hemost (2010) 0.83

Targeting prostate cancer cells with a multivalent PSMA inhibitor-guided streptavidin conjugate. Bioorg Med Chem Lett (2012) 0.81

SHP-2 phosphatase activity is required for PECAM-1-dependent cell motility. Am J Physiol Cell Physiol (2010) 0.81

Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation. J Control Release (2014) 0.81

Targeted delivery of nucleic-acid-based therapeutics to the pulmonary circulation. AAPS J (2009) 0.80

Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Control Release (2015) 0.79

Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS Nano (2015) 0.79

Vascular targeting of antithrombotic agents. IUBMB Life (2011) 0.78

Non-affinity factors modulating vascular targeting of nano- and microcarriers. Adv Drug Deliv Rev (2015) 0.78

Targeted endothelial nanomedicine for common acute pathological conditions. J Control Release (2015) 0.77

Targeting to endothelial cells augments the protective effect of novel dual bioactive antioxidant/anti-inflammatory nanoparticles. Mol Pharm (2014) 0.77

Chemically self-assembled antibody nanostructures as potential drug carriers. Mol Pharm (2012) 0.77

Influence of PECAM-1 ligand interactions on PECAM-1-dependent cell motility and filopodia extension. Physiol Rep (2016) 0.75

Targeting delivery of drugs in the vascular system. Int J Transp Phenom (2011) 0.75

Articles cited by this

Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci U S A (1983) 7.55

Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol (1991) 3.91

The avidin-biotin complex in bioanalytical applications. Anal Biochem (1988) 3.17

Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science (1993) 2.71

Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol (1997) 2.17

The biology of PECAM-1. J Clin Invest (1997) 2.01

Investigations of avidin and biotin for imaging applications. J Nucl Med (1987) 1.88

Localization of multiple functional domains on human PECAM-1 (CD31) by monoclonal antibody epitope mapping. Cell Adhes Commun (1995) 1.27

Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system. Proc Natl Acad Sci U S A (1997) 1.14

Vascular targeting--a new approach to the therapy of solid tumors. Pharmacol Ther (1994) 1.08

Apical topography and modulation of ICAM-1 expression on activated endothelium. Am J Pathol (1995) 1.05

Immunotargeting of antioxidant enzyme to the pulmonary endothelium. Proc Natl Acad Sci U S A (1996) 1.03

Lipid composition is important for highly efficient target binding and retention of immunoliposomes. Proc Natl Acad Sci U S A (1990) 1.02

Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release. J Clin Invest (1998) 1.01

Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery. Proc Natl Acad Sci U S A (1993) 1.01

Two-step tumour targetting in ovarian cancer patients using biotinylated monoclonal antibodies and radioactive streptavidin. Eur J Nucl Med (1992) 1.00

Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress. Am J Physiol (1998) 0.97

Blood clearance of radiolabeled antibody: enhancement by lactosamination and treatment with biotin-avidin or anti-mouse IgG antibodies. J Nucl Med (1988) 0.92

Endothelial cells internalize monoclonal antibody to angiotensin-converting enzyme. Am J Physiol (1996) 0.90

Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme. J Nucl Med (1991) 0.88

Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme. Lab Invest (1991) 0.84

Adult respiratory distress syndrome: a radical perspective. Adv Pharmacol (1997) 0.82

The functional effects of biotinylation of anti-angiotensin-converting enzyme monoclonal antibody in terms of targeting in vivo. Anal Biochem (1995) 0.81

Epitope-dependent selective targeting of thrombomodulin monoclonal antibodies to either surface or intracellular compartment of endothelial cells. Drug Deliv (1998) 0.80

Articles by these authors

Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nat Med (2000) 4.36

Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med (1995) 3.88

Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J Cell Biol (1993) 3.74

Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes. J Nucl Med (2001) 3.24

Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan. J Neurooncol (2008) 2.97

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development (1994) 2.71

Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science (1993) 2.71

Pneumococcal polysaccharide immunization in infants and children. Pediatrics (1978) 2.67

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58

CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion. J Exp Med (1992) 2.38

Psychiatric sequelae of posttraumatic stress disorder in women. Arch Gen Psychiatry (1997) 2.29

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem (2000) 2.20

Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol (1997) 2.17

Molecular and functional aspects of PECAM-1/CD31. Immunol Today (1994) 2.04

1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. J Biol Chem (2000) 2.00

Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype. J Investig Dermatol Symp Proc (1999) 1.96

Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala. Ann Neurol (1992) 1.95

Effects of propranolol in non-Q-wave acute myocardial infarction in the beta blocker heart attack trial. Am J Cardiol (1990) 1.94

Metabolic imaging of malignant pleural mesothelioma with fluorodeoxyglucose positron emission tomography. Chest (1998) 1.91

Corticotropin-releasing hormone is a rapid and potent convulsant in the infant rat. Brain Res Dev Brain Res (1991) 1.90

Successful adenovirus-mediated gene transfer in an in vivo model of human malignant mesothelioma. Ann Thorac Surg (1994) 1.89

Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST. Proc Natl Acad Sci U S A (2004) 1.88

Sex differences in depression: a role for preexisting anxiety. Psychiatry Res (1995) 1.76

Pilot trial of IOM duty hour recommendations in neurology residency programs: unintended consequences. Neurology (2011) 1.69

Prognostic value of FDG PET imaging in malignant pleural mesothelioma. J Nucl Med (1999) 1.67

Adaptive modulations of martensites. Phys Rev Lett (2010) 1.62

Febrile seizures: an appropriate-aged model suitable for long-term studies. Brain Res Dev Brain Res (1997) 1.60

The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells. Stem Cells (2001) 1.59

Education research: Bias and poor interrater reliability in evaluating the neurology clinical skills examination. Neurology (2009) 1.58

An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane. J Exp Med (1996) 1.58

Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates beta 2 integrins on lymphokine-activated killer cells. Eur J Immunol (1993) 1.58

Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. J Biol Chem (1993) 1.55

T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. J Exp Med (1994) 1.55

A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31). J Exp Med (1992) 1.55

Fracture mechanisms in bulk metallic glassy materials. Phys Rev Lett (2003) 1.52

Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma. Hum Gene Ther (1998) 1.51

Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+. Circ Res (1998) 1.50

Development of an integrated laboratory information management system for the maize mapping project. Bioinformatics (2003) 1.50

Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity. J Biol Chem (1996) 1.50

Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. J Clin Invest (1992) 1.48

Granular pneumocytes in primary culture secrete several major components of the extracellular matrix. Biochemistry (1983) 1.47

Experimental aspects of peripheral vascular occlusion of the intestine. Surg Gynecol Obstet (1965) 1.45

Corticotropin-releasing hormone (CRH)-containing neurons in the immature rat hippocampal formation: light and electron microscopic features and colocalization with glutamate decarboxylase and parvalbumin. Hippocampus (1998) 1.42

Human/severe combined immunodeficient mouse chimeras. An experimental in vivo model system to study the regulation of human endothelial cell-leukocyte adhesion molecules. J Clin Invest (1993) 1.42

Loss of endothelial surface expression of E-selectin in a patient with recurrent infections. Blood (1999) 1.42

Cloning and expression of rat lung acidic Ca(2+)-independent PLA2 and its organ distribution. Am J Physiol (1998) 1.41

Mechanism for the potentiation of oxygen toxicity by disulfiram. J Pharmacol Exp Ther (1980) 1.40

Growth and invasion of human melanomas in human skin grafted to immunodeficient mice. Am J Pathol (1993) 1.39

Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression. J Biol Chem (1996) 1.37

Distribution of integrin cell adhesion receptors on normal bronchial epithelial cells and lung cancer cells in vitro and in vivo. Am J Respir Cell Mol Biol (1993) 1.37

Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events. J Cell Biol (1990) 1.32

Distribution of integrin cell adhesion receptors in normal and malignant lung tissue. Am J Respir Cell Mol Biol (1992) 1.31

Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol Biol Cell (1993) 1.31

KATP channels are an important component of the shear-sensing mechanism in the pulmonary microvasculature. Microcirculation (2006) 1.30

Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation. Am J Pathol (1992) 1.30

Abnormal corticosterone regulation in an immature rat model of continuous chronic stress. Pediatr Neurol (1996) 1.30

Antibodies against the first Ig-like domain of human platelet endothelial cell adhesion molecule-1 (PECAM-1) that inhibit PECAM-1-dependent homophilic adhesion block in vivo neutrophil recruitment. J Immunol (2000) 1.29

Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma. Hum Gene Ther (1998) 1.29

Involvement of annexin II in exocytosis of lamellar bodies from alveolar epithelial type II cells. Am J Physiol (1996) 1.29

Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo. Am J Pathol (1993) 1.28

Localization of multiple functional domains on human PECAM-1 (CD31) by monoclonal antibody epitope mapping. Cell Adhes Commun (1995) 1.27

Are smokers with alcohol disorders less likely to quit? Am J Public Health (1996) 1.25

Lung lamellar bodies maintain an acidic internal pH. J Biol Chem (1986) 1.23

Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) result in changes in ligand binding properties. J Cell Biol (1994) 1.23

Platelet endothelial cell adhesion molecule, PECAM-1, modulates cell migration. J Cell Physiol (1992) 1.22

Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. J Biol Chem (1998) 1.21

Diagnostic utility of pleural fluid eosinophilia. Am J Med (1984) 1.20

Evaluation of the forced oscillation technique for the determination of resistance to breathing. J Clin Invest (1968) 1.20

Reactive species in ischemic rat lung injury: contribution of peroxynitrite. Am J Physiol (1995) 1.19

Tuberculous pleural effusions. Chest (1987) 1.19

Strain-induced insulator state and giant gauge factor of La0.7Sr0.3CoO3 films. Phys Rev Lett (2008) 1.18

Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting. Am J Physiol Lung Cell Mol Physiol (2001) 1.18

Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling. Circ Res (1999) 1.18

Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity. Cancer Res (2001) 1.17

Perioperative allogeneic blood transfusions. Survival in patients with resected carcinomas of the colon and rectum. Arch Surg (1985) 1.17

Protein disulfide isomerase is essential for viability in Saccharomyces cerevisiae. Gene (1991) 1.16

B cells are not essential for peripheral T-cell tolerance. Proc Natl Acad Sci U S A (1996) 1.15

Alternative splicing of a specific cytoplasmic exon alters the binding characteristics of murine platelet/endothelial cell adhesion molecule-1 (PECAM-1). J Biol Chem (1995) 1.15

Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells. J Exp Med (1986) 1.14

Adhesion molecules in the lung. An overview. Am Rev Respir Dis (1993) 1.13

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis. Oncogene (2012) 1.13

Advances in the treatment of malignant pleural mesothelioma. Chest (1999) 1.11

Use of carrier cells to deliver a replication-selective herpes simplex virus-1 mutant for the intraperitoneal therapy of epithelial ovarian cancer. Clin Cancer Res (1999) 1.11

Generation and characterization of monoclonal antibodies to alveolar type II cell lamellar body membrane. Am J Physiol (1998) 1.11

Regulation of lung surfactant secretion. Am J Physiol (1990) 1.10

Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice. Angiogenesis (1999) 1.10

Changes in plasma gelsolin concentration during acute oxidant lung injury in mice. Lung (2002) 1.09

Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system. Cancer Res (1994) 1.09

Contributions of the extracellular and cytoplasmic domains of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in regulating cell-cell localization. J Cell Sci (2000) 1.09

High upper critical fields and evidence of weak-link behavior in superconducting LaFeAsO1-xFx thin films. Phys Rev Lett (2010) 1.09

Localization, synthesis, and processing of surfactant protein SP-C in rat lung analyzed by epitope-specific antipeptide antibodies. J Biol Chem (1994) 1.09

Reasons for early recurrence following laparoscopic hernioplasty. Surg Endosc (1995) 1.08

Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein. J Biol Chem (1997) 1.08

Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo. Am J Physiol (1997) 1.08

Cytoplasmic and transmembrane domains of integrin beta 1 and beta 3 subunits are functionally interchangeable. J Cell Biol (1991) 1.08

An ethanol/ether soluble apoprotein from rat lung surfactant augments liposome uptake by isolated granular pneumocytes. J Clin Invest (1984) 1.07

Anticancer activity of botanical compounds in ancient fermented beverages (review). Int J Oncol (2010) 1.07

Platelet endothelial cell adhesion molecule (CD31). Curr Top Microbiol Immunol (1993) 1.07