Published in J Nanosci Nanotechnol on December 01, 2015
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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res (2004) 21.36
Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71
Global burden of childhood pneumonia and diarrhoea. Lancet (2013) 9.28
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res (2004) 5.57
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30
ESPRIT: estimating species richness using large collections of 16S rRNA pyrosequences. Nucleic Acids Res (2009) 4.93
Maternal deaths averted by contraceptive use: an analysis of 172 countries. Lancet (2012) 4.65
Plants and people from the Early Neolithic to Shang periods in North China. Proc Natl Acad Sci U S A (2007) 4.30
Distinct memory traces for two visual features in the Drosophila brain. Nature (2006) 3.48
Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev (2007) 3.46
Complete genome sequence of citrus huanglongbing bacterium, 'Candidatus Liberibacter asiaticus' obtained through metagenomics. Mol Plant Microbe Interact (2009) 3.33
Evolutionary diagnosis method for variants in personal exomes. Nat Methods (2012) 3.32
Epidemiology and etiology of childhood pneumonia in 2010: estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries. J Glob Health (2013) 3.30
Hormones and menopausal status as predictors of depression in women in transition to menopause. Arch Gen Psychiatry (2004) 3.13
Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990-2010: a systematic review and analysis. Lancet (2013) 3.02
Ending of preventable deaths from pneumonia and diarrhoea: an achievable goal. Lancet (2013) 2.98
Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell (2013) 2.94
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci (2007) 2.68
Neuronal transcriptome of Aplysia: neuronal compartments and circuitry. Cell (2006) 2.61
Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders. Neuron (2013) 2.45
Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med (2006) 2.37
BCR-ABL alternative splicing as a common mechanism for imatinib resistance: evidence from molecular dynamics simulations. Mol Cancer Ther (2008) 2.31
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron (2004) 2.29
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther (2012) 2.21
Ultraflat graphene. Nature (2009) 2.16
A dynamic gene expression atlas covering the entire life cycle of rice. Plant J (2009) 2.15
Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis. Brain (2012) 2.15
Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res Clin Pract (2013) 2.12
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J (2008) 2.08
Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology (2009) 2.05
Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. J Biol Chem (2009) 2.02
The aftermath of hip fracture: discharge placement, functional status change, and mortality. Am J Epidemiol (2009) 2.02
Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD. Gut (2012) 2.00
Neural synchronization during face-to-face communication. J Neurosci (2012) 1.99
Hospital episodes and physician visits: the concordance between self-reports and medicare claims. Med Care (2007) 1.96
Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. Immunogenetics (2005) 1.95
A treatment-resistant default mode subnetwork in major depression. Biol Psychiatry (2012) 1.94
Improved breast cancer prognosis through the combination of clinical and genetic markers. Bioinformatics (2006) 1.93
Activation of telomerase by human cytomegalovirus. J Natl Cancer Inst (2009) 1.92
Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells. Am J Gastroenterol (2007) 1.92
The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med (2011) 1.88
GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet (2012) 1.86
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development (2005) 1.85
A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc Natl Acad Sci U S A (2010) 1.85
MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res (2011) 1.80
Etiology and clinical characteristics of membranous nephropathy in Chinese patients. Am J Kidney Dis (2008) 1.80
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem (2012) 1.79
Nucleoside analogue can improve the long-term prognosis of patients with hepatitis B virus infection-associated acute on chronic liver failure. Dig Dis Sci (2010) 1.78
A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science (2012) 1.78
Identification of open reading frames unique to a select agent: Ralstonia solanacearum race 3 biovar 2. Mol Plant Microbe Interact (2006) 1.77
Onset of breast and pubic hair development and menses in urban chinese girls. Pediatrics (2009) 1.76
HIV/STD prevalence among men who have sex with men in Chengdu, China and associated risk factors for HIV infection. J Acquir Immune Defic Syndr (2010) 1.76
Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa. Mol Ther (2010) 1.75
Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology (2003) 1.74
Involvement of reductive stress in the cardiomyopathy in transgenic mice with cardiac-specific overexpression of heat shock protein 27. Hypertension (2010) 1.73
Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression. J Immunol (2009) 1.72
A long non-coding RNA signature to improve prognosis prediction of colorectal cancer. Oncotarget (2014) 1.64
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat Genet (2012) 1.64
Prevalence and rates of recognition of depressive disorders in internal medicine outpatient departments of 23 general hospitals in Shenyang, China. J Affect Disord (2008) 1.63
Evidence of the existence of the low-density liquid phase in supercooled, confined water. Proc Natl Acad Sci U S A (2006) 1.62
Atmospheric oxygen binding and hole doping in deformed graphene on a SiO₂ substrate. Nano Lett (2010) 1.62
Expression and purification of recombinant proteins from Escherichia coli: Comparison of an elastin-like polypeptide fusion with an oligohistidine fusion. Protein Sci (2004) 1.62
Toll-like receptor 3 plays a central role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med (2012) 1.61
Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells. Cancer Biol Ther (2006) 1.60
Aqp2-expressing cells give rise to renal intercalated cells. J Am Soc Nephrol (2013) 1.59
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron (2008) 1.59
Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol (2008) 1.59
Screening of patients with tuberculosis for diabetes mellitus in China. Trop Med Int Health (2012) 1.58
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci (2007) 1.58
Hyperactive transposase mutants of the Sleeping Beauty transposon. Mol Ther (2005) 1.58
Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J (2002) 1.58
Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1. Nat Commun (2013) 1.57
Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex. Hepatology (2014) 1.55
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem (2004) 1.55
Predictors of decreased libido in women during the late reproductive years. Menopause (2004) 1.54
Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Proc Natl Acad Sci U S A (2004) 1.54
The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev Cell (2013) 1.54
Development of aliphatic biodegradable photoluminescent polymers. Proc Natl Acad Sci U S A (2009) 1.54
Down-regulated expression of SATB2 is associated with metastasis and poor prognosis in colorectal cancer. J Pathol (2009) 1.53
PVD following plasmin but not hyaluronidase: implications for combination pharmacologic vitreolysis therapy. Retina (2005) 1.52
Meta-analysis of methylcobalamin alone and in combination with prostaglandin E1 in the treatment of diabetic peripheral neuropathy. Endocrine (2014) 1.51
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet (2012) 1.49
Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes. PLoS Genet (2013) 1.48
Supramolecular polymerization promoted and controlled through self-sorting. Angew Chem Int Ed Engl (2014) 1.47
A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Int J Cancer (2010) 1.46
Moscow eye microsurgery complex in Russia keratoprosthesis in Beijing. Ophthalmology (2010) 1.45
Acquired ADAMTS-13 deficiency in pediatric patients with severe sepsis. Haematologica (2007) 1.45
Chemical fingerprinting of Liuwei Dihuang Pill and simultaneous determination of its major bioactive constituents by HPLC coupled with multiple detections of DAD, ELSD and ESI-MS. J Pharm Biomed Anal (2008) 1.45
Dynamic changes of vascular endothelial growth factor and angiopoietin-1 in association with circulating endothelial progenitor cells after severe traumatic brain injury. J Trauma (2011) 1.44
Estimating the distribution of causes of death among children age 1-59 months in high-mortality countries with incomplete death certification. Int J Epidemiol (2010) 1.43
The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. J Virol (2005) 1.43
Role of Cdk4 in lymphocyte function and allergen response. Cell Cycle (2010) 1.43
Distribution, translocation and accumulation of silver nanoparticles in rats. J Nanosci Nanotechnol (2009) 1.43
Akt is a downstream target of NF-kappa B. J Biol Chem (2002) 1.43