Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.

PubWeight™: 1.49‹?› | Rank: Top 4%

🔗 View Article (PMID 22797725)

Published in Nat Genet on July 15, 2012

Authors

Jing Dong1, Zhibin Hu, Chen Wu, Huan Guo, Baosen Zhou, Jiachun Lv, Daru Lu, Kexin Chen, Yongyong Shi, Minjie Chu, Cheng Wang, Ruyang Zhang, Juncheng Dai, Yue Jiang, Songyu Cao, Zhenzhen Qin, Dianke Yu, Hongxia Ma, Guangfu Jin, Jianhang Gong, Chongqi Sun, Xueying Zhao, Zhihua Yin, Lei Yang, Zhiqiang Li, Qifei Deng, Jiucun Wang, Wei Wu, Hong Zheng, Guoquan Zhou, Hongyan Chen, Peng Guan, Zhihang Peng, Yijiang Chen, Yongqian Shu, Lin Xu, Xiangyang Liu, Li Liu, Pin Xu, Baohui Han, Chunxue Bai, Yuxia Zhao, Haibo Zhang, Ying Yan, Christopher I Amos, Feng Chen, Wen Tan, Li Jin, Tangchun Wu, Dongxin Lin, Hongbing Shen

Author Affiliations

1: Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.

Articles citing this

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26

Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet (2012) 1.57

Association of GWAS-identified lung cancer susceptibility loci with survival length in patients with small-cell lung cancer treated with platinum-based chemotherapy. PLoS One (2014) 1.38

EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy. PLoS One (2013) 1.18

Genetic susceptibility to lung cancer and co-morbidities. J Thorac Dis (2013) 1.02

Genetic susceptibility to lung cancer--light at the end of the tunnel? Carcinogenesis (2013) 1.00

Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era. BMC Med (2013) 0.96

Research status and funding trends of lung cancer biomarkers. J Thorac Dis (2013) 0.93

Linking vitamin d deficiency to inflammatory bowel disease. Inflamm Bowel Dis (2013) 0.92

An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D. Mol Diagn Ther (2014) 0.91

Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model. BMC Med Genet (2012) 0.89

A genome-wide gene-gene interaction analysis identifies an epistatic gene pair for lung cancer susceptibility in Han Chinese. Carcinogenesis (2013) 0.88

Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma. BMC Syst Biol (2013) 0.87

The role of haplotype in 15q25.1 locus in lung cancer risk: results of scanning chromosome 15. Carcinogenesis (2015) 0.87

SNP set association analysis for genome-wide association studies. PLoS One (2013) 0.85

Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival. Oncotarget (2015) 0.85

Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. Toxicol Sci (2015) 0.84

Quantitative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex. PLoS One (2013) 0.83

A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer. PLoS One (2015) 0.82

A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility. Carcinogenesis (2014) 0.82

Systematical analyses of variants in CTCF-binding sites identified a novel lung cancer susceptibility locus among Chinese population. Sci Rep (2015) 0.80

Pathway analysis for genome-wide association study of lung cancer in Han Chinese population. PLoS One (2013) 0.80

Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung. Carcinogenesis (2014) 0.80

Statistical analysis for genome-wide association study. J Biomed Res (2014) 0.80

Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nat Genet (2016) 0.79

The emerging role of GATA transcription factors in development and disease. Expert Rev Mol Med (2016) 0.79

A functional polymorphism in the 3'-UTR of PXR interacts with smoking to increase lung cancer risk in southern and eastern Chinese smoker. Int J Mol Sci (2014) 0.78

Tobacco smoking and methylation of genes related to lung cancer development. Oncotarget (2016) 0.78

The MKK7 p.Glu116Lys Rare Variant Serves as a Predictor for Lung Cancer Risk and Prognosis in Chinese. PLoS Genet (2016) 0.78

Classification of non-small cell lung cancer based on copy number alterations. PLoS One (2014) 0.77

Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations. Am J Hum Genet (2015) 0.77

Potentially functional polymorphisms in PAK1 are associated with risk of lung cancer in a Chinese population. Cancer Med (2015) 0.76

The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population. Sci Rep (2015) 0.76

Genetic polymorphisms and haplotypes of TRAIL gene correlate with NSCLC susceptibility in a group of Chinese patients. Int J Clin Exp Med (2015) 0.75

A common CD55 rs2564978 variant is associated with the susceptibility of non-small cell lung cancer. Oncotarget (2017) 0.75

Potentially Functional Polymorphisms in POU5F1 Gene Are Associated with the Risk of Lung Cancer in Han Chinese. Biomed Res Int (2015) 0.75

Familial Lung Cancer: A Brief History from the Earliest Work to the Most Recent Studies. Genes (Basel) (2017) 0.75

Progress of cancer genomics. Thorac Cancer (2015) 0.75

Necessity of organized low-dose computed tomography screening for lung cancer: From epidemiologic comparisons between China and the Western nations. Oncotarget (2016) 0.75

Identification of an SCLC susceptibility rs7963551 genetic polymorphism in a previously GWAS-identified 12p13.33 RAD52 lung cancer risk locus in the Chinese population. Int J Clin Exp Med (2015) 0.75

Vitamin D-Related Gene Polymorphisms, Plasma 25-Hydroxy-Vitamin D, Cigarette Smoke and Non-Small Cell Lung Cancer (NSCLC) Risk. Int J Mol Sci (2016) 0.75

Functional genetic polymorphisms in PP2A subunit genes confer increased risks of lung cancer in southern and eastern Chinese. PLoS One (2013) 0.75

Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep (2017) 0.75

Genetic variants in regulatory regions of microRNAs are associated with lung cancer risk. Oncotarget (2016) 0.75

Risk assessment models for genetic risk predictors of lung cancer using two-stage replication for Asian and European populations. Oncotarget (2016) 0.75

Articles cited by this

Population genomics of human gene expression. Nat Genet (2007) 24.49

A genome-wide association study of global gene expression. Nat Genet (2007) 22.98

Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature (2008) 18.21

Understanding mechanisms underlying human gene expression variation with RNA sequencing. Nature (2010) 16.86

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10

Transcriptome genetics using second generation sequencing in a Caucasian population. Nature (2010) 14.85

A survey of genetic human cortical gene expression. Nat Genet (2007) 12.04

Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28

High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet (2008) 9.68

A large-scale, consortium-based genomewide association study of asthma. N Engl J Med (2010) 9.17

Protein serine/threonine kinases. Annu Rev Biochem (1987) 8.42

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One (2010) 7.48

Lung cancer susceptibility locus at 5p15.33. Nat Genet (2008) 5.99

Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet (2008) 5.43

Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85

B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. Cancer Cell (2010) 2.44

Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet (2010) 1.90

The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90

Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells. Cancer Res (1994) 1.85

Expression of VDR and CYP24A1 mRNA in human tumors. Cancer Chemother Pharmacol (2005) 1.78

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nat Genet (2010) 1.78

Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming. J Immunol (2005) 1.75

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest (2011) 1.59

Human non-small cell lung cancer cells express a type 2 cytokine pattern. Cancer Res (1995) 1.44

p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase. Science (2006) 1.40

Clinical validity of the lung cancer biomarkers identified by bioinformatics analysis of public expression data. Cancer Res (2007) 1.38

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. J Cell Biol (2011) 1.34

Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Mol Cell Biol (2011) 1.29

c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J (2007) 1.27

A dual role for the immune response in a mouse model of inflammation-associated lung cancer. J Clin Invest (2011) 1.25

CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma. Clin Cancer Res (2010) 1.23

Local expression of antiinflammatory cytokines in cancer. J Clin Invest (1993) 1.21

A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. Hum Mol Genet (2010) 1.17

The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages. Toxicol Sci (2009) 1.03

BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers. Oncogene (2011) 1.03

The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. Cancer Biol Ther (2006) 1.01

Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron. Biochem Pharmacol (2009) 0.99

The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations. Hum Genet (2011) 0.96

Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer. Am J Respir Cell Mol Biol (2010) 0.94

Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses. Am J Respir Cell Mol Biol (2009) 0.84

ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. PLoS One (2011) 0.80

A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy. Cancer Sci (2010) 0.78

Articles by these authors

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med (2009) 46.35

Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet (2010) 26.48

Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res (2004) 21.36

International network of cancer genome projects. Nature (2010) 20.35

ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76

A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea. Nature (2009) 15.06

Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 13.71

Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med (2007) 12.24

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78

Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet (2008) 10.52

Interrogating a high-density SNP map for signatures of natural selection. Genome Res (2002) 10.33

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med (2007) 9.80

Global burden of childhood pneumonia and diarrhoea. Lancet (2013) 9.28

Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science (2004) 9.10

A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat Genet (2004) 8.55

Assemblathon 1: a competitive assessment of de novo short read assembly methods. Genome Res (2011) 8.38

Evaluation of gene expression measurements from commercial microarray platforms. Nucleic Acids Res (2003) 8.08

Sequencing and analysis of Neanderthal genomic DNA. Science (2006) 8.06

Rapid whole-genome mutational profiling using next-generation sequencing technologies. Genome Res (2008) 8.01

Mapping human genetic diversity in Asia. Science (2009) 7.40

Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet (2008) 7.36

Statistical analysis of real-time PCR data. BMC Bioinformatics (2006) 7.31

A large-scale analysis of mRNA polyadenylation of human and mouse genes. Nucleic Acids Res (2005) 7.24

Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07

Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science (2011) 6.93

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69

Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr (2002) 6.19

A myocardial lineage derives from Tbx18 epicardial cells. Nature (2008) 6.15

Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol (2010) 5.92

Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet (2004) 5.83

Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science (2007) 5.69

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature (2002) 5.61

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol (2008) 5.55

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature (2007) 5.54

Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature (2006) 5.52

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51

Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet (2008) 5.43

Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science (2007) 5.19

Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum (2005) 5.18

Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst (2003) 5.09

ESPRIT: estimating species richness using large collections of 16S rRNA pyrosequences. Nucleic Acids Res (2009) 4.93

A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88

Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study. J Clin Oncol (2005) 4.82

Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet (2003) 4.67

Maternal deaths averted by contraceptive use: an analysis of 172 countries. Lancet (2012) 4.65

Microbial production of recalcitrant dissolved organic matter: long-term carbon storage in the global ocean. Nat Rev Microbiol (2010) 4.58

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46

A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China. Lancet Oncol (2008) 4.43

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature (2010) 4.38

Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell (2010) 4.37

ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32

Plants and people from the Early Neolithic to Shang periods in North China. Proc Natl Acad Sci U S A (2007) 4.30

Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. Am J Hum Genet (2002) 4.29

Patterns and implications of gene gain and loss in the evolution of Prochlorococcus. PLoS Genet (2007) 4.25

Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25

A risk model for prediction of lung cancer. J Natl Cancer Inst (2007) 4.25

Experimental factors affecting PCR-based estimates of microbial species richness and evenness. ISME J (2010) 4.15

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat Genet (2013) 4.03

Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet (2010) 4.01

PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet (2005) 3.95

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. J Neurosci (2005) 3.92

Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91

Maize inbreds exhibit high levels of copy number variation (CNV) and presence/absence variation (PAV) in genome content. PLoS Genet (2009) 3.88

Test for interaction between two unlinked loci. Am J Hum Genet (2006) 3.88

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A (2003) 3.85

Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis. Am J Hum Genet (2004) 3.83

Characterization of BRCA1 and BRCA2 mutations in a large United States sample. J Clin Oncol (2006) 3.73

Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families. Arthritis Rheum (2003) 3.73

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med (2009) 3.70

The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J Natl Cancer Inst (2008) 3.67

Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension (2002) 3.66

The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle. Genes Dev (2006) 3.58

Rationally designed, polymeric, extended metal-ciprofloxacin complexes. Chemistry (2005) 3.56

Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest (2008) 3.53

Long-term analgesic use after low-risk surgery: a retrospective cohort study. Arch Intern Med (2012) 3.52

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet (2009) 3.52

Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers. Nat Biotechnol (2011) 3.51