MicroRNA-212 functions as an epigenetic-silenced tumor suppressor involving in tumor metastasis and invasion of gastric cancer through down-regulating PXN expression.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 26693054)

Published in Am J Cancer Res on September 15, 2015

Authors

Daojiang Li1, Zhengrong Li2, Jianbo Xiong1, Binbin Gong3, Guoyang Zhang1, Chao Cao1, Zhigang Jie2, Yi Liu2, Yi Cao2, Yufeng Yan4, Hong Xiong4, Lingyu Qiu4, Miantian Yang4, Hongping Chen5, Shuping Jiang5, Xiongwen Yang3, Heping Chen4

Author Affiliations

1: Department of Gastrointestinal Surgery, First Affiliated Hospital, Nanchang University Nanchang 330000, Jiangxi Province, China ; Nanchang University Medical College Nanchang 330000, Jiangxi Province, China.
2: Department of Gastrointestinal Surgery, First Affiliated Hospital, Nanchang University Nanchang 330000, Jiangxi Province, China.
3: Nanchang University Medical College Nanchang 330000, Jiangxi Province, China.
4: The Key Laboratory of Basic Pharmacology, School of Pharmaceutical Science, Nanchang University Nanchang 330006, Jiangxi Province, China.
5: Department of Histology and Embryology, Medical College, Nanchang University Bayi Road 603, Nanchang 330006, China.

Articles cited by this

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17

Cancer statistics, 2014. CA Cancer J Clin (2014) 72.81

Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol (2014) 7.41

MicroRNAs--the micro steering wheel of tumour metastases. Nat Rev Cancer (2009) 5.47

Paxillin: adapting to change. Physiol Rev (2004) 4.48

Cell-matrix adhesion. J Cell Physiol (2007) 4.45

Paxillin and focal adhesion signalling. Nat Cell Biol (2000) 4.37

MicroRNAs in biological processes and carcinogenesis. Carcinogenesis (2006) 2.14

Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. PLoS One (2010) 1.77

DNA methylation and microRNA dysregulation in cancer. Mol Oncol (2012) 1.69

DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect. Int J Cancer (2009) 1.66

Paxillin. Int J Biochem Cell Biol (1998) 1.55

Regulation of microRNAs in cancer metastasis. Biochim Biophys Acta (2014) 1.53

Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis (2010) 1.52

Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting. Cancer Res (2010) 1.44

Genome-wide profiling of chromatin signatures reveals epigenetic regulation of MicroRNA genes in colorectal cancer. Cancer Res (2011) 1.40

Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. Carcinogenesis (2011) 1.38

miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int J Cancer (2010) 1.37

miR-212 increases tumor necrosis factor-related apoptosis-inducing ligand sensitivity in non-small cell lung cancer by targeting the antiapoptotic protein PED. Cancer Res (2010) 1.36

Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer. Carcinogenesis (2012) 1.32

Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis. Biochem Biophys Res Commun (2006) 1.28

MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia. Oncogene (2011) 1.27

Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology (2013) 1.16

MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer. Med Oncol (2011) 1.15

Down-regulation of miR-212 expression by DNA hypermethylation in human gastric cancer cells. Med Oncol (2010) 1.03

The prognostic relevance of miR-212 expression with survival in cytogenetically and molecularly heterogeneous AML. Leukemia (2012) 1.02

Epigenetic regulation of miR-212 expression in lung cancer. PLoS One (2011) 1.01

Potentially predictive microRNAs of gastric cancer with metastasis to lymph node. World J Gastroenterol (2011) 0.99

MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2. J Cell Biochem (2013) 0.98

Paxillin promotes tumor progression and predicts survival and relapse in oral cavity squamous cell carcinoma by microRNA-218 targeting. Carcinogenesis (2014) 0.97

Assessment of the quality of surgery within randomised controlled trials for the treatment of gastro-oesophageal cancer: a systematic review. Lancet Oncol (2014) 0.94

Abnormal expression of paxillin correlates with tumor progression and poor survival in patients with gastric cancer. J Transl Med (2013) 0.92

MicroRNA-212 inhibits osteosarcoma cells proliferation and invasion by down-regulation of Sox4. Cell Physiol Biochem (2014) 0.91

The expression and clinical significance of miR-132 in gastric cancer patients. Diagn Pathol (2014) 0.90

Epigenetic silencing of miR-137 is a frequent event in gastric carcinogenesis. Mol Carcinog (2015) 0.90

Methylation-associated silencing of MicroRNA-335 contributes tumor cell invasion and migration by interacting with RASA1 in gastric cancer. Am J Cancer Res (2014) 0.90

Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer. Cancer Biol Ther (2013) 0.89

Methylation-associated silencing of miR-495 inhibit the migration and invasion of human gastric cancer cells by directly targeting PRL-3. Biochem Biophys Res Commun (2014) 0.88

Metastasis suppressor microRNA-335 targets the formin family of actin nucleators. PLoS One (2013) 0.87

LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6. Oncogenesis (2014) 0.85

A potential regulatory loop between Lin28B:miR‑212 in androgen-independent prostate cancer. Int J Oncol (2014) 0.83

Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212. Genes Chromosomes Cancer (2015) 0.83

Epigenetic regulation of microRNAs in gastric cancer. Dig Dis Sci (2013) 0.83

Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas. Oncol Lett (2013) 0.78

MicroRNAs in gastric cancer metastasis. Crit Rev Eukaryot Gene Expr (2014) 0.78