Published in Bioessays on January 03, 2016
Mitophagy plays a central role in mitochondrial ageing. Mamm Genome (2016) 0.77
Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome. Semin Cancer Biol (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet (2001) 22.46
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
A genomic view of alternative splicing. Nat Genet (2002) 12.62
Nature, nurture, or chance: stochastic gene expression and its consequences. Cell (2008) 12.13
Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature (2004) 11.59
Alternative splicing: increasing diversity in the proteomic world. Trends Genet (2001) 10.44
Noise in gene expression: origins, consequences, and control. Science (2005) 9.64
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell (2007) 9.20
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science (2000) 8.64
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet (2006) 6.52
Dynamic proteomics of individual cancer cells in response to a drug. Science (2008) 5.43
Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature (2009) 4.98
Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet (1998) 4.67
The energetics of genome complexity. Nature (2010) 4.58
Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature (2010) 3.73
Alternative splicing and disease. Biochim Biophys Acta (2008) 3.47
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci U S A (2005) 3.42
Living with noisy genes: how cells function reliably with inherent variability in gene expression. Annu Rev Biophys Biomol Struct (2007) 3.36
Unbalanced alternative splicing and its significance in cancer. Bioessays (2006) 3.17
Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res (1990) 3.13
Mitochondria: the next (neurode)generation. Neuron (2011) 3.06
Mitochondrial DNA sequence variation in human evolution and disease. Proc Natl Acad Sci U S A (1994) 2.96
Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature (2013) 2.90
Histone modification: cause or cog? Trends Genet (2011) 2.85
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A (1992) 2.83
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proc Natl Acad Sci U S A (2004) 2.77
Comprehensive association testing of common mitochondrial DNA variation in metabolic disease. Am J Hum Genet (2006) 2.60
Clustering of Caucasian Leber hereditary optic neuropathy patients containing the 11778 or 14484 mutations on an mtDNA lineage. Am J Hum Genet (1997) 2.21
Origins of regulated cell-to-cell variability. Nat Rev Mol Cell Biol (2011) 2.15
Medicine. Mitochondrial replacement, evolution, and the clinic. Science (2013) 2.10
Genomic analysis at the single-cell level. Annu Rev Genet (2011) 1.96
Type 2 diabetes is associated with a common mitochondrial variant: evidence from a population-based case-control study. Hum Mol Genet (2002) 1.87
Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation. Proc Natl Acad Sci U S A (2005) 1.82
A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA. Mol Cell (2005) 1.79
The free-radical theory of ageing--older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support. Bioessays (2012) 1.76
The mitochondrial theory of aging: dead or alive? Aging Cell (2003) 1.76
Decrease of 3243 A-->G mtDNA mutation from blood in MELAS syndrome: a longitudinal study. Am J Hum Genet (2000) 1.71
Recent mitochondrial DNA mutations increase the risk of developing common late-onset human diseases. PLoS Genet (2014) 1.64
Rearranged mitochondrial genomes are present in human oocytes. Am J Hum Genet (1995) 1.63
MtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage. Cell Rep (2014) 1.42
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife (2014) 1.39
A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects. Eur J Hum Genet (2005) 1.36
Epigenetics, epidemiology and mitochondrial DNA diseases. Int J Epidemiol (2012) 1.36
Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming. Proc Natl Acad Sci U S A (2014) 1.27
Mitochondrial 16189 variant, thinness at birth, and type-2 diabetes. ALSPAC study team. Avon Longitudinal Study of Pregnancy and Childhood. Lancet (1999) 1.24
A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians. Diabetologia (2008) 1.24
Bioenergetic origins of complexity and disease. Cold Spring Harb Symp Quant Biol (2011) 1.19
Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns. Hum Genet (2005) 1.18
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase. Ann Med (2003) 1.16
Connecting variability in global transcription rate to mitochondrial variability. PLoS Biol (2010) 1.13
Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells. J Biol Chem (1996) 1.05
Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA. Neurobiol Aging (2000) 1.04
Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect (2014) 1.03
Preventing transmission of maternally inherited mitochondrial DNA diseases. BMJ (2009) 1.02
GENETICS. Mitochondrial-nuclear DNA mismatch matters. Science (2015) 1.00
Mitochondrial regulation of epigenetics and its role in human diseases. Epigenetics (2012) 0.98
Tuning a ménage à trois: co-evolution and co-adaptation of nuclear and organellar genomes in plants. Bioessays (2013) 0.97
The possible role of 10398A and 16189C mtDNA variants in providing susceptibility to T2DM in two North Indian populations: a replicative study. Hum Genet (2006) 0.97
The alternative heart: impact of alternative splicing in heart disease. J Cardiovasc Transl Res (2013) 0.95
The role of mitochondrial haplogroups in primary open angle glaucoma. Br J Ophthalmol (2006) 0.92
A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA. Pharmacol Res (2015) 0.91
Mitochondrial DNA disease and developmental implications for reproductive strategies. Mol Hum Reprod (2014) 0.90
Somatic mtDNA mutations and aging--facts and fancies. Exp Gerontol (2008) 0.90
Mitochondrial-nuclear cross-talk in the aging and failing heart. Cardiovasc Drugs Ther (2006) 0.86
The association of the mitochondrial DNA OriB variant (16184-16193 polycytosine tract) with type 2 diabetes in Europid populations. Diabetologia (2013) 0.83
Global variability in gene expression and alternative splicing is modulated by mitochondrial content. Genome Res (2015) 0.83
A common mitchondrial DNA variant is associated with thinness in mothers and their 20-yr-old offspring. Am J Physiol Endocrinol Metab (2005) 0.83
Mitochondrial replacement therapy: Cautiously replace the master manipulator. Bioessays (2015) 0.79
A biophysical model for transcription factories. BMC Biophys (2013) 0.79