Published in Eur J Hum Genet on February 01, 2005
Comprehensive association testing of common mitochondrial DNA variation in metabolic disease. Am J Hum Genet (2006) 2.60
Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics. PLoS Genet (2006) 1.78
Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am J Hum Genet (2007) 1.76
Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study. Age (Dordr) (2006) 1.31
Cancer type-specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer. BMC Cancer (2010) 1.25
Climate shaped the worldwide distribution of human mitochondrial DNA sequence variation. Proc Biol Sci (2009) 1.20
Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population. Hum Genet (2007) 1.12
Common mitochondrial sequence variants in ischemic stroke. Ann Neurol (2010) 0.97
The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies. J Hum Genet (2013) 0.95
Mitochondrial DNA coding and control region variants as genetic risk factors for type 2 diabetes. Diabetes (2012) 0.94
The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring. BMC Genomics (2007) 0.93
The complete mitochondrial genome of the entomopathogenic nematode Steinernema carpocapsae: insights into nematode mitochondrial DNA evolution and phylogeny. J Mol Evol (2006) 0.92
Mitochondrial DNA sequence variation and neurodegeneration. Hum Genomics (2008) 0.91
Mitochondrial-nuclear epistasis: implications for human aging and longevity. Ageing Res Rev (2010) 0.89
Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants. Biogerontology (2015) 0.86
Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. J Neurovirol (2012) 0.85
NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on the risk of hypertension in middle-aged Japanese men. J Epidemiol (2009) 0.85
May "mitochondrial eve" and mitochondrial haplogroups play a role in neurodegeneration and Alzheimer's disease? Int J Alzheimers Dis (2011) 0.83
Associating mitochondrial DNA variation with complex traits. Am J Hum Genet (2007) 0.83
Mitochondrial polymorphisms are associated both with increased and decreased longevity. Hum Hered (2008) 0.83
Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old. Neurobiol Aging (2013) 0.82
Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans. Neurobiol Aging (2013) 0.81
Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma. Ann Surg (2007) 0.81
Ashkenazi Jewish centenarians do not demonstrate enrichment in mitochondrial haplogroup J. PLoS One (2008) 0.81
Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly. J Alzheimers Dis (2012) 0.81
Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity. PLoS One (2012) 0.80
Female genetic distribution bias in mitochondrial genome observed in Parkinson's Disease patients in northern China. Sci Rep (2015) 0.80
Mitochondrial haplogroups associated with Japanese Alzheimer's patients. J Bioenerg Biomembr (2009) 0.79
Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly. Biochim Biophys Acta (2012) 0.79
mtDNA Mutations and Their Role in Aging, Diseases and Forensic Sciences. Aging Dis (2013) 0.79
MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association. Sci Rep (2017) 0.77
mtDNA germ line variation mediated ROS generates retrograde signaling and induces pro-cancerous metabolic features. Sci Rep (2014) 0.77
Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation. AIDS Res Hum Retroviruses (2013) 0.77
Genetic epidemiology in aging research. J Gerontol A Biol Sci Med Sci (2009) 0.77
Associations between sequence variations in the mitochondrial DNA D-loop region and outcome of hepatocellular carcinoma. Oncol Lett (2016) 0.76
Japanese Alzheimer's disease and other complex disorders diagnosis based on mitochondrial SNP haplogroups. Int J Alzheimers Dis (2012) 0.75
Mitochondrial content is central to nuclear gene expression: Profound implications for human health. Bioessays (2016) 0.75
Genome digging: insight into the mitochondrial genome of Homo. PLoS One (2010) 0.75
Strong association of de novo copy number mutations with autism. Science (2007) 27.84
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30
Breast-cancer risk in families with mutations in PALB2. N Engl J Med (2014) 4.97
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med (2002) 3.96
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res (2004) 3.34
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. Lancet (2004) 2.91
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Bacterial signatures in thrombus aspirates of patients with myocardial infarction. Circulation (2013) 2.81
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60
Cohort profile: the cardiovascular risk in Young Finns Study. Int J Epidemiol (2008) 2.51
High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst (2009) 2.49
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet (2013) 2.36
T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test. Eur Heart J (2007) 2.36
Ideal cardiovascular health in childhood and cardiometabolic outcomes in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation (2012) 2.32
Genetically determined height and coronary artery disease. N Engl J Med (2015) 2.24
Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin. Am J Hum Genet (2005) 2.23
The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event. Am J Hum Genet (2006) 2.18
Self-reported hearing problems among older adults: prevalence and comparison to measured hearing impairment. J Am Acad Audiol (2011) 2.17
High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-analysis. J Am Coll Cardiol (2013) 2.15
Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Circulation (2005) 2.12
Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes. Circulation (2004) 2.11
Exploring the impact of climate on human longevity. Exp Gerontol (2012) 2.03
Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study. J Pediatr (2011) 2.01
A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. PLoS One (2006) 2.01
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. Hum Genet (2002) 2.00
Prevalence of the primary LHON mutations in Northern Finland associated with bilateral optic atrophy and tobacco-alcohol amblyopia. Acta Ophthalmol (2012) 2.00
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults. Diabetes Care (2012) 1.98
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet (2012) 1.97
Treatment for mitochondrial disorders. Cochrane Database Syst Rev (2012) 1.94
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90
FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab (2009) 1.87
Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. Transplantation (2005) 1.82
Long-term leisure-time physical activity and serum metabolome. Circulation (2012) 1.81
Metabolic signatures of insulin resistance in 7,098 young adults. Diabetes (2012) 1.80
Adolescence risk factors are predictive of coronary artery calcification at middle age: the cardiovascular risk in young Finns study. J Am Coll Cardiol (2012) 1.78
Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics. PLoS Genet (2006) 1.78
Carotid artery intima-media thickness in children with type 1 diabetes. Diabetes (2002) 1.78
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. PLoS Genet (2010) 1.76
Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study. Eur Heart J (2008) 1.76
Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am J Hum Genet (2007) 1.76
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler Thromb Vasc Biol (2002) 1.71
Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 Survey. Atherosclerosis (2011) 1.70
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet (2012) 1.68
Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet (2012) 1.68
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. PLoS Genet (2013) 1.64
Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet (2012) 1.64
Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 1.62
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ Cardiovasc Genet (2012) 1.60
Novel injectable bioartificial tissue facilitates targeted, less invasive, large-scale tissue restoration on the beating heart after myocardial injury. Circulation (2005) 1.59
Parental smoking in childhood and brachial artery flow-mediated dilatation in young adults: the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health study. Arterioscler Thromb Vasc Biol (2012) 1.58
Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants. J Child Psychol Psychiatry (2011) 1.58
Circulating metabolite predictors of glycemia in middle-aged men and women. Diabetes Care (2012) 1.57
Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults. Vasc Med (2003) 1.56
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet (2012) 1.55
miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study. Atherosclerosis (2011) 1.54
Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes. Eur J Hum Genet (2005) 1.54
Enhanced predictive power of quantitative TWA during routine exercise testing in the Finnish Cardiovascular Study. J Cardiovasc Electrophysiol (2008) 1.54
Increased serum matrix metalloproteinase 9 levels in systemic lupus erythematosus patients with neuropsychiatric manifestations and brain magnetic resonance imaging abnormalities. Arthritis Rheum (2004) 1.54
Indoleamine 2,3-dioxygenase activation and depressive symptoms: results from the Young Finns Study. Psychosom Med (2012) 1.53
Functional status of centenarians in Tokyo, Japan: developing better phenotypes of exceptional longevity. J Gerontol A Biol Sci Med Sci (2006) 1.52
Genotype-phenotype analysis in patients with giant axonal neuropathy (GAN). Neuromuscul Disord (2007) 1.49
Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6-year follow-up. The cardiovascular risk in Young Finns study. Atherosclerosis (2012) 1.49
Higher maternal body mass index is associated with an increased risk for later type 2 diabetes in offspring. J Pediatr (2012) 1.49
Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation. Liver Transpl (2014) 1.48
Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study. Int J Epidemiol (2010) 1.47
QRS-T morphology measured from exercise electrocardiogram as a predictor of cardiac mortality. Europace (2010) 1.47
High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. Clin Pharmacol Ther (2005) 1.46
Stability of mitochondrial membrane proteins in terrestrial vertebrates predicts aerobic capacity and longevity. Genome Biol Evol (2011) 1.46
The prevalence of peripheral arterial disease and medial arterial calcification in patients with chronic renal failure: requirements for diagnostics. Am J Kidney Dis (2002) 1.46
Genetic determinants of serum testosterone concentrations in men. PLoS Genet (2011) 1.45
A 19-year-old man with myocardial infarction and sitosterolemia. Intern Med (2003) 1.44
Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations. Int J Epidemiol (2008) 1.44