Published in Front Neurosci on December 16, 2015
D-Amino Acids in the Nervous and Endocrine Systems. Scientifica (Cairo) (2016) 0.75
Strength and Aerobic Exercises Improve Spatial Memory in Aging Rats Through Stimulating Distinct Neuroplasticity Mechanisms. Mol Neurobiol (2016) 0.75
Age-dependent changes in autophosphorylation of alpha calcium/calmodulin dependent kinase II in hippocampus and amygdala after contextual fear conditioning. Brain Res Bull (2017) 0.75
The glutamate receptor ion channels. Pharmacol Rev (1999) 15.06
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron (1994) 11.44
Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev (2010) 11.25
Cloned glutamate receptors. Annu Rev Neurosci (1994) 10.58
Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci (2005) 9.17
Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature (1987) 8.89
Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci (2000) 8.20
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci (2002) 7.57
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature (1986) 7.10
NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol (2001) 6.96
Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med (2003) 6.79
Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science (1992) 6.49
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci (2007) 6.26
Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell (2006) 4.53
Molecular cloning and characterization of the rat NMDA receptor. Nature (1991) 4.45
Molecular diversity of the NMDA receptor channel. Nature (1992) 3.76
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A (2000) 3.71
Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors. J Neurophysiol (1998) 3.67
Do thin spines learn to be mushroom spines that remember? Curr Opin Neurobiol (2007) 3.63
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. J Neurosci (2004) 3.61
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci U S A (1995) 3.51
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A (1999) 3.15
A nomenclature for ligand-gated ion channels. Neuropharmacology (2008) 2.93
Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. J Physiol (2005) 2.90
The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat Rev Neurosci (2012) 2.76
Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron (2002) 2.73
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation. Nature (1992) 2.48
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse. Neuropharmacology (2007) 2.39
Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci (2008) 2.29
A role for NMDA-receptor channels in working memory. Nat Neurosci (1998) 2.28
Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Proc Natl Acad Sci U S A (1999) 2.27
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J Neurosci (2001) 2.25
Evolution of the aging brain transcriptome and synaptic regulation. PLoS One (2008) 2.23
Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature (1992) 2.18
A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biol Psychiatry (2008) 2.17
Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J Neurosci (1989) 2.17
Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J Neurosci (2004) 2.15
Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development. J Neurosci (2004) 2.11
Evidence for a tetrameric structure of recombinant NMDA receptors. J Neurosci (1998) 2.10
Clinical applications of N-acetylcysteine. Altern Med Rev (1998) 2.07
Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. Nature (1994) 2.07
NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci (2002) 1.92
3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine. Proc Natl Acad Sci U S A (1987) 1.79
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron (2011) 1.78
Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell (2007) 1.78
Subtype-dependence of NMDA receptor channel open probability. J Neurosci (1999) 1.77
Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation. Trends Neurosci (2002) 1.76
Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J Neurosci (1995) 1.70
Selective modulation of NMDA responses by reduction and oxidation. Neuron (1989) 1.64
Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking. J Neurosci (2006) 1.59
Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells. Mol Pharmacol (1995) 1.58
Serine racemase is predominantly localized in neurons in mouse brain. J Comp Neurol (2008) 1.57
Diversity in NMDA receptor composition: many regulators, many consequences. Neuroscientist (2012) 1.55
The glycine site of the NMDA receptor--five years on. Trends Pharmacol Sci (1993) 1.54
Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron (1994) 1.50
Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus. J Neurosci (1996) 1.48
Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA. J Neurosci (1994) 1.45
Preventive effect of N-acetyl-L-cysteine on oxidative stress and cognitive impairment in hepatic encephalopathy following bile duct ligation. Free Radic Biol Med (2012) 1.44
Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Eur J Neurosci (2007) 1.43
Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol (2003) 1.43
Lack of evidence for the efficacy of memantine in mild Alzheimer disease. Arch Neurol (2011) 1.42
A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat. J Neurosci (2002) 1.41
Calcineurin links Ca2+ dysregulation with brain aging. J Neurosci (2001) 1.41
Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase. Neuron (1996) 1.39
Protein kinase C modulation of NMDA currents: an important link for LTP induction. Trends Neurosci (1992) 1.39
D-cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. Neurosci Lett (1989) 1.38
Involvement of hippocampal synaptic plasticity in age-related memory decline. Brain Res Brain Res Rev (1999) 1.35
Synaptic plasticity. The role of NMDA receptors in learning and memory. Nature (1988) 1.34
Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature (1994) 1.34
Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J Neurosci (2002) 1.32
Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine. Proc Natl Acad Sci U S A (2002) 1.32
Glutathione in disease. Curr Opin Clin Nutr Metab Care (2001) 1.26
Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. J Neuroinflammation (2004) 1.25
Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies. Brain Res Mol Brain Res (1997) 1.24
Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Neuroscience (2006) 1.24
Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II. J Neurosci (2010) 1.24
Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly. J Biol Chem (2007) 1.23
GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity. Philos Trans R Soc Lond B Biol Sci (2013) 1.21
Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain. J Comp Neurol (1993) 1.20
Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling. Mol Pharmacol (2005) 1.20
D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury. FASEB J (2007) 1.20
Age-associated changes in Ca(2+)-dependent processes: relation to hippocampal synaptic plasticity. Hippocampus (1997) 1.19
Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity. Prog Neurobiol (2012) 1.19
Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors. J Physiol (2005) 1.18
The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia. Neurosci Biobehav Rev (2009) 1.18
Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression. Brain Res Mol Brain Res (2000) 1.18
Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease. J Pharmacol Exp Ther (2004) 1.17
Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors. J Neuroinflammation (2004) 1.17
Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation. Curr Opin Neurobiol (2003) 1.17
Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons. Glia (2006) 1.16
Aging of glutamate receptors: correlations between binding and spatial memory performance in mice. Mech Ageing Dev (1998) 1.16
Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex. Cereb Cortex (2011) 1.15
New targets for pharmacological intervention in the glutamatergic synapse. Eur J Pharmacol (2006) 1.15
Efficacy of memantine for agitation in Alzheimer's dementia: a randomised double-blind placebo controlled trial. PLoS One (2012) 1.14
Fractional Ca2+ currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones. J Physiol (1996) 1.14
New insights into the not-so-new NR3 subunits of N-methyl-D-aspartate receptor: localization, structure, and function. Mol Pharmacol (2010) 1.14
Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor. J Neurosci (2001) 1.14
Quisqualate receptor-mediated depression of calcium currents in hippocampal neurons. Neuron (1990) 1.14
Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine. Nature (1992) 1.13
Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration. FASEB J (2010) 1.12