Published in Dis Model Mech on January 01, 2016
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature (2010) 5.81
A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol (2010) 3.70
Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell (2004) 3.33
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat Med (2012) 3.17
The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature (2007) 3.01
Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Nat Med (2015) 2.43
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MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity. Nat Genet (2008) 2.24
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Apical trafficking in epithelial cells: signals, clusters and motors. J Cell Sci (2009) 2.08
Familial diarrhea syndrome caused by an activating GUCY2C mutation. N Engl J Med (2012) 2.04
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet (2003) 1.99
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Loss of syntaxin 3 causes variant microvillus inclusion disease. Gastroenterology (2014) 1.77
COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code. J Cell Biol (2004) 1.70
Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions. Curr Biol (2012) 1.67
Identification of EpCAM as the gene for congenital tufting enteropathy. Gastroenterology (2008) 1.65
Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice. Gastroenterology (2013) 1.62
Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells. Proc Natl Acad Sci U S A (2005) 1.53
Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A (2010) 1.52
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Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease. J Mol Med (Berl) (2015) 1.50
MYO5B and bile salt export pump contribute to cholestatic liver disorder in microvillous inclusion disease. Hepatology (2014) 1.48
Microvillus inclusion disease. In vitro jejunal electrolyte transport. Gastroenterology (1991) 1.44
An in vivo model of human small intestine using pluripotent stem cells. Nat Med (2014) 1.42
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development (2009) 1.38
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Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice. J Clin Invest (2012) 1.31
Recycling endosomes in apical plasma membrane domain formation and epithelial cell polarity. Trends Cell Biol (2010) 1.29
The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genet (2009) 1.29
EpCAM: structure and function in health and disease. Biochim Biophys Acta (2013) 1.27
Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells. J Biol Chem (2000) 1.27
Loss of the NHE2 Na(+)/H(+) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol (2001) 1.25
Apical secretion in epithelial tubes of the Drosophila embryo is directed by the Formin-family protein Diaphanous. Dev Cell (2009) 1.21
STa and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G. Am J Physiol Cell Physiol (2005) 1.21
Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy). Gastroenterology (2010) 1.20
Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model. Hum Mutat (2010) 1.20
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Regulation of the epithelial Na+ channel by peptidases. Curr Top Dev Biol (2007) 1.17
Correlated light and electron microscopy: ultrastructure lights up! Nat Methods (2015) 1.16
SKIV2L mutations cause syndromic diarrhea, or trichohepatoenteric syndrome. Am J Hum Genet (2012) 1.16
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. Am J Hum Genet (2009) 1.15
Epithelial cell-cell junctions and plasma membrane domains. Biochim Biophys Acta (2008) 1.14
Microvillus inclusion disease: a genetic defect affecting apical membrane protein traffic in intestinal epithelium. Traffic (2000) 1.14
DGAT1 mutation is linked to a congenital diarrheal disorder. J Clin Invest (2012) 1.07
Syndromic (phenotypic) diarrhea in early infancy. Orphanet J Rare Dis (2008) 1.05
Update on SLC26A3 mutations in congenital chloride diarrhea. Hum Mutat (2011) 1.03
Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. Nat Cell Biol (2012) 1.03
Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease. J Clin Invest (2014) 1.02
TTC7A mutations disrupt intestinal epithelial apicobasal polarity. J Clin Invest (2014) 1.02
mTrop1/Epcam knockout mice develop congenital tufting enteropathy through dysregulation of intestinal E-cadherin/β-catenin. PLoS One (2012) 1.01
Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol (2013) 1.01
Rab11a is required for apical protein localisation in the intestine. Biol Open (2014) 1.01
Shaping the intestinal brush border. J Cell Biol (2014) 0.99
Myo5b knockout mice as a model of microvillus inclusion disease. Sci Rep (2015) 0.99
An overview and online registry of microvillus inclusion disease patients and their MYO5B mutations. Hum Mutat (2013) 0.99
Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Reports (2014) 0.98
Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity. Traffic (2013) 0.98
CLMP is required for intestinal development, and loss-of-function mutations cause congenital short-bowel syndrome. Gastroenterology (2011) 0.97
Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency. Am J Hum Genet (2005) 0.97
Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes. J Cell Sci (2014) 0.95
Periodic acid-Schiff staining abnormality in microvillous atrophy: photometric and ultrastructural studies. J Pediatr Gastroenterol Nutr (2000) 0.94
Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease. J Pediatr Gastroenterol Nutr (2011) 0.93
Recent progress in congenital diarrheal disorders. Curr Gastroenterol Rep (2011) 0.93
Absence of cell-surface EpCAM in congenital tufting enteropathy. Hum Mol Genet (2013) 0.93
Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency. Gastroenterology (2009) 0.90
Villin immunohistochemistry is a reliable method for diagnosing microvillus inclusion disease. Am J Surg Pathol (2015) 0.90
Expression of Sar1b enhances chylomicron assembly and key components of the coat protein complex II system driving vesicle budding. Arterioscler Thromb Vasc Biol (2011) 0.89
Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation. Dis Model Mech (2014) 0.89
Congenital sucrase-isomaltase deficiency because of an accumulation of the mutant enzyme in the endoplasmic reticulum. Gastroenterology (2003) 0.88
Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes. J Cell Sci (2015) 0.88
Could a swimming creature inform us on intestinal diseases? Lessons from zebrafish. Inflamm Bowel Dis (2014) 0.88
MYO5B mutations in patients with microvillus inclusion disease presenting with transient renal Fanconi syndrome. J Pediatr Gastroenterol Nutr (2012) 0.87
Targeted gene panel sequencing in children with very early onset inflammatory bowel disease--evaluation and prospective analysis. J Med Genet (2014) 0.86
Mechanisms of apical-basal axis orientation and epithelial lumen positioning. Trends Cell Biol (2015) 0.86
Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment. Am J Physiol Gastrointest Liver Physiol (2014) 0.84
Evaluation of intestinal biopsies for pediatric enteropathy: a proposed immunohistochemical panel approach. Am J Surg Pathol (2014) 0.83
Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. PLoS One (2014) 0.83
Congenital diarrhoeal disorders: advances in this evolving web of inherited enteropathies. Nat Rev Gastroenterol Hepatol (2015) 0.83
Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction. J Mol Med (Berl) (2014) 0.83
Membrane dynamics and the regulation of epithelial cell polarity. Int Rev Cytol (2003) 0.82
Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/MUNC18-2 mutations. Pediatr Blood Cancer (2013) 0.82
Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis. PLoS Genet (2014) 0.82
The value of polyclonal carcinoembryonic antigen immunostaining in the diagnosis of microvillous inclusion disease. Hum Pathol (1993) 0.80
Epithelial cell polarity as reflected in enterocytes. Microsc Res Tech (2000) 0.79
Microvillous inclusion disease: report of a case with atypical features. Ultrastruct Pathol (2002) 0.78
A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export. Traffic (2015) 0.77
Autosomal recessive congenital cataract, intellectual disability phenotype linked to STX3 in a consanguineous Tunisian family. Clin Genet (2014) 0.77
An infant with vomiting, diarrhea, and failure to thrive. Chylomicron retention disease. Gastroenterology (2014) 0.76
Microvillous atrophy: atypical presentations. J Pediatr Gastroenterol Nutr (2014) 0.76