Published in Inflamm Bowel Dis on May 01, 2014
Pathogenesis of necrotizing enterocolitis: modeling the innate immune response. Am J Pathol (2014) 0.88
Protective and pro-inflammatory roles of intestinal bacteria. Pathophysiology (2016) 0.77
A zebrafish model of inflammatory lymphangiogenesis. Biol Open (2015) 0.76
IBD. Fishing for missing heritability in IBD. Nat Rev Gastroenterol Hepatol (2015) 0.76
Multiscale analysis of the murine intestine for modeling human diseases. Integr Biol (Camb) (2015) 0.76
The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders. Dis Model Mech (2016) 0.75
Application of Zebrafish Models in Inflammatory Bowel Disease. Front Immunol (2017) 0.75
Value of Organoids from Comparative Epithelia Models. Yale J Biol Med (2015) 0.75
Enhanced anti-inflammatory potential of cinnamate-zinc layered hydroxide in lipopolysaccharide-stimulated RAW 264.7 macrophages. Drug Des Devel Ther (2015) 0.75
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24
Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology (2011) 12.09
Molecular analysis of commensal host-microbial relationships in the intestine. Science (2001) 12.04
Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell (2006) 9.64
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Functional interactions between the gut microbiota and host metabolism. Nature (2012) 7.91
The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol (2008) 7.91
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53
Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol (2011) 6.96
Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A (2004) 5.89
The gut microbiota--masters of host development and physiology. Nat Rev Microbiol (2013) 5.25
Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Proc Natl Acad Sci U S A (2004) 5.16
Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell (2008) 5.09
Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol (2013) 4.34
Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16
Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host Microbe (2007) 3.88
IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am J Physiol Gastrointest Liver Physiol (2006) 3.72
Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study. Gastroenterology (2013) 3.55
A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature (2013) 3.52
Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med (1998) 3.50
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity (2002) 3.46
Evidence for a core gut microbiota in the zebrafish. ISME J (2011) 3.22
MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J Gastroenterol (2005) 3.02
Dextran sodium sulphate colitis mouse model: traps and tricks. J Biomed Biotechnol (2012) 2.97
A comparative map of the zebrafish genome. Genome Res (2000) 2.90
Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation. Dev Biol (2006) 2.67
Ontogeny of the gastrointestinal tract of marine fish larvae. Comp Biochem Physiol C Toxicol Pharmacol (2001) 2.63
Intestinal growth and differentiation in zebrafish. Mech Dev (2005) 2.57
Amelioration of chronic ileitis by nitric oxide synthase inhibition. J Pharmacol Exp Ther (1993) 2.54
The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol (2006) 2.42
Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Dev Biol (2005) 2.38
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. J Clin Invest (2000) 2.27
Inflammatory bowel disease in Asia: a systematic review. J Gastroenterol Hepatol (2012) 2.24
A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. Gastroenterology (2005) 2.17
Development and maturation of the immune system in zebrafish, Danio rerio: a gene expression profiling, in situ hybridization and immunological study. Dev Comp Immunol (2004) 2.10
Paneth cells as a site of origin for intestinal inflammation. Nature (2013) 2.09
Immunology and zebrafish: spawning new models of human disease. Dev Comp Immunol (2008) 2.04
IBD-what role do Proteobacteria play? Nat Rev Gastroenterol Hepatol (2012) 2.03
Environmental and ecological factors that shape the gut bacterial communities of fish: a meta-analysis. Mol Ecol (2012) 2.01
Unique and conserved aspects of gut development in zebrafish. Dev Biol (2003) 1.95
MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis. Cell Microbiol (2007) 1.94
Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish. Cell Host Microbe (2012) 1.93
MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression. Infect Immun (2004) 1.89
Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ. Gastroenterology (2010) 1.80
Host-microbe interactions in the developing zebrafish. Curr Opin Immunol (2010) 1.76
Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish. Dev Cell (2011) 1.72
Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages. Am J Physiol (1994) 1.67
Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. J Immunol (2009) 1.65
Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. J Immunol (2011) 1.63
Host-pathogen interactions made transparent with the zebrafish model. Curr Drug Targets (2011) 1.60
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis (2013) 1.59
A model 450 million years in the making: zebrafish and vertebrate immunity. Dis Model Mech (2012) 1.59
Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases. J Intern Med (2008) 1.48
Epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88. Proc Natl Acad Sci U S A (2010) 1.47
Brain-gut interactions in inflammatory bowel disease. Gastroenterology (2012) 1.42
Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. Gastroenterology (2011) 1.39
MyD88 innate immune function in a zebrafish embryo infection model. Infect Immun (2006) 1.35
Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation. J Immunol (2009) 1.34
Ontogeny of enzymes in the small intestine. Annu Rev Physiol (1985) 1.33
Think small: zebrafish as a model system of human pathology. J Biomed Biotechnol (2012) 1.30
Animal models of inflammatory bowel disease. Prog Mol Biol Transl Sci (2012) 1.29
Fish immunology. Curr Biol (2009) 1.28
Environmental triggers for inflammatory bowel disease. Curr Gastroenterol Rep (2013) 1.26
Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease. Inflamm Bowel Dis (2011) 1.25
Toll-like receptor signaling in bony fish. Vet Immunol Immunopathol (2009) 1.20
Visualizing digestive organ morphology and function using differential fatty acid metabolism in live zebrafish. Dev Biol (2011) 1.19
Toll-like receptors in bony fish: from genomics to function. Dev Comp Immunol (2011) 1.15
Emerging inflammatory bowel disease in saudi outpatients: a report of 693 cases. Saudi J Gastroenterol (2013) 1.14
The gene history of zebrafish tlr4a and tlr4b is predictive of their divergent functions. J Immunol (2009) 1.12
A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents. Dev Dyn (2011) 1.12
Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms. Immunol Lett (2012) 1.11
Reverse genetic approaches in zebrafish. J Genet Genomics (2012) 1.09
Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system. Dis Model Mech (2013) 1.07
Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases? Best Pract Res Clin Gastroenterol (2013) 1.06
The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish. Dis Model Mech (2011) 1.04
Wnt signaling in vertebrate axis specification. Cold Spring Harb Perspect Biol (2013) 1.03
Oxazolone-induced enterocolitis in zebrafish depends on the composition of the intestinal microbiota. Gastroenterology (2009) 1.03
Intestinal microbiota composition in fishes is influenced by host ecology and environment. Mol Ecol (2012) 1.02
Normal anatomy and histology of the adult zebrafish. Toxicol Pathol (2011) 1.01
In vivo analysis of gut function and disease changes in a zebrafish larvae model of inflammatory bowel disease: a feasibility study. Inflamm Bowel Dis (2010) 1.01
Induction of heat shock proteins and their implication in protection against ethanol-induced damage in cultured guinea pig gastric mucosal cells. Gastroenterology (1991) 1.01
Retracted Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid. Chem Biol (2012) 1.00
A new zebrafish model of oro-intestinal pathogen colonization reveals a key role for adhesion in protection by probiotic bacteria. PLoS Pathog (2012) 1.00
Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. BMC Genomics (2010) 0.99
Expression of zebrafish cxcl8 (interleukin-8) and its receptors during development and in response to immune stimulation. Dev Comp Immunol (2009) 0.99
Healing of intestinal inflammation by IL-22. Inflamm Bowel Dis (2012) 0.97
Bacterial community assembly and turnover within the intestines of developing zebrafish. PLoS One (2012) 0.97
Mu opioid signaling protects against acute murine intestinal injury in a manner involving Stat3 signaling. Am J Pathol (2011) 0.96
Increasing incidence and lifetime risk of inflammatory bowel disease in Taiwan: a nationwide study in a low-endemic area 1998-2010. Inflamm Bowel Dis (2013) 0.96
T cells and the thymus in developing zebrafish. Dev Comp Immunol (2004) 0.96
Nutrition and diet in inflammatory bowel disease. Curr Opin Gastroenterol (2013) 0.95
Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. Cell Microbiol (2014) 0.95
Intestinal inflammation targets cancer-inducing activity of the microbiota. Science (2012) 7.54
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 4.37
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology (2003) 3.51
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science (2010) 2.99
The microbiome and cancer. Nat Rev Cancer (2013) 2.86
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One (2009) 2.79
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One (2010) 2.60
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity (2012) 2.07
Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci (2002) 1.95
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol (2004) 1.84
Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis. J Immunol (2007) 1.82
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells. Blood (2004) 1.58
Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm Bowel Dis (2007) 1.55
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines. J Biol Chem (2002) 1.48
Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem (2005) 1.41
Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. Gastroenterology (2011) 1.39
NF-kappaB and the intestine: friend or foe? Inflamm Bowel Dis (2008) 1.33
Think small: zebrafish as a model system of human pathology. J Biomed Biotechnol (2012) 1.30
Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. J Immunol (2007) 1.22
Stochastic changes over time and not founder effects drive cage effects in microbial community assembly in a mouse model. ISME J (2013) 1.21
Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition. PLoS One (2012) 1.19
Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis. Inflamm Bowel Dis (2011) 1.16
The struggle within: microbial influences on colorectal cancer. Inflamm Bowel Dis (2011) 1.15
Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. Gastroenterology (2009) 1.15
Gut microbiota and probiotics in colon tumorigenesis. Cancer Lett (2011) 1.12
Interaction between resident luminal bacteria and the host: can a healthy relationship turn sour? J Pediatr Gastroenterol Nutr (2004) 1.10
The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology (2005) 1.10
Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS One (2009) 1.07
Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis. PLoS One (2012) 1.06
Serum amyloid A activates NF-kappaB and proinflammatory gene expression in human and murine intestinal epithelial cells. Eur J Immunol (2005) 1.06
Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer. Mol Pharmacol (2008) 1.06
Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice. J Biol Chem (2008) 1.04
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene (2005) 1.04
Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation. Sci Rep (2013) 1.02
Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells. J Cell Physiol (2004) 1.02
Gnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection. PLoS One (2009) 1.02
Toll-like receptor 9-dependent macrophage activation by Entamoeba histolytica DNA. Infect Immun (2007) 1.01
Inhibition of macrophage nuclear factor-kappaB leads to a dominant anti-inflammatory phenotype that attenuates glomerular inflammation in vivo. Am J Pathol (2005) 1.00
Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling. Gastroenterology (2011) 0.98
The complex interplay between inflammation, the microbiota and colorectal cancer. Gut Microbes (2013) 0.98
Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda. Inflamm Bowel Dis (2013) 0.97
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity (2012) 0.97
Mu opioid signaling protects against acute murine intestinal injury in a manner involving Stat3 signaling. Am J Pathol (2011) 0.96
PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response. PLoS One (2011) 0.96
Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis. PLoS One (2009) 0.95
Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. Cell Microbiol (2014) 0.95
Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. Am J Pathol (2013) 0.94
Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer. Am J Physiol Gastrointest Liver Physiol (2011) 0.93
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock (2011) 0.93
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One (2012) 0.92
Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes. J Cell Physiol (2006) 0.91
Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses. Dis Model Mech (2012) 0.91
NF-kappaB-inducing kinase restores defective IkappaB kinase activity and NF-kappaB signaling in intestinal epithelial cells. Cell Signal (2004) 0.91
Diet, microbiome, and the intestinal epithelium: an essential triumvirate? Biomed Res Int (2013) 0.91
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. PLoS One (2007) 0.89
Adenosine is a negative regulator of NF-kappaB and MAPK signaling in human intestinal epithelial cells. Cell Immunol (2005) 0.88
VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer. Sci Rep (2013) 0.87
Colorectal cancer: CRC--all about microbial products and barrier function? Nat Rev Gastroenterol Hepatol (2012) 0.87
Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci (2012) 0.85
Phosphatidylinositol 3-kinase-γ signaling promotes Campylobacter jejuni-induced colitis through neutrophil recruitment in mice. J Immunol (2012) 0.83
Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Am J Physiol Cell Physiol (2002) 0.82
Regulation and functional impact of lipopolysaccharide induced Nod2 gene expression in the murine epididymal epithelial cell line PC1. Immunology (2008) 0.82
Chemotherapy, immunity and microbiota--a new triumvirate? Nat Med (2014) 0.82
Intestinal epithelial cells and innate immunity in the intestine: is CARD15/Nod2 another player? Gastroenterology (2003) 0.79
The microbiota is essential for the generation of black tea theaflavins-derived metabolites. PLoS One (2012) 0.79
Structural identification of mouse fecal metabolites of theaflavin 3,3'-digallate using liquid chromatography tandem mass spectrometry. J Chromatogr A (2011) 0.79
Role of NF-kappaB in inflammatory disorders: just when you thought you knew everything! J Pediatr Gastroenterol Nutr (2004) 0.78
MyD88 signaling in the intestine: Dr Jekyll and Mr Hyde? Gastroenterology (2010) 0.78
Epithelial cell-specific MyD88 signaling mediates ischemia/reperfusion-induced intestinal injury independent of microbial status. Inflamm Bowel Dis (2013) 0.78
The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention. Inflamm Bowel Dis (2015) 0.78
Time dependency and topography of hepatic nuclear factor κB activation after hemorrhagic shock and resuscitation in mice. Shock (2012) 0.77
Ubiquitin protein modification and signal transduction: implications for inflammatory bowel diseases. Inflamm Bowel Dis (2005) 0.76
From promotion to management: the wide impact of bacteria on cancer and its treatment. Bioessays (2014) 0.76
[Microbial dysbiosis, a new risk factor in colorectal cancer?]. Med Sci (Paris) (2013) 0.76
Gut Microbiota and a Selectively Bred Taste Phenotype: A Novel Model of Microbiome-Behavior Relationships. Psychosom Med (2016) 0.76
Microbiota in chronic mucosal inflammation. Int J Inflam (2011) 0.75
Novel insights into microbiome in colitis and colorectal cancer. Curr Opin Gastroenterol (2017) 0.75