Pharmacology and regulation of ATP-sensitive K+ channels.

ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release. Proc Natl Acad Sci U S A (1993) 1.11

Intracellular ATP can regulate afferent arteriolar tone via ATP-sensitive K+ channels in the rabbit. J Clin Invest (1992) 0.92

Ion channels. Diabetologia (1992) 0.87

ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target. Ageing Res Rev (2015) 0.81

K channel openers activate different K channels in vascular smooth muscle cells. Cardiovasc Drugs Ther (1993) 0.79

ATP-regulated K+ channels in cardiac muscle. Nature (1983) 10.05

Intracellular ATP directly blocks K+ channels in pancreatic B-cells. Nature (1984) 6.06

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells. Nature (1985) 5.52

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch (1986) 3.51

Effect of anoxia on ion distribution in the brain. Physiol Rev (1985) 3.28

Galanin - a novel biologically active peptide from porcine intestine. FEBS Lett (1983) 3.12

The sulphonylurea receptor may be an ATP-sensitive potassium channel. Lancet (1985) 2.77

Voltage-dependent ATP-sensitive potassium channels of skeletal muscle membrane. Nature (1985) 2.68

Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP. Pflugers Arch (1985) 2.66

Inward-rectifying channels in isolated patches of the heart cell membrane: ATP-dependence and comparison with cell-attached patches. Pflugers Arch (1984) 2.59

Studies of the unitary properties of adenosine-5'-triphosphate-regulated potassium channels of frog skeletal muscle. J Physiol (1987) 2.48

Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells. Experientia (1984) 2.43

The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells. J Biol Chem (1987) 2.24

Cyclic changes in potential and resistance of the beta-cell membrane induced by glucose in islets of Langerhans from mouse. J Physiol (1978) 2.11

Interaction of diazoxide, tolbutamide and ATP4- on nucleotide-dependent K+ channels in an insulin-secreting cell line. J Membr Biol (1987) 1.77

Adenosine-5'-triphosphate-sensitive ion channels in neonatal rat cultured central neurones. Pflugers Arch (1988) 1.77

Sulfonylurea receptors, ion channels, and fruit flies. Diabetes (1988) 1.68

A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line. Proc Natl Acad Sci U S A (1986) 1.62

Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels. J Biol Chem (1988) 1.61

Intracellular Ca2+ activates phospholipase C. Trends Neurosci (1988) 1.49

Antidiabetic sulfonylureas: localization of binding sites in the brain and effects on the hyperpolarization induced by anoxia in hippocampal slices. Brain Res (1989) 1.38

Effects of hypoxia on rat hippocampal neurones in vitro. J Physiol (1987) 1.37

Effects of protein kinase C activators on cardiac Ca2+ channels. Nature (1988) 1.37

Changes of membrane currents in cardiac cells induced by long whole-cell recordings and tolbutamide. Pflugers Arch (1987) 1.35

Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein. EMBO J (1989) 1.35

Tolbutamide stimulation and inhibition of insulin release: studies of the underlying ionic mechanisms in isolated rat islets. Diabetologia (1980) 1.34

Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. Circ Res (1988) 1.31

The antidiabetic sulfonylurea glibenclamide is a potent blocker of the ATP-modulated K+ channel in insulin secreting cells. Biochem Biophys Res Commun (1987) 1.27

Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP. Proc Natl Acad Sci U S A (1989) 1.26

ATP-sensitive K+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone. Proc Natl Acad Sci U S A (1988) 1.26

Activators of protein kinase C depolarize insulin-secreting cells by closing K+ channels. EMBO J (1988) 1.25

Somatostatin in the central nervous system: physiology and pathological modifications. Prog Neurobiol (1986) 1.24

Somatostatin: mechanism of action in pancreatic islet beta-cells. Diabetes (1981) 1.24

Vasopressin modulates the spontaneous electrical activity in aortic cells (line A7r5) by acting on three different types of ionic channels. Proc Natl Acad Sci U S A (1988) 1.20

Characterization, purification, and affinity labeling of the brain [3H]glibenclamide-binding protein, a putative neuronal ATP-regulated K+ channel. Proc Natl Acad Sci U S A (1988) 1.19

Mechanism of galanin-inhibited insulin release. Occurrence of a pertussis-toxin-sensitive inhibition of adenylate cyclase. Eur J Biochem (1988) 1.16

Galanin inhibits insulin secretion and induces hyperglycemia in dogs. Diabetes (1985) 1.12

Metabolic regulation of the K(ATP) and a maxi-K(V) channel in the insulin-secreting RINm5F cell. J Gen Physiol (1988) 1.11

Galanin: a novel pancreatic neuropeptide. Am J Physiol (1986) 1.11

Somatostatin, an inhibitor of ACTH secretion, decreases cytosolic free calcium and voltage-dependent calcium current in a pituitary cell line. J Neurosci (1986) 1.06

Inhibition of 3H-glibenclamide binding to sulfonylurea receptors by oral antidiabetics. Arzneimittelforschung (1985) 1.02

Direct photoaffinity labeling of the putative sulfonylurea receptor in rat beta-cell tumor membranes by [3H]glibenclamide. FEBS Lett (1988) 1.01

Interaction of sulfonylurea with the pancreatic B-cell. Experientia (1984) 0.98

A binding site for [3H]glipizide in the rat cerebral cortex. Eur J Pharmacol (1987) 0.97

Distinct mechanisms for two amplification systems of insulin release. Biochem J (1987) 0.95

A potassium conductance contributes to the action of somatostatin-14 to suppress ACTH secretion. Brain Res (1988) 0.94

Requirement of GTP on somatostatin-induced K+ current in human pituitary tumor cells. Proc Natl Acad Sci U S A (1988) 0.92

Galanin receptors in a hamster pancreatic beta-cell tumor: identification and molecular characterization. Endocrinology (1987) 0.92

Evidence for two distinct modalities of CA2+ influx into pancreatic B cell. Am J Physiol (1982) 0.91

Electrophysiological evidence for the inhibition of potassium permeability in pancreatic beta-cells by glibenclamide. Q J Exp Physiol (1984) 0.90

Somatostatin activates glibenclamide-sensitive and ATP-regulated K+ channels in insulinoma cells via a G-protein. FEBS Lett (1988) 0.88

Galanin and the endocrine pancreas. FEBS Lett (1988) 0.87

Insulin release from a cloned hamster B-cell line (HIT-T15). The effects of glucose, amino acids, sulphonylureas and colchicine. Biochem Biophys Res Commun (1986) 0.87

Galanin inhibits glucose-stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2+ concentration. Biochem Biophys Res Commun (1986) 0.83

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature (1996) 8.63

A proton-gated cation channel involved in acid-sensing. Nature (1997) 6.98

Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation. Nature (1992) 5.45

H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels. Curr Opin Neurobiol (1998) 3.80

Inhalational anesthetics activate two-pore-domain background K+ channels. Nat Neurosci (1999) 3.73

TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J (1997) 3.60

A mammalian two pore domain mechano-gated S-like K+ channel. EMBO J (1998) 3.58

Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons. J Biol Chem (1997) 3.24

A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem (1997) 3.23

Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol (2000) 3.15

Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J (1996) 3.08

TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J (1996) 3.06

TREK-1, a K+ channel involved in neuroprotection and general anesthesia. EMBO J (2004) 2.85

Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels. J Biol Chem (2000) 2.85

TREK-1 is a heat-activated background K(+) channel. EMBO J (2000) 2.82

[3H]nitrendipine receptors in skeletal muscle. J Biol Chem (1983) 2.77

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. EMBO J (1998) 2.55

Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem (1999) 2.55

Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett (1993) 2.52

Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J Neurosci (2001) 2.51

Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel. J Biol Chem (1994) 2.44

Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. J Biol Chem (1998) 2.37

Inner ear defects induced by null mutation of the isk gene. Neuron (1996) 2.34

Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature (1995) 2.32

KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J (2000) 2.25

The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells. J Biol Chem (1987) 2.24

Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK. J Biol Chem (2000) 2.16

The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. J Biol Chem (1996) 2.15

Lipid and mechano-gated 2P domain K(+) channels. Curr Opin Cell Biol (2001) 2.12

Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett (1994) 2.10

The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc Natl Acad Sci U S A (1994) 2.09

TRAAK is a mammalian neuronal mechano-gated K+ channel. J Biol Chem (1999) 2.04

Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor. Proc Natl Acad Sci U S A (1982) 2.01

Calcium channels: molecular pharmacology, structure and regulation. J Membr Biol (1988) 1.99

Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels. J Biol Chem (1995) 1.98

The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions. Biochem Biophys Res Commun (1984) 1.96

Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. J Biol Chem (2000) 1.92

The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. EMBO J (2001) 1.91

The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol (1985) 1.90

The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK. Mol Pharmacol (2000) 1.87

Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. EMBO J (1997) 1.84

Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel. J Biol Chem (1995) 1.80

Polyunsaturated fatty acids are potent neuroprotectors. EMBO J (2000) 1.80

Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity. J Biol Chem (1997) 1.79

The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. J Biol Chem (1997) 1.76

Trypsin-pancreatic trypsin inhibitor association. Dynamics of the interaction and role of disulfide bridges. Biochemistry (1972) 1.76

Zn2+ and H+ are coactivators of acid-sensing ion channels. J Biol Chem (2001) 1.73

External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. Proc Natl Acad Sci U S A (1994) 1.73

Molecular mechanism of action of the vasoconstrictor peptide endothelin. Biochem Biophys Res Commun (1988) 1.72

Cloning and expression of a membrane receptor for secretory phospholipases A2. J Biol Chem (1994) 1.72

Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels. Science (1990) 1.72

Receptors for a growing family of secreted phospholipases A2. Trends Pharmacol Sci (1999) 1.69

The regulation of the intracellular pH in cells from vertebrates. Eur J Biochem (1988) 1.68

Flip-flop mechanisms in enzymology. A model: the alkaline phosphatase of Escherichia coli. Eur J Biochem (1971) 1.67

Different types of Ca2+ channels in mammalian skeletal muscle cells in culture. Proc Natl Acad Sci U S A (1986) 1.66

H(+)-gated cation channels. Ann N Y Acad Sci (1999) 1.66

Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers. Biochem Biophys Res Commun (1995) 1.65

The role of the Na+/H+ exchange system in cardiac cells in relation to the control of the internal Na+ concentration. A molecular basis for the antagonistic effect of ouabain and amiloride on the heart. J Biol Chem (1984) 1.64

Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning. Proc Natl Acad Sci U S A (1995) 1.62

Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels. J Biol Chem (1988) 1.61

The protein IsK is a dual activator of K+ and Cl- channels. Nature (1993) 1.61

Activation of the nuclear factor-kappaB is a key event in brain tolerance. J Neurosci (2001) 1.60

Riluzole prevents ischemic spinal cord injury caused by aortic crossclamping. J Thorac Cardiovasc Surg (1999) 1.57

Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge. EMBO J (1996) 1.57

Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone. J Biol Chem (1994) 1.56

Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. EMBO J (1997) 1.55

New modulatory alpha subunits for mammalian Shab K+ channels. J Biol Chem (1997) 1.52

The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel. J Biol Chem (1994) 1.51

Functional degenerin-containing chimeras identify residues essential for amiloride-sensitive Na+ channel function. J Biol Chem (1995) 1.50

The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. J Biol Chem (1995) 1.50

Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Proc Natl Acad Sci U S A (1988) 1.49

Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes. J Biol Chem (1986) 1.47

Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes. Proc Natl Acad Sci U S A (1979) 1.43

Susceptibility of cloned K+ channels to reactive oxygen species. Proc Natl Acad Sci U S A (1995) 1.40

Intestinal alkaline phosphatase. Physical properties and quaternary structure. Biochemistry (1974) 1.39

The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel. Purification and subunit composition. J Biol Chem (1985) 1.39

Antidiabetic sulfonylureas: localization of binding sites in the brain and effects on the hyperpolarization induced by anoxia in hippocampal slices. Brain Res (1989) 1.38

Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2. Biochemistry (1992) 1.37

Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J Biol Chem (1999) 1.37

Localization and regulation by steroids of the alpha, beta and gamma subunits of the amiloride-sensitive Na+ channel in colon, lung and kidney. Pflugers Arch (1995) 1.36

Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochem Biophys Res Commun (2001) 1.35

A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps). J Biol Chem (1992) 1.34

Dihydropyridine-sensitive Ca2+ channels in mammalian skeletal muscle cells in culture: electrophysiological properties and interactions with Ca2+ channel activator (Bay K8644) and inhibitor (PN 200-110). Proc Natl Acad Sci U S A (1986) 1.33

Endocytic properties of the M-type 180-kDa receptor for secretory phospholipases A2. J Biol Chem (1996) 1.33