Published in Experientia on October 15, 1984
Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions. J Physiol (1986) 3.46
Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells. J Physiol (1993) 2.47
Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells. J Clin Invest (1992) 2.06
Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets. J Physiol (1999) 2.01
Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing. Biochem J (2004) 1.97
Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets. J Clin Invest (1988) 1.82
Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels. J Physiol (2002) 1.80
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J (2003) 1.77
Properties and calcium-dependent inactivation of calcium currents in cultured mouse pancreatic B-cells. J Physiol (1988) 1.69
Properties of single potassium channels modulated by glucose in rat pancreatic beta-cells. J Physiol (1988) 1.63
Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. J Physiol (2004) 1.60
Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells. J Gen Physiol (1999) 1.59
Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells. J Clin Invest (1993) 1.59
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J (2003) 1.51
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46
Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation. J Clin Invest (2001) 1.46
K(ATP) channels and islet hormone secretion: new insights and controversies. Nat Rev Endocrinol (2013) 1.33
Permeation and gating properties of the L-type calcium channel in mouse pancreatic beta cells. J Gen Physiol (1993) 1.30
Regulation of calcium in pancreatic α- and β-cells in health and disease. Cell Calcium (2011) 1.29
Activators of protein kinase C depolarize insulin-secreting cells by closing K+ channels. EMBO J (1988) 1.25
Cytoplasmic calcium transients due to single action potentials and voltage-clamp depolarizations in mouse pancreatic B-cells. EMBO J (1992) 1.24
Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. J Physiol (2004) 1.20
Block of ATP-regulated and Ca2(+)-activated K+ channels in mouse pancreatic beta-cells by external tetraethylammonium and quinine. J Physiol (1990) 1.17
Voltage-activated currents in guinea pig pancreatic alpha 2 cells. Evidence for Ca2+-dependent action potentials. J Gen Physiol (1988) 1.14
Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels. J Membr Biol (2004) 1.13
Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation. J Physiol (2002) 1.11
The electrical activity of mouse pancreatic beta-cells recorded in vivo shows glucose-dependent oscillations. J Physiol (1995) 1.10
Rubidium and sodium permeability of the ATP-sensitive K+ channel in single rat pancreatic beta-cells. J Physiol (1989) 1.06
Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic β cells: a simulation study. J Gen Physiol (2011) 1.04
How noise and coupling induce bursting action potentials in pancreatic {beta}-cells. Biophys J (2005) 1.03
Effects of 2-ketoisocaproate on insulin release and single potassium channel activity in dispersed rat pancreatic beta-cells. J Physiol (1987) 1.02
Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells. Biochem J (1994) 1.01
Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells. PLoS Biol (2006) 0.97
Interaction of tolbutamide and cytosolic nucleotides in controlling the ATP-sensitive K+ channel in mouse beta-cells. Br J Pharmacol (1994) 0.95
Distinct mechanisms for two amplification systems of insulin release. Biochem J (1987) 0.95
Voltage-activated calcium and potassium currents in human pancreatic beta-cells. J Physiol (1991) 0.95
Adenine nucleotide-induced inhibition of binding of sulphonylureas to their receptor in pancreatic islets. Br J Pharmacol (1992) 0.93
Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells. Br J Pharmacol (1992) 0.92
Sulphonylureas reduce the slowly inactivating D-type outward current in rat hippocampal neurons. J Physiol (1993) 0.90
BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells. J Physiol (2010) 0.90
Nanomechanical analysis of insulinoma cells after glucose and capsaicin stimulation using atomic force microscopy. Acta Pharmacol Sin (2011) 0.87
Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. J Physiol (2014) 0.87
Cyclic adenosine monophosphate differently affects the response of mouse pancreatic beta-cells to various amino acids. J Physiol (1986) 0.87
Insulin secretion: a high-affinity Ca2+ sensor after all? J Gen Physiol (2004) 0.86
Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cells. Biophys J (1999) 0.85
On the mechanism of impaired insulin secretion in chronic renal failure. J Clin Invest (1991) 0.84
Effects of extracellular adenine nucleotides on the electrical, ionic and secretory events in mouse pancreatic beta-cells. Br J Pharmacol (1989) 0.82
Inhibition of the ATP-sensitive potassium channel by class I antiarrhythmic agent, cibenzoline, in rat pancreatic beta-cells. Br J Pharmacol (1993) 0.82
Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays. Pflugers Arch (2011) 0.81
Pharmacology and regulation of ATP-sensitive K+ channels. Pflugers Arch (1989) 0.81
Amantadine and sparteine inhibit ATP-regulated K-currents in the insulin-secreting beta-cell line, HIT-T15. Br J Pharmacol (1991) 0.81
The effect of glucose on insulin release and ion movements in isolated pancreatic islets of rats in old age. J Physiol (1987) 0.79
Amino acid-induced [Ca2+]i oscillations in single mouse pancreatic islets of Langerhans. J Physiol (1995) 0.79
Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells. Pflugers Arch (2015) 0.79
Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets. Biochem J (1991) 0.79
Glucose Evokes Rapid Ca2+ and Cyclic AMP Signals by Activating the Cell-Surface Glucose-Sensing Receptor in Pancreatic β-Cells. PLoS One (2015) 0.79
Adamantane derivatives: a new class of insulin secretagogues. Br J Pharmacol (1987) 0.79
A benchtop closed-loop system controlled by a bio-inspired silicon implementation of the pancreatic beta cell. J Diabetes Sci Technol (2009) 0.78
Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): a paradigm worth exploring. Biochem Pharmacol (2013) 0.77
RyR channels and glucose-regulated pancreatic beta-cells. Eur Biophys J (2008) 0.77
Effects of both glucose and IP3 concentrations on action potentials in pancreatic beta-cells. Eur Biophys J (2007) 0.76
Masked excitatory action of noradrenaline on rat islet beta-cells via activation of phospholipase C. Pflugers Arch (2003) 0.76
Different insulin-secretory responses to calcium-channel blockers in islets of lean and obese (ob/ob) mice. Biochem J (1988) 0.75
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo. Br J Pharmacol (2006) 0.75
Loperamide mobilizes intracellular Ca2+ stores in insulin-secreting HIT-T15 cells. Br J Pharmacol (2003) 0.75
Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture. Br J Cancer (1988) 0.75
Defective regulation of insulin release and transmembrane Ca2+ fluxes by human islet cell tumours. Br J Cancer (1987) 0.75
Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab (2008) 3.96
Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. Endocr Rev (2001) 2.92
Membrane potential of beta-cells in pancreatic islets. Pflugers Arch (1974) 2.74
Cellular composition of the human diabetic pancreas. Diabetologia (1983) 2.71
Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. J Clin Invest (1997) 2.21
Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells. J Clin Invest (1992) 2.06
Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets. J Biol Chem (1993) 1.95
Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells. Biochem Pharmacol (1982) 1.90
D-glucose inhibits potassium efflux from pancreatic islet cells. Nature (1978) 1.86
Electrophysiological evidence for coupling between beta cells of pancreatic islets. Nature (1976) 1.86
Culture duration and conditions affect the oscillations of cytoplasmic calcium concentration induced by glucose in mouse pancreatic islets. Diabetologia (1994) 1.66
Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell. J Biol Chem (1992) 1.64
Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia (1995) 1.63
Interplay between cytoplasmic Ca2+ and the ATP/ADP ratio: a feedback control mechanism in mouse pancreatic islets. Biochem J (1998) 1.59
Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells. J Clin Invest (1993) 1.59
The kinetics of electrical activity of beta cells in response to a "square wave" stimulation with glucose or glibenclamide. Horm Metab Res (1976) 1.55
Electrical characteristics of the beta-cells in pancreatic islets. J Physiol (Paris) (1976) 1.53
Phentolamine and yohimbine inhibit ATP-sensitive K+ channels in mouse pancreatic beta-cells. Br J Pharmacol (1990) 1.45
Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells. Diabetes (1994) 1.44
Tight links between adenine and guanine nucleotide pools in mouse pancreatic islets: a study with mycophenolic acid. Biochem J (1997) 1.43
The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets. J Biol Chem (1998) 1.39
Tolbutamide stimulation and inhibition of insulin release: studies of the underlying ionic mechanisms in isolated rat islets. Diabetologia (1980) 1.34
Uptake and release of Ca2+ by the endoplasmic reticulum contribute to the oscillations of the cytosolic Ca2+ concentration triggered by Ca2+ influx in the electrically excitable pancreatic B-cell. J Biol Chem (1999) 1.33
Pronase effect on pancreatic beta cell secretion and morphology. Science (1973) 1.31
The ionic, electrical, and secretory effects of endogenous cyclic adenosine monophosphate in mouse pancreatic B cells: studies with forskolin. Endocrinology (1984) 1.23
Influence of cell number on the characteristics and synchrony of Ca2+ oscillations in clusters of mouse pancreatic islet cells. J Physiol (1999) 1.22
Possible links between glucose-induced changes in the energy state of pancreatic B cells and insulin release. Unmasking by decreasing a stable pool of adenine nucleotides in mouse islets. J Clin Invest (1995) 1.21
Concentration dependence and time course of the effects of glucose on adenine and guanine nucleotides in mouse pancreatic islets. J Biol Chem (1996) 1.20
Effects of amino acids on membrane potential and 86Rb+ fluxes in pancreatic beta-cells. Am J Physiol (1981) 1.19
Stable and diffusible pools of nucleotides in pancreatic islet cells. Endocrinology (1996) 1.17
Effects of putative activators of K+ channels in mouse pancreatic beta-cells. Br J Pharmacol (1989) 1.17
Tetraethylammonium potentiation of insulin release and inhibition of rubidium efflux in pancreatic islets. Biochem Biophys Res Commun (1977) 1.17
Cobalt inhibition of insulin secretion and calcium uptake by isolated rat islets. Am J Physiol (1975) 1.17
Cyclic variations of glucose-induced electrical activity in pancreatic B cells. Pflugers Arch (1982) 1.17
Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli. Diabetes (1982) 1.15
Imidazoline antagonists of alpha 2-adrenoceptors increase insulin release in vitro by inhibiting ATP-sensitive K+ channels in pancreatic beta-cells. Br J Pharmacol (1992) 1.11
High incidence of hypoglycaemia in African patients treated with intravenous quinine for severe malaria. Br Med J (Clin Res Ed) (1987) 1.11
High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells. J Biol Chem (2001) 1.11
The ionic, electrical, and secretory effects of protein kinase C activation in mouse pancreatic B-cells: studies with a phorbol ester. Endocrinology (1987) 1.10
Quinine-induced modifications of insulin release and glucose metabolism by isolated pancreatic islets. FEBS Lett (1975) 1.10
Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits beta-cells and gradually increases the individual cell response. Diabetes (2001) 1.10
Emptying of intracellular Ca2+ stores stimulates Ca2+ entry in mouse pancreatic beta-cells by both direct and indirect mechanisms. J Physiol (1997) 1.10
Metabolic control of potassium permeability in pancreatic islet cells. Biochem J (1980) 1.07
Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications. Diabetologia (1987) 1.07
The influence of gamma-aminobutyric acid on hormone release by the mouse and rat endocrine pancreas. Endocrinology (1991) 1.06
Potassium dependence of the membrane potential of pancreatic B-cells. FEBS Lett (1978) 1.05
Glucagon immunoassay using polyethylene glycol to precipitate antibody-bound hormone. Diabetologia (1974) 1.04
Cell populations in the endocrine pancreas of human neonates and infants. Diabetologia (1981) 1.04
Diet- and diabetes-induced changes of ob gene expression in rat adipose tissue. FEBS Lett (1995) 1.03
Disorganization of cytoplasmic Ca(2+) oscillations and pulsatile insulin secretion in islets from ob/ obmice. Diabetologia (2002) 1.03
Distinct effects of glucose on the synchronous oscillations of insulin release and cytoplasmic Ca2+ concentration measured simultaneously in single mouse islets. Endocrinology (1995) 1.03
Phlorizin treatment of diabetic rats partially reverses the abnormal expression of genes involved in hepatic glucose metabolism. Diabetologia (1993) 1.02
Quinine and the stimulus-secretion coupling in pancreatic beta-cells: glucose-like effects on potassium permeability and insulin release. Endocrinology (1982) 1.02
The islet in type 2 diabetes: back to center stage. Diabetes (2001) 1.01
Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells. Biochem J (1994) 1.01
Temporal and quantitative correlations between insulin secretion and stably elevated or oscillatory cytoplasmic Ca2+ in mouse pancreatic beta-cells. Diabetes (1998) 1.01
Insulin release, cGMP, cAMP, and membrane potential in acetylcholine-stimulated islets. Am J Physiol (1978) 1.01
Oscillations of insulin secretion can be triggered by imposed oscillations of cytoplasmic Ca2+ or metabolism in normal mouse islets. Diabetes (1999) 1.00
The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose: in search of the underlying mechanism. Diabetes (1998) 0.99
Mechanism of the stimulation of insulin release in vitro by HB 699, a benzoic acid derivative similar to the non-sulphonylurea moiety of glibenclamide. Diabetologia (1985) 0.98
Effects of trifluoperazine and pimozide on stimulus-secretion coupling in pancreatic B-cells. Suggestion for a role of calmodulin? Biochem J (1981) 0.98
The role of protein kinase-C in signal transduction through vasopressin and acetylcholine receptors in pancreatic B-cells from normal mouse. Endocrinology (1994) 0.97
A single mechanism for the stimulation of insulin release and 86Rb+ efflux from rat islets by cationic amino acids. Biochem J (1982) 0.97
Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype. Diabetes (1999) 0.96
Forskolin, an activator of adenylate cyclase, increases CA2+-dependent electrical activity induced by glucose in mouse pancreatic B cells. Endocrinology (1983) 0.96
Glucose-induced changes of the membrane potential of pancreatic B-cells: their significance for the regulation of insulin release. Adv Exp Med Biol (1979) 0.95
Bicarbonate modulation of glucose-9nduced biphasic insulin release by rat islets. Am J Physiol (1976) 0.95
Dibutyryl cyclic AMP triggers Ca2+ influx and Ca2+-dependent electrical activity in pancreatic B cells. Biochem Biophys Res Commun (1983) 0.95
Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP. Diabetologia (2003) 0.95
9-Aminoacridine- and tetraethylammonium-induced reduction of the potassium permeability in pancreatic B-cells. Effects on insulin release and electrical properties. Biochim Biophys Acta (1979) 0.94
Glucose-, calcium- and concentration-dependence of acetylcholine stimulation of insulin release and ionic fluxes in mouse islets. Biochem J (1988) 0.94
The potassium permeability of pancreatic islet cells: mechanisms of control and influence on insulin release. Horm Metab Res Suppl (1980) 0.94
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med (1999) 0.94
Highly potent and stereoselective effects of the benzoic acid derivative AZ-DF 265 on pancreatic beta-cells. Br J Pharmacol (1988) 0.93
Distinct effects of acetylcholine and glucose on 45calcium and 86rubidium efflux from mouse pancreatic islets. FEBS Lett (1984) 0.93
Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose. Am J Physiol Endocrinol Metab (2004) 0.93
Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats. Endocrinology (1989) 0.92
Clonidine inhibits ATP-sensitive K+ channels in mouse pancreatic beta-cells. Br J Pharmacol (1991) 0.92
Electrogenic sodium pump in beta-cells of islets of Langerhans. J Physiol (1975) 0.92
Mechanisms of the stimulation of insulin release by arginine-vasopressin in normal mouse islets. J Biol Chem (1990) 0.92
The interplay between cyclic AMP and ions in the stimulus-secretion coupling in pancreatic B-cells. Arch Int Physiol Biochim (1985) 0.91
The role of metabolism, cytoplasmic Ca2+, and pH-regulating exchangers in glucose-induced rise of cytoplasmic pH in normal mouse pancreatic islets. J Biol Chem (1995) 0.90
Modulation of the effect of acetylcholine on insulin release by the membrane potential of B cells. Endocrinology (1987) 0.90
Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels. Br J Pharmacol (2010) 0.90
Oral selenate improves glucose homeostasis and partly reverses abnormal expression of liver glycolytic and gluconeogenic enzymes in diabetic rats. Diabetologia (1996) 0.90
Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells. Endocrinology (1999) 0.90
High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB. Diabetologia (2005) 0.89
Relative importance of extracellular and intracellular calcium for the two phases of glucose-stimulated insulin release: studies with theophylline. Endocrinology (1978) 0.89
Sulphonylureas do not increase insulin secretion by a mechanism other than a rise in cytoplasmic Ca2+ in pancreatic B-cells. Eur J Pharmacol (1996) 0.89
Cationic environment and dynamics of insulin secretion. III. Effect of the absence of potassium. Diabetologia (1974) 0.89
The electrical activity of pancreatic beta-cells of diabetic mice. FEBS Lett (1976) 0.89