Published in Proc Natl Acad Sci U S A on June 01, 1977
Two distinct adenosine-sensitive sites on adenylate cyclase. Proc Natl Acad Sci U S A (1977) 3.89
Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP. Biochem J (1978) 1.85
Interferon induction: a conformational hypothesis. Proc Natl Acad Sci U S A (1979) 0.75
Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity. Lancet (1972) 9.01
The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices. Mol Pharmacol (1970) 5.15
Modulation of inflammation and immunity by cyclic AMP. Science (1974) 4.31
Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am J Physiol (1963) 4.04
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action. J Biol Chem (1971) 3.52
The role of cyclic 3',5' adenosine monophosphate in the specific cytolytic activity of lymphocytes. J Immunol (1972) 3.51
Cellular hypersensitivity and immunity. Inhibition of macrophage migration and the lymphocyte mediators. Prog Allergy (1972) 3.47
Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells: role of adenosine deaminase. Science (1973) 2.37
Occurrence of malignancy in immunodeficiency diseases. A literature review. Cancer (1971) 2.31
Detection of the carrier state in combined immunodeficiency disease associated with adenosine deaminase deficiency. J Clin Invest (1974) 2.23
Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity. J Biol Chem (1976) 2.14
Potentiation of adenosine and the adenine nucleotides by dipyridamole. Br J Pharmacol Chemother (1966) 1.93
Adenosine inhibition of lymphocyte-mediated cytolysis: possible role of cyclic adenosine monophosphate. Science (1975) 1.92
Effects of adenosine on levels of adenosine cyclic 3',5'-monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation. Mol Pharmacol (1975) 1.84
Evidence for interdependent action of glucagon and nucleotides on the hepatic adenylate cyclase system. J Biol Chem (1974) 1.80
Variable effects of anti-lymphocyte serum on humoral antibody formation: role of thymus dependency of antigen. J Immunol (1971) 1.80
Studies on the lymphocyte 5'-nucleotidase in chronic lymphocytic leukemia, infectious mononucleosis, normal subpopulations, and phytohemagglutinin-stimulated cells. Cancer Res (1974) 1.74
Adenosine-deaminase deficiency and combined immunodeficiency syndrome. Lancet (1972) 1.62
Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate. J Biol Chem (1974) 1.61
Lethality of adenosine for cultured mammalian cells by interference with pyrimidine biosynthesis. J Cell Sci (1973) 1.55
Role of adenine nucleotides, adenosine, and inorganic phosphate in the regulation of skeletal muscle blood flow. Circ Res (1971) 1.55
Absence of erythrocyte adenosine deaminase associated with severe combined immunodeficiency. J Pediatr (1974) 1.46
The hepatic adenylate cyclase system. I. Evidence for transition states and structural requirements for guanine nucloetide activiation. J Biol Chem (1975) 1.43
Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis. J Clin Invest (1976) 1.36
Adenosine metabolism in phytohemagglutinin-stimulated human lymphocytes. J Clin Invest (1976) 1.29
Immunosuppression and cancer. Transplant Proc (1973) 1.26
Mouse neuroblastoma adenylate cyclase. Adenosine and adenosine analogues as potent effectors of adenylate cyclase activity. J Biol Chem (1975) 1.25
Regulation of adenosine 3':5'-monophosphate content in human astrocytoma cells by adenosine and the adenine nucleotides. J Biol Chem (1974) 1.24
Molecular form of adenosine deaminase in severe combined immunodeficiency. Biochem Biophys Res Commun (1974) 1.24
The effects of bases and nucleosides on the intracellular contents of nucleotides and 5-phosphoribosyl 1-pyrophosphate in Escherichia coli. Eur J Biochem (1974) 1.22
The potentiation of the action of adenosine on the guinea-pig heart. Biochem Pharmacol (1973) 1.20
Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemia cells. Cancer Res (1973) 1.20
Adenosine deaminase activity in leukaemia. Br J Cancer (1975) 1.19
Adenosine-elicited accumulation of cyclic AMP in brain slices: potentiation by agents which inhibit uptake of adenosine. Life Sci (1974) 1.17
Activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine. Life Sci II (1972) 1.17
Characterization of residual enzyme activity in fibroblasts from patients with adenosine deaminase deficiency and combined immunodeficiency: evidence for a mutant enzyme. Proc Natl Acad Sci U S A (1976) 1.15
The response of T cells to histocompatibility-2 antigens. Dose-response kinetics. J Exp Med (1972) 1.11
A normal level of adenosine deaminase activity in the red cell lysates of carriers and patients with severe combined immunodeficiency disease. Proc Natl Acad Sci U S A (1976) 1.07
The crystal structure of deoxyadenosine monohydrate. Acta Crystallogr (1965) 1.06
Adenosine metabolism in human erythrocytes. Biochim Biophys Acta (1971) 1.02
Cyclic nucleotides in disease; on the biochemical etiology of hypertension. Life Sci (1975) 1.01
Effects of adenine arabinoside on cellular immune mechanisms in humans. Antimicrob Agents Chemother (1975) 1.00
Synergy of 9-beta-D-arabinofuranosyladenine and human interferon against Herpes simplex virus, type 1. J Infect Dis (1974) 1.00
2-Fluoroadenosine 3':5'-monophosphate. A metabolite of 2-fluoroadenosine in mouse cytotoxic lymphocytes. J Biol Chem (1976) 0.99
Effect of adenosine on cyclic AMP accumulation in ventricular myocardium. Biochem Pharmacol (1976) 0.98
Cardiovascular effects of nucleoside analogs. Ann N Y Acad Sci (1975) 0.96
Regulation of adenylate cyclase from cultured human cell lines by adenosine. J Biol Chem (1976) 0.95
The adenosine-like effect of exogenous cyclic AMP upon nucleotide and PP-ribose-P concentrations of cultured human lymphoblasts. FEBS Lett (1976) 0.95
2-Alkylthioadenosines, specific coronary vasodilators. J Med Chem (1971) 0.95
Inhibition of phosphoribosylpyrophosphate synthesis by purine nucleosides in human erythrocytes. J Biol Chem (1976) 0.94
8-Alkylaminoadenyl nucleotides as probes of dehydrogenase interactions with nucleotide analogs of different glycosyl conformation. J Biol Chem (1976) 0.92
Decreased lymphocyte adenosine deaminase activity in acute lymphocytic leukemia children and their parents. Cancer Res (1975) 0.88
Incorporation of nucleosides into the nucleotide pools of human erythrocytes. Adenosine and its analogs. Biochemistry (1973) 0.87
Cholera toxin-peroxidase: changes in surface labeling of glioblastoma cells with increased time in tissue culture. Science (1976) 0.86
Failure of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) to stimllate interferon. Antimicrob Agents Chemother (1973) 0.85
Toxicity of 9-beta-D-arabinofuranosyladenine in mice and rabbits. Antimicrob Agents Chemother (Bethesda) (1968) 0.85
Regulation of adenylyl cyclase from isolated pancretic islets by prostaglandins and guanosine 5'-triphosphate. Biochemistry (1974) 0.84
Theoretical studies of the conformational properties of ribavirin. Proc Natl Acad Sci U S A (1976) 0.83
Cyclic AMP and immune responses: changes in the splenic level of cyclic AMP during the response of mice to antigen. Proc Natl Acad Sci U S A (1975) 0.83
Selective immunosuppression by drugs in balanced immune responses. Fed Proc (1974) 0.82
Drugs used in the treatment of cancer. FEBS Lett (1975) 0.81
Synthesis and coronary vasodilating activity of 2-substituted adenosines. Chem Pharm Bull (Tokyo) (1975) 0.81
Formation of adenosine 3',5'-monophosphate from adenosine in mouse thymocytes. Biochim Biophys Acta (1975) 0.81
Inhibition of 5'-nucleotidase in rat brain by methylxanthines. J Neurochem (1975) 0.80
Studies on immunosuppression by purine nucleoside analogues. I. Effects on the immune response to sheep red blood cells in mice. Biochem Pharmacol (1969) 0.79
Regulation of purine nucleotide synthesis. Effects of inosine on normal and hypoxantine-guanine phosphoribosyltransferase-deficient fibroblasts. Biochim Biophys Acta (1976) 0.78
Separation of vasodilator and negative chronotropic actions in analogues of adenosine. Eur J Pharmacol (1972) 0.78
Evidence from the control of pyrimidine biosynthesis in tissue minces by purines. Biochem Biophys Res Commun (1974) 0.78
Inhibitor of pyrimidine metabolism from tumor tissues. Biochem Biophys Res Commun (1973) 0.76
Relation of structure of purine and pyrimidine nucleosides to antitumor activity. Cancer Chemother Rep 2 (1968) 0.76
Biotransformation of 9-beta-D-arabinofurano-syladenine by rat and human erythrocytes. Biochem Pharmacol (1974) 0.76
Control of pyrimidine biosynthesis in human lymphocytes. Inhibition of pyrimidine biosynthesis de novo in phytohemagglutinin-stimulated lymphocytes by external uridine and its inhibition mechanism. J Biol Chem (1973) 0.76
Disposition and metabolism of thiopurines. II. Arabinosyl-6-mercaptopurine and ribosyl-6-mercaptopurine. Drug Metab Dispos (1974) 0.76
SIGNIFICANT STRUCTURES IN LIQUIDS, III. PARTITION FUNCTION FOR FUSED SALTS. Proc Natl Acad Sci U S A (1960) 5.53
SIGNIFICANT STRUCTURES IN LIQUIDS. II. Proc Natl Acad Sci U S A (1959) 5.00
Prevention of denervation in Bell's palsy. Br Med J (1966) 4.76
Application of the singular perturbation method to reaction kinetics. Proc Natl Acad Sci U S A (1973) 4.05
SIGNIFICANT STRUCTURES IN LIQUIDS, V. THERMODYNAMIC AND TRANSPORT PROPERTIES OF MOLTEN METALS. Proc Natl Acad Sci U S A (1960) 3.12
AN APPROXIMATE CELL MODEL FOR LIQUID HYDROGEN, I. Proc Natl Acad Sci U S A (1962) 2.59
THE SIGNIFICANT STRUCTURE THEORY APPLIED TO META- AND PARA-XYLENE. Proc Natl Acad Sci U S A (1965) 2.45
Reconstitution of interleukin 2 with albumin for infusion. Lancet (1990) 2.37
Nitric oxide synthase activity in human breast cancer. Br J Cancer (1995) 2.22
SIGNIFICANT LIQUID STRUCTURE THEORY, IX. PROPERTIES OF DENSE GASES AND LIQUIDS. Proc Natl Acad Sci U S A (1962) 2.12
Kinetics of heterogeneous chemical reactions. II. Proc Natl Acad Sci U S A (1970) 2.04
Magnetic circular dichroism of molecules in dense media: benzene. Proc Natl Acad Sci U S A (1972) 2.01
The dynamics of life. I. Death from internal irradiation by 239Pu and 226Ra, aging, cancer, and other diseases. Proc Natl Acad Sci U S A (1970) 1.95
Significant structure theory applied to liquid helium-3. Proc Natl Acad Sci U S A (1977) 1.90
A general treatment of relaxation phenomena. Proc Natl Acad Sci U S A (1977) 1.78
SIGNIFICANT STRUCTURES IN LIQUIDS, IV. LIQUID CHLORINE. Proc Natl Acad Sci U S A (1960) 1.77
The dynamics of life. II. The steady-state theory of mutation rates. Proc Natl Acad Sci U S A (1970) 1.74
The dynamics of life, 3. Mechanisms of nonsurvival and the relation of dose size. Proc Natl Acad Sci U S A (1970) 1.70
Evidence for a feedback inhibition of insulin on insulin secretion in the isolated, perfused canine pancreas. Diabetes (1971) 1.70
Collisional energy transfer and quenching of electronic excitation. Proc Natl Acad Sci U S A (1975) 1.68
Activity of type IV collagenases in benign and malignant breast disease. Br J Cancer (1993) 1.68
The Mechanical Properties of Rat Tail Tendon. J Gen Physiol (1959) 1.65
Role of nitric oxide in tumour progression: lessons from human tumours. Cancer Metastasis Rev (1998) 1.61
Galvanic stimulation of the tongue as a prognostic index in Bell's palsy. Br Med J (1965) 1.60
SIGNIFICANT STRUCTURE THEORY OF BINARY LIQUID MIXTURES: CARBON TETRACHLORIDE AND CYCLOHEXANE. Proc Natl Acad Sci U S A (1964) 1.60
MUC1 and cancer. Biochim Biophys Acta (1999) 1.60
Absolute Rate Theory for Isolated Systems and the Mass Spectra of Polyatomic Molecules. Proc Natl Acad Sci U S A (1952) 1.58
The relation between social class and functional status: a new look at the drift hypothesis. J Health Soc Behav (1976) 1.55
The dynamics of life: aging. Proc Natl Acad Sci U S A (1972) 1.49
The dielectric constant of liquid water and various forms of ice according to significant structure theory. Proc Natl Acad Sci U S A (1966) 1.49
Radioimmunoassay for urinary albumin using a single antibody. Scand J Clin Lab Invest (1970) 1.43
STRAIN ELECTROMETRY AND CORROSION I. GENERAL CONSIDERATIONS ON INTERFACIAL ELECTRICAL TRANSIENTS. Proc Natl Acad Sci U S A (1957) 1.39
THE INACTIVATION OF GROWTH-PROMOTING DISLOCATIONS WITH TEMPERATURE, PRESSURE, AND POISONS. Proc Natl Acad Sci U S A (1958) 1.39
Study of vibronic and born-oppenheimer couplings. Proc Natl Acad Sci U S A (1974) 1.38
Single partition function for three phases. Proc Natl Acad Sci U S A (1977) 1.37
Significant structure theory applied to liquid He. Proc Natl Acad Sci U S A (1980) 1.36
The dynamics of life. V. Applying the steady-state theory of mutations to human cancer. Proc Natl Acad Sci U S A (1971) 1.34
THE APPLICATION OF SIGNIFICANT STRUCTURE THEORY TO BINARY LIQUID MIXTURES: AR + N(2), AR + O(2), AND O(2) + N(2). Proc Natl Acad Sci U S A (1965) 1.22
Different patterns of inflammation and prognosis in invasive carcinoma of the breast. Histopathology (2006) 1.19
Optical rotatory dispersion, circular dichroism, and absorption studies on some naturally occurring ribonucleosides and related derivatives. Proc Natl Acad Sci U S A (1967) 1.17
Retention of the expression of E-cadherin and catenins is associated with shorter survival in grade III ductal carcinoma of the breast. J Pathol (2001) 1.16
Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin. Immunology (1999) 1.16
A molecular mechanism of general anesthesia. Anesthesiology (1973) 1.15
Molecular mechanism of inhibition of firefly luminescence by local anesthetics. Proc Natl Acad Sci U S A (1976) 1.14
Overexpression of c-erbB2 is an independent marker of resistance to endocrine therapy in advanced breast cancer. Br J Cancer (1999) 1.14
Enhancing the effect of THERATOPE STn-KLH cancer vaccine in patients with metastatic breast cancer by pretreatment with low-dose intravenous cyclophosphamide. J Immunother Emphasis Tumor Immunol (1996) 1.13
Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy. Ann Oncol (2001) 1.12
Starvation kinetics. Science (1978) 1.12
A study of physicians' assistants in a rural setting. Med Care (1976) 1.11
Medium-induced radiationless transitions and effect of solvent on radiationless transitions. Proc Natl Acad Sci U S A (1976) 1.08
Properties of molten magnesium oxide. Proc Natl Acad Sci U S A (1975) 1.08
The significant structure theory applied to amorphous and crystalline polyethylene. Proc Natl Acad Sci U S A (1974) 1.08
Toxicity and reconstitution of recombinant interleukin-2 with albumin. Lancet (1991) 1.07
Antagonism between high pressure and anesthetics in the thermal phase-transition of dipalmitoyl phosphatidylcholine bilayer. Biochim Biophys Acta (1979) 1.07
Significant structure theory of surface tension of the alkali metals. Proc Natl Acad Sci U S A (1972) 1.06
Significant structure theory of molecules having hindered intermolecular rotation in the condensed phases. Proc Natl Acad Sci U S A (1966) 1.06
Circular dichroism of nucleoside derivatives. IV. Uracil derivatives. J Am Chem Soc (1969) 1.04
Optical and conformational properties of the 7-(beta-D-ribofuranosyl)purines. Biopolymers (1972) 1.03
Circular dichroism of nucleoside derivatives. IX. Vicinal effects on the circular dichroism of pyrimidine nucleosides. J Am Chem Soc (1970) 1.01
On an improved partition function of significant structure theory. Proc Natl Acad Sci U S A (1967) 1.01
The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breast tissue. J Pathol (1997) 1.00
Circular dichroism of nucleoside derivatives. V. Cytosine derivatives. J Am Chem Soc (1969) 1.00
Family history and survival in premenopausal breast cancer. Br J Cancer (1998) 0.99
Biological electron transport. II. A variation of the imidazole pump model to include coupling. J Theor Biol (1965) 0.99
Untangling biological reactions. Science (1966) 0.99
Multiple prescriptions and drug appropriateness. Health Serv Res (1977) 0.96
On the density matrix approach of intramolecular relaxation processes. Proc Natl Acad Sci U S A (1981) 0.96
Ion flow through a membrane: concentration and current responses to a step potential change. Proc Natl Acad Sci U S A (1978) 0.96
Comparative study by circular dichroism of the conformation of deazapurine nucleosides and that of common purine nucleosides. Proc Natl Acad Sci U S A (1976) 0.96
Vicinal effects on the optical activity of some adenine nucleosides. J Phys Chem (1968) 0.96
Significant structure theory of isotope effect. Proc Natl Acad Sci U S A (1967) 0.95
Reciprocal relations and proximity of bases in falvin-adenine dinucleotide. Biochemistry (1968) 0.92
Randomized phase II non-inferiority study (NO16853) of two different doses of capecitabine in combination with docetaxel for locally advanced/metastatic breast cancer. Ann Oncol (2011) 0.90
Configuration Interaction in the Calculation of Oscillatory and Rotatory Intensities of Nonplanar pi-Electronic Systems. Proc Natl Acad Sci U S A (1970) 0.90
Circular dichroism of nucleoside derivatives. VI. The optically active bands of adenine nucleoside derivatives. Proc Natl Acad Sci U S A (1969) 0.90
Bevacizumab in combination with taxanes for the first-line treatment of metastatic breast cancer. Ann Oncol (2010) 0.90
Mitomycin, ifosfamide and cisplatin in non-small-cell lung cancer. Cancer Chemother Pharmacol (1990) 0.89
Reciprocal relations in the circular dichroism of adenosine mononicotinate. J Phys Chem (1967) 0.89
Nuclear magnetic resonance studies of the interaction of general anesthetics with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholine bilayer. Proc Natl Acad Sci U S A (1976) 0.89
Circular dichroism of nucleoside derivatives. X. Influence of solvents and substituents upon the Cotton effects of guanosine derivatives. J Am Chem Soc (1971) 0.89
13. New biological therapies for breast cancer. Int J Clin Pract (2002) 0.89
Hydrostatic pressure and ionic strength effects on the kinetics of lysozyme. Proc Natl Acad Sci U S A (1972) 0.87
The significant structure theory applied to liquid oxygen. Proc Natl Acad Sci U S A (1967) 0.87
A conformational basis for the selective action of ara-adenine. J Theor Biol (1977) 0.86
Sensitivity and reliability of the senses. Proc Natl Acad Sci U S A (1967) 0.86
Reciprocal relations and proximity of bases in pyridine dinucleotides. J Biol Chem (1968) 0.86
Biological electron transport. I. Imidazole pump model of electron transport: a group transfer model. J Theor Biol (1965) 0.86
Chemical Valence Forces and Binding Energy Calculations. Proc Natl Acad Sci U S A (1952) 0.85