Subunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 26792524)

Published in Proc Natl Acad Sci U S A on January 20, 2016

Authors

Nurit Degani-Katzav1, Revital Gortler1, Lilach Gorodetzki1, Yoav Paas2

Author Affiliations

1: Laboratory of Ion Channels, The Mina and Everard Goodman Faculty of Life Sciences and The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 52900, Israel.
2: Laboratory of Ion Channels, The Mina and Everard Goodman Faculty of Life Sciences and The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 52900, Israel yoav.paas@biu.ac.il.

Articles cited by this

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. J Mol Biol (1965) 46.35

Sodium and calcium channels in bovine chromaffin cells. J Physiol (1982) 12.64

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature (2001) 11.78

The SWISS-MODEL Repository and associated resources. Nucleic Acids Res (2008) 11.61

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron (2004) 7.48

Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature (2011) 5.93

Emerging structure of the nicotinic acetylcholine receptors. Nat Rev Neurosci (2002) 5.87

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature (2008) 5.77

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J (2005) 5.55

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel. Nature (2008) 5.09

International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev (2008) 4.49

Recent advances in Cys-loop receptor structure and function. Nature (2006) 4.20

On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine. J Theor Biol (1967) 4.15

Cys-loop receptors: new twists and turns. Trends Neurosci (2004) 3.58

Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors. Mol Pharmacol (2003) 3.22

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature (1994) 2.92

Ivermectin 20 years on: maturation of a wonder drug. Trends Parasitol (2005) 2.90

Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature (2003) 2.89

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel. Nature (2004) 2.77

avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans. EMBO J (1997) 2.55

The structural basis of function in Cys-loop receptors. Q Rev Biophys (2010) 2.45

alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol Pharmacol (2006) 2.42

Crystal structure of a human GABAA receptor. Nature (2014) 2.22

Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor. Neuron (1999) 2.08

Characteristics of sodium and calcium conductance changes produced by membrane depolarization in an Aplysia neurone. J Physiol (1979) 2.06

Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker. J Gen Physiol (2007) 1.98

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. EMBO J (2009) 1.91

The extracellular linker of muscle acetylcholine receptor channels is a gating control element. J Gen Physiol (2000) 1.74

Actions of genistein on cystic fibrosis transmembrane conductance regulator channel gating. Evidence for two binding sites with opposite effects. J Gen Physiol (1998) 1.74

Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels. J Neurosci (2002) 1.71

Glycine receptors: recent insights into their structural organization and functional diversity. J Neurochem (2006) 1.61

Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine. Biophys J (1999) 1.57

Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors. J Neurosci (2011) 1.56

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proc Natl Acad Sci U S A (2011) 1.52

The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization. J Neurosci (2008) 1.40

Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity. J Biol Chem (2011) 1.39

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proc Natl Acad Sci U S A (2012) 1.38

A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors. J Neurosci (2005) 1.33

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine. Nat Commun (2012) 1.26

Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel. FEBS Lett (2002) 1.25

Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions. J Neurosci (2009) 1.25

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci U S A (2012) 1.22

Structural mechanisms underlying benzodiazepine modulation of the GABA(A) receptor. J Neurosci (2008) 1.20

Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization. J Biol Chem (1997) 1.20

Allosteric receptors: from electric organ to cognition. Annu Rev Pharmacol Toxicol (2010) 1.19

The role of the cystine loop in acetylcholine receptor assembly. J Biol Chem (1997) 1.17

Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. J Biol Chem (2009) 1.16

Thinking in cycles: MWC is a good model for acetylcholine receptor-channels. J Physiol (2011) 1.13

Picrotoxin blockade of invertebrate glutamate-gated chloride channels: subunit dependence and evidence for binding within the pore. J Neurochem (1999) 1.12

Stoichiometry of the alpha9alpha10 nicotinic cholinergic receptor. J Neurosci (2005) 1.11

Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells. PLoS One (2010) 1.09

Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi. Proc Natl Acad Sci U S A (2010) 1.08

Actions of the anthelmintic ivermectin on the pharyngeal muscle of the parasitic nematode, Ascaris suum. Parasitology (1997) 1.05

A functional model for G protein activation of the muscarinic K+ channel in guinea pig atrial myocytes. Spectral analysis of the effect of GTP on single-channel kinetics. J Gen Physiol (1996) 1.04

An amino acid substitution in the pore region of a glutamate-gated chloride channel enables the coupling of ligand binding to channel gating. J Biol Chem (1996) 1.03

Identification of two amino acid residues in the epsilon subunit that promote mammalian muscle acetylcholine receptor assembly in COS cells. Neuron (1991) 1.01

Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes. Biochem Pharmacol (2007) 1.00

Caenorhabditis elegans ivermectin receptors regulate locomotor behaviour and are functional orthologues of Haemonchus contortus receptors. Mol Biochem Parasitol (2006) 0.99

Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy. J Biol Chem (2009) 0.99

Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin. Front Mol Neurosci (2012) 0.98

Ivermectin, 'wonder drug' from Japan: the human use perspective. Proc Jpn Acad Ser B Phys Biol Sci (2011) 0.96

Stoichiometry of expressed alpha(4)beta(2)delta gamma-aminobutyric acid type A receptors depends on the ratio of subunit cDNA transfected. J Biol Chem (2010) 0.96

Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes. Circ Res (1995) 0.96

Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor. Neuron (1995) 0.95

Monod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate. Curr Opin Anaesthesiol (2012) 0.92

Allosteric proteins after thirty years: the binding and state functions of the neuronal alpha 7 nicotinic acetylcholine receptors. Experientia (1996) 0.90

Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor. Neuropharmacology (2010) 0.90

Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin. Biophys J (2013) 0.90

History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents. Curr Pharm Biotechnol (2012) 0.88

Mechanisms for picrotoxin block of alpha2 homomeric glycine receptors. J Biol Chem (2005) 0.88

Molecular dissection of Cl--selective Cys-loop receptor points to components that are dispensable or essential for channel activity. J Biol Chem (2011) 0.87

Probing protein packing surrounding the residues in and flanking the nicotinic acetylcholine receptor M2M3 loop. J Neurosci (2009) 0.86

An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin. J Biol Chem (2013) 0.82

Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface. Neuropharmacology (2015) 0.82

Functional evaluation of key interactions evident in the structure of the eukaryotic Cys-loop receptor GluCl. ACS Chem Biol (2014) 0.82

Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation. J Biol Chem (2010) 0.79