Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics.

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Published in Oncotarget on March 08, 2016

Authors

Deyao Xie1,2, Xiaoyi Wu2, Linhua Lan2, Fugeng Shangguan2, Xiaoming Lin1, Fuhong Chen2, Shan Xu2,3, Ya Zhang2, Zilei Chen2, Kate Huang4, Rongrong Wang4, Lu Wang2, Xiaoxiao Song5, Yongzhang Liu2, Bin Lu2

Author Affiliations

1: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
2: Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
3: Huzhou Health School, Huzhou, Zhejiang 313100, P.R. China.
4: Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
5: Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.

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