Published in Cell Mol Life Sci on June 20, 2014
The interplay between DNA repair and autophagy in cancer therapy. Cancer Biol Ther (2015) 0.89
Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform. Mutagenesis (2015) 0.87
Oxidative stress, bone marrow failure, and genome instability in hematopoietic stem cells. Int J Mol Sci (2015) 0.85
Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage. J Mol Cell Biol (2015) 0.85
Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress. Biochem Biophys Res Commun (2015) 0.84
ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses. Philos Trans R Soc Lond B Biol Sci (2017) 0.79
WWOX modulates the ATR-mediated DNA damage checkpoint response. Oncotarget (2016) 0.79
REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts. Biochem Biophys Res Commun (2015) 0.77
Cell-free Xenopus egg extracts for studying DNA damage response pathways. Int J Dev Biol (2016) 0.76
Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics. Oncotarget (2016) 0.76
7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells. Oncotarget (2016) 0.75
PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells. Biomed Res Int (2017) 0.75
Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response. World J Virol (2015) 0.75
Transcriptional profile of HIV-induced nuclear translocation of amyloid β in brain endothelial cells. Arch Med Res (2014) 0.75
APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress. Proc Natl Acad Sci U S A (2016) 0.75
Acetylation of hMOF Modulates H4K16ac to Regulate DNA Repair Genes in Response to Oxidative Stress. Int J Biol Sci (2017) 0.75
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
Instability and decay of the primary structure of DNA. Nature (1993) 25.58
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11
The DNA damage response: putting checkpoints in perspective. Nature (2000) 19.07
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
The DNA-damage response in human biology and disease. Nature (2009) 17.86
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A (1993) 13.27
Cell-cycle checkpoints and cancer. Nature (2004) 13.19
Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
The DNA damage response: ten years after. Mol Cell (2007) 11.80
5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer (2003) 11.78
DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet (2001) 10.77
Human CtIP promotes DNA end resection. Nature (2007) 10.63
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov (2005) 9.47
Mechanism of eukaryotic homologous recombination. Annu Rev Biochem (2008) 8.86
ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem (2001) 8.78
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science (2005) 8.77
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science (1997) 8.24
ATR and ATRIP: partners in checkpoint signaling. Science (2001) 7.58
DNA damage, aging, and cancer. N Engl J Med (2009) 7.56
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem (2001) 7.35
Double-strand break end resection and repair pathway choice. Annu Rev Genet (2011) 7.31
ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev (2000) 7.28
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol (2001) 7.26
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol (2000) 7.26
Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet (2001) 6.77
DNA damage and repair. Nature (2003) 6.76
DNA repair pathways as targets for cancer therapy. Nat Rev Cancer (2008) 6.69
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol (2008) 6.62
TopBP1 activates the ATR-ATRIP complex. Cell (2006) 6.29
Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23
Oxidative stress: oxidants and antioxidants. Exp Physiol (1997) 6.12
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet (2003) 6.03
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol (2007) 5.78
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
ATM activation by oxidative stress. Science (2010) 5.22
Checking on DNA damage in S phase. Nat Rev Mol Cell Biol (2004) 4.91
Redefining oxidative stress. Antioxid Redox Signal (2006) 4.71
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol (2005) 4.62
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science (2004) 4.58
MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature (2003) 4.56
Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet (2006) 4.42
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature (2009) 4.30
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev (2001) 4.28
Replication checkpoint enforced by kinases Cds1 and Chk1. Science (1998) 4.22
Initiating cellular stress responses. Cell (2004) 4.18
Single-strand break repair and genetic disease. Nat Rev Genet (2008) 4.07
Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol (1994) 4.04
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev (2000) 3.96
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene (2007) 3.68
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell (2000) 3.65
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev (2007) 3.58
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
The structural determinants of checkpoint activation. Genes Dev (2007) 3.53
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci U S A (1996) 3.31
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol (2003) 3.29
Activation of the cellular DNA damage response in the absence of DNA lesions. Science (2008) 3.17
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem Cell Biol (2007) 3.13
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science (2001) 3.13
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell (2009) 3.12
Profiling of UV-induced ATM/ATR signaling pathways. Proc Natl Acad Sci U S A (2007) 3.12
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J (2006) 3.05
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A (2010) 3.03
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev (2008) 2.86
H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc Natl Acad Sci U S A (2006) 2.85
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc Natl Acad Sci U S A (2003) 2.80
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell (2004) 2.75
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell (2006) 2.73
DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer (2012) 2.70
The interacting pathways for prevention and repair of oxidative DNA damage. Mutat Res (2003) 2.63
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products. Chem Res Toxicol (2006) 2.62
The mismatch repair system is required for S-phase checkpoint activation. Nat Genet (2002) 2.55
Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex. DNA Repair (Amst) (2004) 2.55
The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol Cell Biol (2007) 2.54
Mismatch repair and DNA damage signalling. DNA Repair (Amst) (2004) 2.47
Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst) (2005) 2.46
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem (2007) 2.31
ATM regulates ATR chromatin loading in response to DNA double-strand breaks. J Exp Med (2006) 2.31
ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair (Amst) (2002) 2.30
Coupling of human circadian and cell cycles by the timeless protein. Mol Cell Biol (2005) 2.24
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev (2004) 2.20
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer (2012) 2.20
DNA damage responses to oxidative stress. DNA Repair (Amst) (2004) 2.17
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev (2012) 2.16
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev (2004) 2.16
CtIP links DNA double-strand break sensing to resection. Mol Cell (2009) 2.11
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem (2003) 2.09
Human claspin is required for replication checkpoint control. J Biol Chem (2003) 2.02
Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions. J Biol Chem (2006) 2.00
Imaging metastasis using an integrin-targeting chain-shaped nanoparticle. ACS Nano (2012) 1.03
Multimodal in vivo imaging exposes the voyage of nanoparticles in tumor microcirculation. ACS Nano (2013) 0.88