Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression.

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Published in J Biol Chem on February 03, 2016

Authors

Christopher J Coke1, Kisha A Scarlett1, Mahandranauth A Chetram2, Kia J Jones1, Brittney J Sandifer1, Ahriea S Davis1, Adam I Marcus3, Cimona V Hinton4

Author Affiliations

1: From the Department of Biological Sciences and the Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, Georgia 30314.
2: Molecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D. C. 20057, and.
3: Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia 30322.
4: From the Department of Biological Sciences and the Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, Georgia 30314, chinton@cau.edu.

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Seven-transmembrane receptors. Nat Rev Mol Cell Biol (2002) 11.50

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International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev (2002) 8.50

Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature (1997) 6.23

Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell (2005) 6.04

Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther (1997) 5.20

G protein-coupled receptor allosterism and complexing. Pharmacol Rev (2002) 5.01

Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res (2002) 5.00

Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics (1995) 3.60

Chemokine receptors: gateways to inflammation and infection. Nat Med (1996) 3.56

Roles of G-protein-coupled receptor dimerization. EMBO Rep (2004) 3.33

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay. Methods (2008) 3.16

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. J Neurosci (2000) 2.90

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CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clin Cancer Res (2011) 2.39

Chemoattractant signaling and leukocyte activation. Blood (1995) 2.33

A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma. J Immunol (2001) 2.33

Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7. J Biol Chem (2004) 2.31

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Heterodimerization of g protein-coupled receptors: specificity and functional significance. Pharmacol Rev (2005) 2.25

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nat Chem Biol (2010) 2.15

Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J Biol Chem (1998) 2.02

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Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma. Breast Cancer Res (2003) 1.99

Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization. J Biol Chem (1997) 1.98

Ligand stabilization of CXCR4/delta-opioid receptor heterodimers reveals a mechanism for immune response regulation. Eur J Immunol (2008) 1.97

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Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J (2001) 1.94

Chemokines, inflammation and the immune system. Ther Immunol (1994) 1.86

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The pro-inflammatory seven-transmembrane segment receptors of the leukocyte. Curr Opin Immunol (1994) 1.47

Allosteric modulation of binding properties between units of chemokine receptor homo- and hetero-oligomers. Mol Pharmacol (2006) 1.47

Cannabinoids for cancer treatment: progress and promise. Cancer Res (2008) 1.46

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Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers. J Biol Chem (2007) 1.45

Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes. Mol Pharmacol (1985) 1.44

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Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds. Life Sci (1984) 0.80

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