A Perspective of Immunotherapy for Prostate Cancer.

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Published in Cancers (Basel) on July 07, 2016

Authors

Ida Silvestri1, Susanna Cattarino2, Sabrina Giantulli3, Cristina Nazzari4, Giulia Collalti5, Alessandro Sciarra6

Author Affiliations

1: Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy. ida.silvestri@uniroma1.it.
2: Department of Urology, Sapienza University of Rome, Rome 00161, Italy. susanna.cattarino@uniroma1.it.
3: Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy. sabrinagiantulli@alice.it.
4: Department of Public Health hand Infectious Diseases, "Sapienza" University of Rome, Rome 00185, Italy. cristina.nazzari@uniroma1.it.
5: Medicine of Systems, Rheumatology, Allergology and Clinical Immunology, Translational Medicine of the University Tor Vergata, Rome 00133, Italy. giulia.collalti86@gmail.com.
6: Department of Urology, Sapienza University of Rome, Rome 00161, Italy. sciarra.md@libero.it.

Associated clinical trials:

A Randomized, Double-blind, Phase 3 Efficacy Trial of PROSTVAC-V/F +/- GM-CSF in Men With Asymptomatic or Minimally Symptomatic Metastatic Castrate-Resistant Prostate Cancer (Prospect) | NCT01322490

Sipuleucel-T, CT-011, and Cyclophosphamide for Advanced Prostate Cancer | NCT01420965

Concurrent Versus Sequential Treatment With Sipuleucel-T and Abiraterone in Men With Metastatic Castrate Resistant Prostate Cancer (mCRPC) | NCT01487863

A Randomized Phase 2 Trial of Combining Sipuleucel-T With Immediate vs. Delayed CTLA-4 Blockade for Prostate Cancer | NCT01804465

A Study of Tasquinimod in Men With Metastatic Castrate Resistant Prostate Cancer | NCT01234311

Vaccine Therapy With PROSTVAC/TRICOM and Flutamide Versus Flutamide Alone to Treat Prostate Cancer | NCT00450463

Ipilimumab + Androgen Deprivation Therapy in Prostate Cancer | NCT01377389

Adoptive Transfer of Autologous T Cells Targeted to Prostate Specific Membrane Antigen (PSMA) for the Treatment of Castrate Metastatic Prostate Cancer (CMPC) | NCT01140373

Sipuleucel-T and Ipilimumab for Advanced Prostate Cancer | NCT01832870

Ipilimumab in Combination With Androgen Suppression Therapy in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer | NCT01498978

Phase II Study of Sipuleucel-T and Indoximod for Patients With Refractory Metastatic Prostate Cancer | NCT01560923

Combining Ipilimumab With Abiraterone Acetate Plus Prednisone in Chemotherapy and Immunotherapy-naïve Patients With Progressive Metastatic Castration-resistant Prostate Cancer | NCT01688492

Phase II PAP Plus GM-CSF Versus GM-CSF Alone for Non-metastatic Prostate Cancer | NCT01341652

Enzalutamide in Combination With PSA-TRICOM in Patients With Non-Metastatic Castration Sensitive Prostate Cancer | NCT01875250

Ipilimumab and Sargramostim in Treating Patients With Metastatic Prostate Cancer | NCT00064129

A Study of Sipuleucel-T With Administration of Enzalutamide in Men With Metastatic Castrate-Resistant Prostate Cancer | NCT01981122

Provenge With or Without pTVG-HP DNA Booster Vaccine in Prostate Cancer | NCT01706458

The CATCH Prostate Cancer Trial: Cabazitaxel And Tasquinimod in Men With Prostate Cancer (CATCH) | NCT01513733

A Neoadjuvant Study of Androgen Ablation Combined With Cyclophosphamide and GVAX Vaccine for Localized Prostate Cancer | NCT01696877

Sipuleucel-T With or Without Radiation Therapy in Treating Patients With Hormone-Resistant Metastatic Prostate Cancer | NCT01807065

CYT107 After Vaccine Treatment (Provenge) in Patients With Metastatic Hormone-Resistant Prostate Cancer | NCT01881867

Biomarker-Driven Therapy With Nivolumab and Ipilimumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Expressing AR-V7 (STARVE-PC) | NCT02601014

Sipuleucel-T and Stereotactic Ablative Body Radiation (SABR) for Metastatic Castrate-resistant Prostate Cancer (mCRPC) | NCT01818986

Phase III Study of DCVAC Added to Standard Chemotherapy for Men With Metastatic Castration Resistant Prostate Cancer (VIABLE) | NCT02111577

Safety and Efficacy Study of Ipilimumab 3 mg/kg Versus Ipilimumab 10 mg/kg in Subjects With Metastatic Castration Resistant Prostate Cancer Who Are Chemotherapy Naive | NCT02279862

Sipuleucel-T With or Without Tasquinimod in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer | NCT02159950

Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC | NCT02463799

Neoadjuvant PROSTVAC-VF With or Without Ipilimumab for Prostate Cancer | NCT02506114

A Phase 1/2 Study of In Situ Vaccination With Tremelimumab and IV Durvalumab Plus PolyICLC in Subjects With Advanced, Measurable, Biopsy-accessible Cancers | NCT02643303

T-Cell Responses to Neoantigens Post Treatment With Ipilimumab in Men With Metastatic Castration-Resistant Prostate Cancer | NCT02113657

Combining Ipilimumab, Degarelix, and Radical Prostatectomy in Men With Newly Diagnosed Metastatic Castration Sensitive Prostate Cancer or Ipilimumab and Degarelix in Men With Biochemically Recurrent Castration Sensitive Prostate Cancer After Radical Prostatectomy | NCT02020070

Dendreon Lymph Node Biopsy in Metastatic Castrate-Resistant Prostate Cancer | NCT02036918

Vaccine Plus Booster Shots in Men With Prostate Cancer Undergoing Treatment With Radical Prostatectomy | NCT02153918

PROSTVAC (PSA-TRICOM) in Preventing Disease Progression in Patients With Localized Prostate Cancer Undergoing Active Surveillance | NCT02326805

A Phase 1 Study To Evaluate Escalating Doses Of A Vaccine-Based Immunotherapy Regimen For Prostate Cancer (PrCa VBIR) | NCT02616185

A Multicenter Trial Enrolling Men With Advanced Prostate Cancer Who Are to Receive Combination Radiation and Sipuleucel-T | NCT02232230

Phase I Clinical Trial of Cryoimmunotherapy Against Prostate Cancer (CryoIT) | NCT02423928

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