Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.

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Published in Nat Rev Microbiol on May 01, 2009

Authors

Ronald S Flannagan1, Gabriela Cosío, Sergio Grinstein

Author Affiliations

1: Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature (2002) 7.53

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J (2000) 7.48

Endocytosis. Physiol Rev (1997) 7.33

The mannose 6-phosphate receptor and the biogenesis of lysosomes. Cell (1988) 7.22

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Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol (2004) 6.33

E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells. Cell (1996) 5.82

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A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J Cell Biol (1996) 5.52

Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3. J Immunol (1990) 5.39

Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol (1993) 5.36

Lactoferrin, an iron-binding protein in neutrophilic leukocytes. J Exp Med (1969) 5.12

Fc receptor biology. Annu Rev Immunol (1997) 5.08

Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine. J Exp Med (2001) 5.06

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Toll-like receptors control autophagy. EMBO J (2008) 4.50

A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science (2002) 4.49

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus. J Cell Biol (1994) 4.26

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells. Nat Rev Microbiol (2008) 4.09

The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread. Infect Immun (1995) 4.02

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FYVE fingers bind PtdIns(3)P. Nature (1998) 3.91

Biochemical stratagem for obligate parasitism of eukaryotic cells by Coxiella burnetii. Proc Natl Acad Sci U S A (1981) 3.91

Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature (2007) 3.81

Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors. J Exp Med (1987) 3.78

Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis. Infect Immun (1996) 3.67

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Mammalian nitric oxide synthases. Biochim Biophys Acta (1999) 3.55

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An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes. J Cell Biol (1996) 2.94

Ammonia inhibits phagosome-lysosome fusion in macrophages. Nature (1980) 2.89

Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturation. Proc Natl Acad Sci U S A (2004) 2.86

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pH-dependent perforation of macrophage phagosomes by listeriolysin O from Listeria monocytogenes. J Exp Med (1997) 2.26

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Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst. Mol Microbiol (2004) 2.26

The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid. Proc Natl Acad Sci U S A (1994) 2.22

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Mammalian septins are required for phagosome formation. Mol Biol Cell (2008) 1.16

The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia. J Biol Chem (2003) 1.16

Nramp1 modifies the fusion of Salmonella typhimurium-containing vacuoles with cellular endomembranes in macrophages. J Biol Chem (2001) 1.15

Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B. J Gen Physiol (2004) 1.15

Syntaxins 13 and 7 function at distinct steps during phagocytosis. J Immunol (2002) 1.13

Coronin-1 function is required for phagosome formation. Mol Biol Cell (2005) 1.12

Fusion, fission, and secretion during phagocytosis. Physiology (Bethesda) (2007) 1.11

Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosis. J Biol Chem (2003) 1.11

Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants. J Clin Invest (2008) 1.10

Phosphatidylserine dynamics in cellular membranes. Mol Biol Cell (2012) 1.10

Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. J Biol Chem (2003) 1.09

Evidence for a fence that impedes the diffusion of phosphatidylinositol 4,5-bisphosphate out of the forming phagosomes of macrophages. Mol Biol Cell (2011) 1.09

Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4. Infect Immun (2009) 1.08

An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis. J Cell Biol (2009) 1.08

Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase. J Gen Physiol (2007) 1.07

Phagocytosis and the microtubule cytoskeleton. Biochem Cell Biol (2002) 1.07

Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole. Cell Microbiol (2010) 1.07

Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets. J Cell Biol (2010) 1.06

Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. J Biol Chem (2003) 1.06

Expression and subcellular localization of NRAMP1 in human neutrophil granules. Blood (2002) 1.05

CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. J Immunol (2009) 1.05

Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis. J Biol Chem (2009) 1.04

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell (2013) 1.04

Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling. Mol Biol Cell (2011) 1.03

Enteropathogenic Escherichia coli subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection. Mol Biol Cell (2008) 1.03

CD44 is a phagocytic receptor. Blood (2006) 1.03

Carboxyl-terminus determinants of the iron transporter DMT1/SLC11A2 isoform II (-IRE/1B) mediate internalization from the plasma membrane into recycling endosomes. Biochemistry (2005) 1.02

Localized exocytosis of primary (lysosomal) granules during phagocytosis: role of Ca2+-dependent tyrosine phosphorylation and microtubules. J Immunol (2002) 1.02

Cholesterol accumulation by macrophages impairs phagosome maturation. J Biol Chem (2008) 1.02

Subversion of phagocytosis for pathogen survival. Cell Host Microbe (2012) 1.02

Role of ubiquitin and proteasomes in phagosome maturation. Mol Biol Cell (2005) 1.01

Golgi-bound Rab34 is a novel member of the secretory pathway. Mol Biol Cell (2007) 1.01

Phagocytosis: receptors, signal integration, and the cytoskeleton. Immunol Rev (2014) 1.01

Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. J Biol Chem (2005) 1.01

Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes. J Cell Biol (2010) 1.00

Regulation from within: the cytoskeleton in transmembrane signaling. Trends Cell Biol (2012) 0.99

Membrane surface charge dictates the structure and function of the epithelial Na+/H+ exchanger. EMBO J (2011) 0.99