Published in JAMA on February 23, 2016
Value of Urine sTREM-1 on Early Predicting AKI in Sepsis | NCT02920736
Neuromuscular Electrical Stimulation and Septic Shock | NCT03193164
Controlled Fluid Resuscitation in Sepsis | NCT03214913
Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients | NCT03246893
Predict Sepsis; the Predictive Value of Bedside Measures in the Ambulance | NCT03249597
Hemospec Device for the Diagnosis of Sepsis (INTELLIGENCE-1) | NCT03306186
Prognostic Value of Red Cell Distribution Width (RDW) in Neonatal Sepsis | NCT03403062
Esomeprazole to Reduce Organ Failure in Sepsis (PPI-SEPSIS) | NCT03452865
Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock (GOAL) | NCT03461900
Pharmacokinetics of XueBiJing in Patients With Sepsis | NCT03475732
Presepsin in the Diagnosis of Sepsis in Critically Ill Patients | NCT03584594
Vancomycin De-escalation Therapy in Patients With Pneumonia | NCT03586362
Collection of Clinical Specimens From Volunteers for Assay Development | NCT03606382
Treatment of Severe Infection With Antihyperlipidemia Drug | NCT03634293
Ascorbic Acid and Thiamine Effect in Septic Shock (ATESS) | NCT03756220
A Trial of Vitamin B12 in Septic Shock (B12) | NCT03783091
Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock | NCT03828929
Fast Assay for Pathogen Identification and Characterization (FAPIC) | NCT03841162
Infections Following NeuroSurgery (INS) (INS) | NCT03857295
Field Paramedic Application of Sepsis Triage (FAST) | NCT03870789
Therapeutic Plasma Exchange in Adults Patients With Severe Sepsis | NCT04057872
HostDx Sepsis in Patients With Suspected Infections (SEPSIS-SHIELD) | NCT04094818
Rapid Recognition of Corticosteroid Resistant or Sensitive Sepsis (RECORDS) | NCT04280497
Validation of Molecular and Protein Biomarkers in Sepsis (VAMp-sepsis) | NCT04289506
Evaluation of Infection in Obstructing Urolithiasis (eIOU) | NCT04332861
Predicting Death and ICU Admission in COVID-19 Patients in ED | NCT04371562
Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA (SshOCTA) | NCT04593212
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1 | NCT04718623
Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment | NCT04991376
Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock | NCT05192213
ED Tracking Sheet Implementation | NCT05213923
Iron Metabolism Disorders in Patients With Sepsis or Septic Shock. | NCT05217836
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World J Emerg Surg (2016) 1.55
Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood (2017) 1.41
Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial. Ann Intensive Care (2016) 1.39
The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg (2017) 1.38
Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial. JAMA (2017) 1.37
Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial. JAMA (2016) 1.31
qSOFA does not replace SIRS in the definition of sepsis. Crit Care (2016) 1.17
Composition of the Sepsis Definitions Task Force. JAMA (2016) 1.12
Composition of the Sepsis Definitions Task Force. JAMA (2016) 1.12
Composition of the Sepsis Definitions Task Force. JAMA (2016) 1.10
Late mortality after sepsis: propensity matched cohort study. BMJ (2016) 1.09
Estimating Ten-Year Trends in Septic Shock Incidence and Mortality in United States Academic Medical Centers Using Clinical Data. Chest (2016) 1.05
qSOFA, SIRS, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients Outside the ICU. Am J Respir Crit Care Med (2016) 1.03
Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design. Am J Respir Crit Care Med (2016) 1.01
Reducing the global burden of sepsis. CMAJ (2017) 1.00
Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study. Intensive Care Med (2016) 0.99
Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EBioMedicine (2016) 0.97
The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care (2016) 0.95
Prediction of Sepsis in the Intensive Care Unit With Minimal Electronic Health Record Data: A Machine Learning Approach. JMIR Med Inform (2016) 0.95
Opening the Debate on the New Sepsis Definition Change Is Not Necessarily Progress: Revision of the Sepsis Definition Should Be Based on New Scientific Insights. Am J Respir Crit Care Med (2016) 0.94
Increased body mass index and adjusted mortality in ICU patients with sepsis or septic shock: a systematic review and meta-analysis. Crit Care (2016) 0.94
Definitions for Sepsis and Septic Shock. JAMA (2016) 0.93
Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival. Crit Care (2016) 0.93
Definitions for Sepsis and Septic Shock. JAMA (2016) 0.92
Control groups in recent septic shock trials: a systematic review. Intensive Care Med (2016) 0.92
High-performance detection and early prediction of septic shock for alcohol-use disorder patients. Ann Med Surg (Lond) (2016) 0.91
Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality. EBioMedicine (2016) 0.90
Definitions for Sepsis and Septic Shock. JAMA (2016) 0.90
Identifying Patients with Sepsis on the Hospital Wards. Chest (2016) 0.90
Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies. Crit Care (2016) 0.89
AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital. J Thorac Dis (2016) 0.89
Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes. Crit Care (2016) 0.89
Use of CRB-65 and quick Sepsis-related Organ Failure Assessment to predict site of care and mortality in pneumonia patients in the emergency department: a retrospective study. Crit Care (2016) 0.87
Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia. Am J Respir Crit Care Med (2016) 0.87
Definitions for Sepsis and Septic Shock. JAMA (2016) 0.86
Big data to the rescue of systemic inflammatory response syndrome: is electronic data mining the way of the future? Ann Transl Med (2016) 0.86
Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome. Crit Care Med (2016) 0.86
Opening the Debate on the New Sepsis Definition Defining Sepsis: A Case of Bounded Rationality and Fuzzy Thinking? Am J Respir Crit Care Med (2016) 0.85
Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85
The new sepsis consensus definitions (Sepsis-3): the good, the not-so-bad, and the actually-quite-pretty. Intensive Care Med (2016) 0.85
A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood. EBioMedicine (2016) 0.84
Hemoadsorption by CytoSorb in septic patients: a case series. Crit Care (2017) 0.84
Effect of extracorporeal cytokine removal on vascular barrier function in a septic shock patient. J Intensive Care (2017) 0.83
Understanding circulatory failure in sepsis. Intensive Care Med (2016) 0.83
Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates. Crit Care (2016) 0.82
Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy. Intensive Care Med (2016) 0.82
Dopaminergic Regulation of Innate Immunity: a Review. J Neuroimmune Pharmacol (2017) 0.81
The Endothelial Glycocalyx: New Diagnostic and Therapeutic Approaches in Sepsis. Biomed Res Int (2016) 0.81
Application of a simplified definition of diastolic function in severe sepsis and septic shock. Crit Care (2016) 0.81
The new sepsis consensus definitions: the good, the bad and the ugly. Intensive Care Med (2016) 0.81
Diagnosing sepsis - The role of laboratory medicine. Clin Chim Acta (2016) 0.81
The Clinical Challenge of Sepsis Identification and Monitoring. PLoS Med (2016) 0.81
Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study. Lancet Infect Dis (2017) 0.80
Sepsis-3 definitions predict ICU mortality in a low-middle-income country. Ann Intensive Care (2016) 0.80
Sepsis surveillance from administrative data in the absence of a perfect verification. Ann Epidemiol (2016) 0.80
The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Sci Rep (2016) 0.80
Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial. Intensive Care Med (2017) 0.80
Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity. Crit Care (2016) 0.79
Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression. Pharmacol Res (2016) 0.79
Temporal trends of β-haemolytic streptococcal osteoarticular infections in western Norway. BMC Infect Dis (2016) 0.79
Lipid Use and Misuse by the Heart. Circ Res (2016) 0.79
Lymphopenia, Infectious Complications, and Outcome in Spontaneous Intracerebral Hemorrhage. Neurocrit Care (2016) 0.79
A retrospective study of pyogenic liver abscess focusing on Klebsiella pneumoniae as a primary pathogen in China from 1994 to 2015. Sci Rep (2016) 0.79
The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol (2017) 0.79
The Role of ACTH and Corticosteroids for Sepsis and Septic Shock: An Update. Front Endocrinol (Lausanne) (2016) 0.78
Blood Lactate Levels Cutoff and Mortality Prediction in Sepsis-Time for a Reappraisal? a Retrospective Cohort Study. Shock (2016) 0.78
Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci Rep (2016) 0.78
Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity. Ann Intensive Care (2017) 0.78
The immune system's role in sepsis progression, resolution, and long-term outcome. Immunol Rev (2016) 0.78
Data that drive: Closing the loop in the learning hospital system. J Hosp Med (2016) 0.78
Alterations in metabolic patterns in critically ill patients-is there need of action? Eur J Clin Nutr (2017) 0.78
Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis. Crit Care (2017) 0.77
Prognostic impact of restored sinus rhythm in patients with sepsis and new-onset atrial fibrillation. Crit Care (2016) 0.77
Definitions for Sepsis and Septic Shock--Reply. JAMA (2016) 0.77
NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis. Am J Respir Crit Care Med (2017) 0.77
Future of sepsis therapies. Crit Care (2016) 0.77
Utility of the Richmond Agitation-Sedation Scale in evaluation of acute neurologic dysfunction in the intensive care unit. J Thorac Dis (2016) 0.77
[Epistemology in the intensive care unit-what is the purpose of a definition? : Paradigm shift in sepsis research]. Anaesthesist (2017) 0.77
Carbapenemase-producing Klebsiella pneumoniae bloodstream infection in critically ill patients: risk factors and predictors of mortality. Eur J Clin Microbiol Infect Dis (2017) 0.77
Clinical Significance of Commensal Gram-Positive Rods Routinely Isolated from Patient Samples. J Clin Microbiol (2016) 0.77
Pharmacokinetics of Piperacillin in Critically Ill Australian Indigenous Patients with Severe Sepsis. Antimicrob Agents Chemother (2016) 0.76
Importance of whole genome sequencing for the assessment of outbreaks in diagnostic laboratories: analysis of a case series of invasive Streptococcus pyogenes infections. Eur J Clin Microbiol Infect Dis (2017) 0.76
A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study. Ann Intensive Care (2017) 0.76
Role of the IL-33-ST2 axis in sepsis. Mil Med Res (2017) 0.76
Innovation Management? Orienting Sepsis R&D and Technology Transfer Towards Stratified Medicine. EBioMedicine (2016) 0.76
A Dormant Microbial Component in the Development of Preeclampsia. Front Med (Lausanne) (2016) 0.76
Epidermal Growth Factor Improves Intestinal Integrity and Survival in Murine Sepsis Following Chronic Alcohol Ingestion. Shock (2016) 0.76
Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice. Sci Rep (2016) 0.76
Prevalence and risk factors of sepsis-induced cardiomyopathy: A retrospective cohort study. Medicine (Baltimore) (2016) 0.76
Septic shock in the era of precision medicine. J Thorac Dis (2016) 0.76
Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS. Lipids Health Dis (2016) 0.76
Prognostic value of PCT in septic emergency patients. Ann Intensive Care (2016) 0.76
Comparison of Automated Methods Versus the American Burn Association Sepsis Definition to Identify Sepsis and Sepsis With Organ Dysfunction/Septic Shock in Burn-Injured Adults. J Burn Care Res (2017) 0.76
Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection. JCI Insight (2016) 0.76
Understanding Long-Term Outcomes Following Sepsis: Implications and Challenges. Curr Infect Dis Rep (2016) 0.76
Anti-PD-L1 peptide improves survival in sepsis. J Surg Res (2016) 0.76
Towards precision medicine for sepsis patients. Crit Care (2017) 0.76
Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study. Crit Care (2016) 0.76
Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4(+)CD25(+) Regulatory T Cells. Sci Rep (2016) 0.75
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