The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

PubWeight™: 17.49‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMID 26903338)

Published in JAMA on February 23, 2016

Authors

Mervyn Singer1, Clifford S Deutschman2, Christopher Warren Seymour3, Manu Shankar-Hari4, Djillali Annane5, Michael Bauer6, Rinaldo Bellomo7, Gordon R Bernard8, Jean-Daniel Chiche9, Craig M Coopersmith10, Richard S Hotchkiss11, Mitchell M Levy12, John C Marshall13, Greg S Martin14, Steven M Opal12, Gordon D Rubenfeld15, Tom van der Poll16, Jean-Louis Vincent17, Derek C Angus18

Author Affiliations

1: Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom.
2: Hofstra-Northwell School of Medicine, Feinstein Institute for Medical Research, New Hyde Park, New York.
3: Department of Critical Care and Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
4: Department of Critical Care Medicine, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
5: Department of Critical Care Medicine, University of Versailles, France.
6: Center for Sepsis Control and Care, University Hospital, Jena, Germany.
7: Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, and Austin Hospital, Melbourne, Victoria, Australia.
8: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University, Nashville, Tennessee.
9: Réanimation Médicale-Hôpital Cochin, Descartes University, Cochin Institute, Paris, France.
10: Critical Care Center, Emory University School of Medicine, Atlanta, Georgia.
11: Washington University School of Medicine, St Louis, Missouri.
12: Infectious Disease Section, Division of Pulmonary and Critical Care Medicine, Brown University School of Medicine, Providence, Rhode Island.
13: Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
14: Emory University School of Medicine and Grady Memorial Hospital, Atlanta, Georgia.
15: Trauma, Emergency & Critical Care Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada16Interdepartmental Division of Critical Care, University of Toronto.
16: Department of Infectious Diseases, Academisch Medisch Centrum, Amsterdam, the Netherlands.
17: Department of Intensive Care, Erasme University Hospital, Brussels, Belgium.
18: Department of Critical Care Medicine, University of Pittsburgh and UPMC Health System, Pittsburgh, Pennsylvania20Associate Editor, JAMA.

Associated clinical trials:

Investigation of Inflammatory Parameters in a Perioperative Closed-meshed Standard Progress in CPB Patients | NCT02963480

Value of Urine sTREM-1 on Early Predicting AKI in Sepsis | NCT02920736

Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis | NCT02805049

Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock | NCT03014063

Fast Assay for Pathogen Identification and Characterization - Prospective Study (FAPIC) | NCT03025802

Probiotic Prophylaxis for Microbiome Modulation and VAP or Infections Prevention in Multitrauma Patients | NCT03074552

Neuromuscular Electrical Stimulation and Septic Shock | NCT03193164

Controlled Fluid Resuscitation in Sepsis | NCT03214913

Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients | NCT03246893

Predict Sepsis; the Predictive Value of Bedside Measures in the Ambulance | NCT03249597

Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis | NCT03278730

Impact of qSOFA Calculation on the Timing of Antimicrobial Therapy in the Emergency Department (qSOFAST) | NCT03299894

Hemospec Device for the Diagnosis of Sepsis (INTELLIGENCE-1) | NCT03306186

Prognostic Value of Red Cell Distribution Width (RDW) in Neonatal Sepsis | NCT03403062

Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis (PTMVP) | NCT03406494

Esomeprazole to Reduce Organ Failure in Sepsis (PPI-SEPSIS) | NCT03452865

Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock (GOAL) | NCT03461900

Pharmacokinetics of XueBiJing in Patients With Sepsis | NCT03475732

Presepsin in the Diagnosis of Sepsis in Critically Ill Patients | NCT03584594

Vancomycin De-escalation Therapy in Patients With Pneumonia | NCT03586362

Turkish Prospective Cohort Study on Carbapenem Resistant Klebsiella Pneumonia Bacteremia (THREAT) | NCT03597841

Collection of Clinical Specimens From Volunteers for Assay Development | NCT03606382

Treatment of Severe Infection With Antihyperlipidemia Drug | NCT03634293

Ascorbic Acid and Thiamine Effect in Septic Shock (ATESS) | NCT03756220

A Trial of Vitamin B12 in Septic Shock (B12) | NCT03783091

Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock | NCT03828929

Fast Assay for Pathogen Identification and Characterization (FAPIC) | NCT03841162

Infections Following NeuroSurgery (INS) (INS) | NCT03857295

Field Paramedic Application of Sepsis Triage (FAST) | NCT03870789

Therapeutic Plasma Exchange in Adults Patients With Severe Sepsis | NCT04057872

Combination Treatment for Enterococcus Faecalis Bacteriemia Multicenter, Observational Study" | NCT04070820

HostDx Sepsis in Patients With Suspected Infections (SEPSIS-SHIELD) | NCT04094818

Fast Assay for Pathogen Identification - Quasi-Experimental Intervention Study (FAPIC-QE) | NCT04103203

Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient | NCT04169412

Rapid Recognition of Corticosteroid Resistant or Sensitive Sepsis (RECORDS) | NCT04280497

Validation of Molecular and Protein Biomarkers in Sepsis (VAMp-sepsis) | NCT04289506

Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care in Turkey | NCT04304456

Evaluation of Infection in Obstructing Urolithiasis (eIOU) | NCT04332861

Predicting Death and ICU Admission in COVID-19 Patients in ED | NCT04371562

Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia | NCT04396522

Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA (SshOCTA) | NCT04593212

Validation of the Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) in Obstetric Patients (COLOSSAL) | NCT04621539

Effects of Hydrocortison Treatment on Angiotensin II and Angiotensin II Receptors in Patients With Septic Shock | NCT04647552

Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients (AUSTRALIS) | NCT04693923

Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1 | NCT04718623

Extracorporal Cytokin Removal in Septic Shock: a Prospective, Randomized, Multicenter Clinical Trial (DECRISS) | NCT04742764

Early Recognition and Dynamic Risk Warning System of Multiple Organ Dysfunction Syndrome Caused by Sepsis | NCT04904289

Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment | NCT04991376

CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock (CLEANSE) | NCT05136183

Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock | NCT05192213

Prognosis of Klebsiella ESBL Sepsis: Role of 2-HYDRoxy-myristate in Endotoxin Structure (PoKES2_HYDRES) | NCT05193045

ED Tracking Sheet Implementation | NCT05213923

Iron Metabolism Disorders in Patients With Sepsis or Septic Shock. | NCT05217836

Articles citing this

(truncated to the top 100)

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA (2016) 4.87

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World J Emerg Surg (2016) 1.55

Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood (2017) 1.41

Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial. Ann Intensive Care (2016) 1.39

The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg (2017) 1.38

Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial. JAMA (2017) 1.37

Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial. JAMA (2016) 1.31

qSOFA does not replace SIRS in the definition of sepsis. Crit Care (2016) 1.17

Composition of the Sepsis Definitions Task Force. JAMA (2016) 1.12

Composition of the Sepsis Definitions Task Force. JAMA (2016) 1.12

Composition of the Sepsis Definitions Task Force. JAMA (2016) 1.10

Late mortality after sepsis: propensity matched cohort study. BMJ (2016) 1.09

Estimating Ten-Year Trends in Septic Shock Incidence and Mortality in United States Academic Medical Centers Using Clinical Data. Chest (2016) 1.05

qSOFA, SIRS, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients Outside the ICU. Am J Respir Crit Care Med (2016) 1.03

Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design. Am J Respir Crit Care Med (2016) 1.01

Reducing the global burden of sepsis. CMAJ (2017) 1.00

Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study. Intensive Care Med (2016) 0.99

Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EBioMedicine (2016) 0.97

The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care (2016) 0.95

Prediction of Sepsis in the Intensive Care Unit With Minimal Electronic Health Record Data: A Machine Learning Approach. JMIR Med Inform (2016) 0.95

Opening the Debate on the New Sepsis Definition Change Is Not Necessarily Progress: Revision of the Sepsis Definition Should Be Based on New Scientific Insights. Am J Respir Crit Care Med (2016) 0.94

Increased body mass index and adjusted mortality in ICU patients with sepsis or septic shock: a systematic review and meta-analysis. Crit Care (2016) 0.94

Definitions for Sepsis and Septic Shock. JAMA (2016) 0.93

Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival. Crit Care (2016) 0.93

Definitions for Sepsis and Septic Shock. JAMA (2016) 0.92

Control groups in recent septic shock trials: a systematic review. Intensive Care Med (2016) 0.92

High-performance detection and early prediction of septic shock for alcohol-use disorder patients. Ann Med Surg (Lond) (2016) 0.91

Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality. EBioMedicine (2016) 0.90

Definitions for Sepsis and Septic Shock. JAMA (2016) 0.90

Identifying Patients with Sepsis on the Hospital Wards. Chest (2016) 0.90

Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies. Crit Care (2016) 0.89

AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital. J Thorac Dis (2016) 0.89

Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes. Crit Care (2016) 0.89

Use of CRB-65 and quick Sepsis-related Organ Failure Assessment to predict site of care and mortality in pneumonia patients in the emergency department: a retrospective study. Crit Care (2016) 0.87

Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia. Am J Respir Crit Care Med (2016) 0.87

Definitions for Sepsis and Septic Shock. JAMA (2016) 0.86

Big data to the rescue of systemic inflammatory response syndrome: is electronic data mining the way of the future? Ann Transl Med (2016) 0.86

Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome. Crit Care Med (2016) 0.86

Opening the Debate on the New Sepsis Definition Defining Sepsis: A Case of Bounded Rationality and Fuzzy Thinking? Am J Respir Crit Care Med (2016) 0.85

Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85

The new sepsis consensus definitions (Sepsis-3): the good, the not-so-bad, and the actually-quite-pretty. Intensive Care Med (2016) 0.85

A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood. EBioMedicine (2016) 0.84

Hemoadsorption by CytoSorb in septic patients: a case series. Crit Care (2017) 0.84

Effect of extracorporeal cytokine removal on vascular barrier function in a septic shock patient. J Intensive Care (2017) 0.83

Understanding circulatory failure in sepsis. Intensive Care Med (2016) 0.83

Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates. Crit Care (2016) 0.82

Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy. Intensive Care Med (2016) 0.82

Dopaminergic Regulation of Innate Immunity: a Review. J Neuroimmune Pharmacol (2017) 0.81

The Endothelial Glycocalyx: New Diagnostic and Therapeutic Approaches in Sepsis. Biomed Res Int (2016) 0.81

Application of a simplified definition of diastolic function in severe sepsis and septic shock. Crit Care (2016) 0.81

The new sepsis consensus definitions: the good, the bad and the ugly. Intensive Care Med (2016) 0.81

Diagnosing sepsis - The role of laboratory medicine. Clin Chim Acta (2016) 0.81

The Clinical Challenge of Sepsis Identification and Monitoring. PLoS Med (2016) 0.81

Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study. Lancet Infect Dis (2017) 0.80

Sepsis-3 definitions predict ICU mortality in a low-middle-income country. Ann Intensive Care (2016) 0.80

Sepsis surveillance from administrative data in the absence of a perfect verification. Ann Epidemiol (2016) 0.80

The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Sci Rep (2016) 0.80

Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial. Intensive Care Med (2017) 0.80

Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity. Crit Care (2016) 0.79

Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression. Pharmacol Res (2016) 0.79

Temporal trends of β-haemolytic streptococcal osteoarticular infections in western Norway. BMC Infect Dis (2016) 0.79

Lipid Use and Misuse by the Heart. Circ Res (2016) 0.79

Lymphopenia, Infectious Complications, and Outcome in Spontaneous Intracerebral Hemorrhage. Neurocrit Care (2016) 0.79

A retrospective study of pyogenic liver abscess focusing on Klebsiella pneumoniae as a primary pathogen in China from 1994 to 2015. Sci Rep (2016) 0.79

The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol (2017) 0.79

The Role of ACTH and Corticosteroids for Sepsis and Septic Shock: An Update. Front Endocrinol (Lausanne) (2016) 0.78

Blood Lactate Levels Cutoff and Mortality Prediction in Sepsis-Time for a Reappraisal? a Retrospective Cohort Study. Shock (2016) 0.78

Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci Rep (2016) 0.78

Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity. Ann Intensive Care (2017) 0.78

The immune system's role in sepsis progression, resolution, and long-term outcome. Immunol Rev (2016) 0.78

Data that drive: Closing the loop in the learning hospital system. J Hosp Med (2016) 0.78

Alterations in metabolic patterns in critically ill patients-is there need of action? Eur J Clin Nutr (2017) 0.78

Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis. Crit Care (2017) 0.77

Prognostic impact of restored sinus rhythm in patients with sepsis and new-onset atrial fibrillation. Crit Care (2016) 0.77

Definitions for Sepsis and Septic Shock--Reply. JAMA (2016) 0.77

NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis. Am J Respir Crit Care Med (2017) 0.77

Future of sepsis therapies. Crit Care (2016) 0.77

Utility of the Richmond Agitation-Sedation Scale in evaluation of acute neurologic dysfunction in the intensive care unit. J Thorac Dis (2016) 0.77

[Epistemology in the intensive care unit-what is the purpose of a definition? : Paradigm shift in sepsis research]. Anaesthesist (2017) 0.77

Carbapenemase-producing Klebsiella pneumoniae bloodstream infection in critically ill patients: risk factors and predictors of mortality. Eur J Clin Microbiol Infect Dis (2017) 0.77

Clinical Significance of Commensal Gram-Positive Rods Routinely Isolated from Patient Samples. J Clin Microbiol (2016) 0.77

Pharmacokinetics of Piperacillin in Critically Ill Australian Indigenous Patients with Severe Sepsis. Antimicrob Agents Chemother (2016) 0.76

Importance of whole genome sequencing for the assessment of outbreaks in diagnostic laboratories: analysis of a case series of invasive Streptococcus pyogenes infections. Eur J Clin Microbiol Infect Dis (2017) 0.76

A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study. Ann Intensive Care (2017) 0.76

Role of the IL-33-ST2 axis in sepsis. Mil Med Res (2017) 0.76

Innovation Management? Orienting Sepsis R&D and Technology Transfer Towards Stratified Medicine. EBioMedicine (2016) 0.76

A Dormant Microbial Component in the Development of Preeclampsia. Front Med (Lausanne) (2016) 0.76

Epidermal Growth Factor Improves Intestinal Integrity and Survival in Murine Sepsis Following Chronic Alcohol Ingestion. Shock (2016) 0.76

Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice. Sci Rep (2016) 0.76

Prevalence and risk factors of sepsis-induced cardiomyopathy: A retrospective cohort study. Medicine (Baltimore) (2016) 0.76

Septic shock in the era of precision medicine. J Thorac Dis (2016) 0.76

Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS. Lipids Health Dis (2016) 0.76

Prognostic value of PCT in septic emergency patients. Ann Intensive Care (2016) 0.76

Comparison of Automated Methods Versus the American Burn Association Sepsis Definition to Identify Sepsis and Sepsis With Organ Dysfunction/Septic Shock in Burn-Injured Adults. J Burn Care Res (2017) 0.76

Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection. JCI Insight (2016) 0.76

Understanding Long-Term Outcomes Following Sepsis: Implications and Challenges. Curr Infect Dis Rep (2016) 0.76

Anti-PD-L1 peptide improves survival in sepsis. J Surg Res (2016) 0.76

Towards precision medicine for sepsis patients. Crit Care (2017) 0.76

Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study. Crit Care (2016) 0.76

Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4(+)CD25(+) Regulatory T Cells. Sci Rep (2016) 0.75

Articles cited by this

Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med (1996) 35.00

American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med (1992) 20.79

Severe sepsis and septic shock. N Engl J Med (2013) 14.31

Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med (1998) 13.94

Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA (2010) 10.82

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39

Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med (2015) 7.73

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med (1999) 7.24

Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med (2013) 6.04

Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA (2016) 5.79

Lactic acidosis. N Engl J Med (2014) 5.78

Sepsis definitions: time for change. Lancet (2013) 5.63

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA (2016) 4.87

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol (2013) 4.38

The Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group. JAMA (1996) 4.30

Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med (2015) 3.55

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. Am J Respir Crit Care Med (2016) 3.38

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med (2014) 3.37

Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc (2012) 2.78

Incidence and Prognostic Value of the Systemic Inflammatory Response Syndrome and Organ Dysfunctions in Ward Patients. Am J Respir Crit Care Med (2015) 2.53

Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet (2004) 2.52

An international survey: Public awareness and perception of sepsis. Crit Care Med (2009) 2.40

An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23

Sepsis: current dogma and new perspectives. Immunity (2014) 2.22

Alarmins: awaiting a clinical response. J Clin Invest (2012) 2.19

Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet Respir Med (2014) 2.13

Regulatory mandates for sepsis care--reasons for caution. N Engl J Med (2014) 2.11

Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med (2015) 2.09

Capillary refill time exploration during septic shock. Intensive Care Med (2014) 1.99

"Merinoff symposium 2010: sepsis"-speaking with one voice. Mol Med (2011) 1.81

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev (2013) 1.72

Host innate immune responses to sepsis. Virulence (2013) 1.66

Transcriptional instability during evolving sepsis may limit biomarker based risk stratification. PLoS One (2013) 1.41

Increasing percutaneous coronary interventions for ST-segment elevation myocardial infarction in the United States: progress and opportunity. JACC Cardiovasc Interv (2014) 1.27