Published in EBioMedicine on June 13, 2016
The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med (2003) 32.30
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med (2006) 23.62
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA (2016) 17.49
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Severe sepsis and septic shock. N Engl J Med (2013) 14.31
Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med (2015) 7.73
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med (2014) 5.70
Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial. Crit Care Med (2011) 5.28
Sepsis biomarkers: a review. Crit Care (2010) 4.76
Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med (2006) 4.46
Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet (1989) 3.12
Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome) JAMA (1993) 2.88
Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia. Crit Care Med (2008) 2.39
T2 magnetic resonance assay for the rapid diagnosis of candidemia in whole blood: a clinical trial. Clin Infect Dis (2015) 2.28
Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA (2014) 2.23
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17
Polymyxin B-immobilized fiber column hemoperfusion therapy for septic shock. Shock (2011) 2.11
Procalcitonin in the burn unit and the diagnosis of infection. Burns (2014) 2.04
Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis. BMC Infect Dis (2009) 1.83
Antibiotic-induced release of endotoxin: a reappraisal. Clin Infect Dis (1992) 1.82
Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens (2006) 1.66
Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. J Clin Microbiol (2009) 1.63
Utility of a commercially available multiplex real-time PCR assay to detect bacterial and fungal pathogens in febrile neutropenia. J Clin Microbiol (2009) 1.59
Improved detection of blood stream pathogens by real-time PCR in severe sepsis. Intensive Care Med (2009) 1.51
An extracorporeal blood-cleansing device for sepsis therapy. Nat Med (2014) 1.29
Potential clinical utility of polymerase chain reaction in microbiological testing for sepsis. Crit Care Med (2009) 1.29
Discriminative value of inflammatory biomarkers for suspected sepsis. J Emerg Med (2011) 1.26
Improved sensitivity for molecular detection of bacterial and Candida infections in blood. J Clin Microbiol (2014) 1.25
Use of a novel hemoadsorption device for cytokine removal as adjuvant therapy in a patient with septic shock with multi-organ dysfunction: A case study. Indian J Crit Care Med (2014) 1.18
Biomarkers and molecular analysis to improve bloodstream infection diagnostics in an emergency care unit. PLoS One (2014) 1.17
Anti-microbial activities of mannose-binding lectin. Biochem Soc Trans (2003) 1.16
Activation of complement by mannose-binding lectin on isogenic mutants of Neisseria meningitidis serogroup B. J Immunol (1998) 1.13
Sepsis biomarkers. Clin Chim Acta (2014) 1.10
Early diagnosis of sepsis using serum biomarkers. Expert Rev Mol Diagn (2011) 1.08
Evaluation of the Broad-Range PCR/ESI-MS Technology in Blood Specimens for the Molecular Diagnosis of Bloodstream Infections. PLoS One (2015) 1.05
Rapid identification of microorganisms from positive blood cultures by MALDI-TOF mass spectrometry subsequent to very short-term incubation on solid medium. Clin Microbiol Infect (2014) 1.04
Effect of empiric antibiotic treatment on plasma endotoxin activity in septic patients. Infection (2014) 0.98
Bench-to-bedside review: Clinical experience with the endotoxin activity assay. Crit Care (2012) 0.95
Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting. Intensive Care Med (2015) 0.93
Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications. Crit Care Med (2016) 0.92
A novel role for the bactericidal/permeability increasing protein in interactions of gram-negative bacterial outer membrane blebs with dendritic cells. J Immunol (2007) 0.90
Severe sepsis and systemic inflammatory response syndrome in emergency department patients with suspected severe infection. Scand J Infect Dis (2012) 0.88
Limulus amebocyte lysate assay for detection of endotoxin in patients with sepsis syndrome. AMCC Sepsis Project Working Group. Clin Infect Dis (1998) 0.84
Using procalcitonin-guided algorithms to improve antimicrobial therapy in ICU patients with respiratory infections and sepsis. Curr Opin Crit Care (2013) 0.83
Removal of Carbapenem-Resistant Enterobacteriaceae (CRE) from blood by heparin-functional hemoperfusion media. PLoS One (2014) 0.83
Host response biomarkers in the diagnosis of sepsis: a general overview. Methods Mol Biol (2015) 0.82
Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption. Biomaterials (2015) 0.81
Serum C-reactive protein and procalcitonin kinetics in patients undergoing elective total hip arthroplasty. Biomed Res Int (2014) 0.80
Serum levels of procalcitonin and high sensitivity C-reactive protein are associated with long-term mortality in acute ischemic stroke. J Neurol Sci (2015) 0.79
Identification of Predictive Early Biomarkers for Sterile-SIRS after Cardiovascular Surgery. PLoS One (2015) 0.79
Endotoxemia as a diagnostic tool for patients with suspected bacteremia caused by gram-negative organisms: a meta-analysis of 4 decades of studies. J Clin Microbiol (2015) 0.77
Modeling hepatitis C virus therapies combining drugs and lectin affinity plasmapheresis. Blood Purif (2010) 0.76
Procalcitonin-guided antibiotic therapy for septic patients in the surgical intensive care unit. J Intensive Care (2015) 0.76
Evaluation of a multiplex OnSpot Primer-Extension PCR assay in the diagnosis of sepsis. J Microbiol Methods (2015) 0.76
Changes of procalcitonin level in multiple trauma patients. Anaesthesiol Intensive Ther (2014) 0.76