Published in Oncotarget on March 29, 2016
Empirical verification of evolutionary theories of aging. Aging (Albany NY) (2016) 0.84
Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms. Front Genet (2016) 0.84
Six plant extracts delay yeast chronological aging through different signaling pathways. Oncotarget (2016) 0.76
Hallmarks of cancer: the next generation. Cell (2011) 140.01
The hallmarks of aging. Cell (2013) 14.29
Extending healthy life span--from yeast to humans. Science (2010) 12.12
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol (2007) 8.10
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science (2006) 7.35
Four faces of cellular senescence. J Cell Biol (2011) 6.86
Understanding the odd science of aging. Cell (2005) 6.50
Mitochondria: in sickness and in health. Cell (2012) 6.05
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal (2012) 5.65
Aging, cellular senescence, and cancer. Annu Rev Physiol (2012) 5.08
Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab (2007) 4.59
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab (2010) 4.11
Lipid droplets and cellular lipid metabolism. Annu Rev Biochem (2012) 4.02
Fat metabolism links germline stem cells and longevity in C. elegans. Science (2008) 3.95
Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab (2005) 3.93
Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol (2007) 3.62
ROS function in redox signaling and oxidative stress. Curr Biol (2014) 3.35
Endocrine regulation of ageing. Nat Rev Mol Cell Biol (2007) 3.28
Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab (2011) 3.13
The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest (2011) 3.12
Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet (2007) 3.07
FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling. Cell Metab (2012) 2.96
Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics. Dev Cell (2015) 2.84
Lessons on longevity from budding yeast. Nature (2010) 2.81
Stress-response hormesis and aging: "that which does not kill us makes us stronger". Cell Metab (2008) 2.71
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci (2014) 2.37
Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature (2008) 2.37
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle (2006) 2.23
Growth and aging: a common molecular mechanism. Aging (Albany NY) (2009) 2.13
Answering the ultimate question "what is the proximal cause of aging?". Aging (Albany NY) (2012) 2.04
Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab (2013) 2.03
Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct (2011) 1.94
Yeast: an experimental organism for 21st Century biology. Genetics (2011) 1.88
Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging (Albany NY) (2009) 1.82
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. Aging (Albany NY) (2010) 1.76
The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics (2004) 1.72
Ageing as a risk factor for disease. Curr Biol (2012) 1.71
The search for antiaging interventions: from elixirs to fasting regimens. Cell (2014) 1.63
Why is aging conserved and what can we do about it? PLoS Biol (2015) 1.50
Compression of morbidity 1980-2011: a focused review of paradigms and progress. J Aging Res (2011) 1.46
Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites. J Cell Biol (2014) 1.45
Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction. Cell Metab (2012) 1.41
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta (2011) 1.40
Balancing the fat: lipid droplets and human disease. EMBO Mol Med (2013) 1.40
Polyamines in aging and disease. Aging (Albany NY) (2011) 1.36
Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol (2013) 1.31
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Mol Aspects Med (2011) 1.27
Effect of calorie restriction on the metabolic history of chronologically aging yeast. Exp Gerontol (2009) 1.27
Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. Genes Dev (2004) 1.26
Mitochondrial ROS Signaling in Organismal Homeostasis. Cell (2015) 1.23
The retrograde response: when mitochondrial quality control is not enough. Biochim Biophys Acta (2012) 1.18
Longevity and aging. F1000Prime Rep (2013) 1.18
Mitochondrial dysfunction and longevity in animals: Untangling the knot. Science (2015) 1.17
Hallmarks of a new era in mitochondrial biochemistry. Genes Dev (2013) 1.15
Mitochondrial membrane lipidome defines yeast longevity. Aging (Albany NY) (2013) 1.14
Hydrogen peroxide as a signaling molecule. Antioxid Redox Signal (2011) 1.14
Peroxisome metabolism and cellular aging. Traffic (2010) 1.13
Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat--store 'em up or burn 'em down. Genetics (2013) 1.13
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome. Cell Cycle (2015) 1.10
TOR signaling never gets old: aging, longevity and TORC1 activity. Ageing Res Rev (2010) 1.07
The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends Genet (2013) 1.07
Expanding roles for lipid droplets. Curr Biol (2015) 1.06
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab (2015) 1.05
Budding yeast as a model organism to study the effects of age. FEMS Microbiol Rev (2014) 1.04
Hormesis provides a generalized quantitative estimate of biological plasticity. J Cell Commun Signal (2011) 1.02
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00
Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents. Cell Cycle (2013) 1.00
Chronological aging in Saccharomyces cerevisiae. Subcell Biochem (2012) 0.98
Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration. Front Physiol (2012) 0.98
Peroxisome biogenesis occurs in an unsynchronized manner in close association with the endoplasmic reticulum in temperature-sensitive Yarrowia lipolytica Pex3p mutants. Mol Biol Cell (2003) 0.96
Open questions in lipid droplet biology. Chem Biol (2013) 0.96
Integration of peroxisomes into an endomembrane system that governs cellular aging. Front Physiol (2012) 0.93
A novel function of lipid droplets in regulating longevity. Biochem Soc Trans (2009) 0.92
Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells. PeerJ (2013) 0.92
Natural compounds with anti-ageing activity. Nat Prod Rep (2013) 0.91
The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects. Vet Pathol (2015) 0.91
Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. Cell Cycle (2012) 0.91
Yeast colonies: a model for studies of aging, environmental adaptation, and longevity. Oxid Med Cell Longev (2012) 0.90
Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis. Aging (Albany NY) (2013) 0.90
Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from "liponecrosis", a previously unknown form of programmed cell death. Cell Cycle (2013) 0.89
Yeast lipid metabolism at a glance. FEMS Yeast Res (2014) 0.89
The retrograde response retrograde response and other pathways of interorganelle communication interorganelle communication in yeast replicative aging. Subcell Biochem (2012) 0.89
The free radical theory of aging is dead. Long live the damage theory! Antioxid Redox Signal (2013) 0.89
Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget (2011) 0.88
Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level. Aging (Albany NY) (2010) 0.88
Mechanisms by which different functional states of mitochondria define yeast longevity. Int J Mol Sci (2015) 0.87
Genome-wide analysis of yeast aging. Subcell Biochem (2012) 0.85
A network of interorganellar communications underlies cellular aging. IUBMB Life (2013) 0.85
Storage lipids of yeasts: a survey of nonpolar lipid metabolism in Saccharomyces cerevisiae, Pichia pastoris, and Yarrowia lipolytica. FEMS Microbiol Rev (2014) 0.85
Essential roles of peroxisomally produced and metabolized biomolecules in regulating yeast longevity. Subcell Biochem (2013) 0.84
In search of housekeeping pathways that regulate longevity. Cell Cycle (2011) 0.84
Protein quality control in time and space - links to cellular aging. FEMS Yeast Res (2013) 0.84
Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan. Cell Cycle (2014) 0.83
Dietary restriction, mitochondrial function and aging: from yeast to humans. Biochim Biophys Acta (2015) 0.83
A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology. Redox Biol (2014) 0.82
Cells with impaired mitochondrial H2O2 sensing generate less •OH radicals and live longer. Antioxid Redox Signal (2014) 0.82
Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER. J Cell Biol (2006) 1.14
Empirical verification of evolutionary theories of aging. Aging (Albany NY) (2016) 0.84
Mitochondria operate as signaling platforms in yeast aging. Aging (Albany NY) (2016) 0.78
Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae. Microb Cell (2014) 0.75
A laboratory test of evolutionary aging theories. Aging (Albany NY) (2017) 0.75
Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae. Front Biosci (Landmark Ed) (2018) 0.75