Published in Biochim Biophys Acta on February 21, 2012
CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. PLoS Genet (2015) 1.49
Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming. Cancer Cell (2016) 1.41
The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction. Front Physiol (2012) 1.14
Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health. Biochim Biophys Acta (2013) 1.10
Mitonuclear communication in homeostasis and stress. Nat Rev Mol Cell Biol (2016) 1.01
Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. PLoS One (2013) 0.96
Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cells. PLoS One (2014) 0.92
Mechanisms by which different functional states of mitochondria define yeast longevity. Int J Mol Sci (2015) 0.87
Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? Int J Mol Sci (2015) 0.87
Adenine nucleotide translocase, mitochondrial stress, and degenerative cell death. Oxid Med Cell Longev (2013) 0.87
Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity. Immun Ageing (2012) 0.87
Divergent branches of mitochondrial signaling regulate specific genes and the viability of specialized cell types of differentiated yeast colonies. Oncotarget (2016) 0.87
Mitochondrial signaling: forwards, backwards, and in between. Oxid Med Cell Longev (2013) 0.86
Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan. Cell Cycle (2014) 0.83
Interplay among Gcn5, Sch9 and mitochondria during chronological aging of wine yeast is dependent on growth conditions. PLoS One (2015) 0.83
Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging. Ageing Res Rev (2014) 0.80
The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response. G3 (Bethesda) (2014) 0.80
Plant mitochondrial retrograde signaling: post-translational modifications enter the stage. Front Plant Sci (2012) 0.80
Mechanism of regulation of 'chromosome kissing' induced by Fob1 and its physiological significance. Genes Dev (2015) 0.80
Sphingolipids and mitochondrial function in budding yeast. Biochim Biophys Acta (2014) 0.79
System-level impact of mitochondria on fungal virulence: to metabolism and beyond. FEMS Yeast Res (2015) 0.78
Programmed Cell Death Initiation and Execution in Budding Yeast. Genetics (2015) 0.78
Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan. Sci Rep (2016) 0.78
Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans. PLoS One (2014) 0.77
Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes. Oncotarget (2016) 0.77
Six plant extracts delay yeast chronological aging through different signaling pathways. Oncotarget (2016) 0.76
Reduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration. Mol Cell Biol (2016) 0.76
Coordinating metabolite changes with our perception of plant abiotic stress responses: emerging views revealed by integrative-omic analyses. Metabolites (2013) 0.76
Role of Mitochondrial Retrograde Pathway in Regulating Ethanol-Inducible Filamentous Growth in Yeast. Front Physiol (2017) 0.75
Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging. Front Genet (2016) 0.75
Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae. Microb Cell (2014) 0.75
Mitochondrial retrograde signaling in the Drosophila nervous system and beyond. Fly (Austin) (2016) 0.75
Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging (Albany NY) (2017) 0.75
Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae. G3 (Bethesda) (2015) 0.75
Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing. Microb Cell (2014) 0.75
Alternative Oxidase Transcription Factors AOD2 and AOD5 of Neurospora crassa Control the Expression of Genes Involved in Energy Production and Metabolism. G3 (Bethesda) (2016) 0.75
Monitoring yeast mitochondria with peroxiredoxin-based redox probes: the influence of oxygen and glucose availability. Interface Focus (2017) 0.75
Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome. Semin Cancer Biol (2017) 0.75
Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans. Aging Cell (2017) 0.75
Sphingolipid accumulation causes mitochondrial dysregulation and cell death. Cell Death Differ (2017) 0.75
TOR signaling in growth and metabolism. Cell (2006) 35.29
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell (2002) 11.59
Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32
Extrachromosomal rDNA circles--a cause of aging in yeast. Cell (1997) 8.68
Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24
Rates of behavior and aging specified by mitochondrial function during development. Science (2002) 6.28
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet (2002) 6.26
The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell (2011) 6.05
Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu Rev Genet (2005) 6.03
A global protein kinase and phosphatase interaction network in yeast. Science (2010) 5.95
Evolution of senescence: late survival sacrificed for reproduction. Philos Trans R Soc Lond B Biol Sci (1991) 5.93
Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell (2009) 5.85
Life span of individual yeast cells. Nature (1959) 5.81
Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell (2007) 5.67
Mitochondrial signaling: the retrograde response. Mol Cell (2004) 4.21
A mitochondrial specific stress response in mammalian cells. EMBO J (2002) 3.95
Mitochondrial retrograde signaling. Annu Rev Genet (2006) 3.75
A mechanism for asymmetric segregation of age during yeast budding. Nature (2008) 3.14
RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell (1993) 3.13
Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell (2009) 3.00
Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol (2009) 2.86
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol (2007) 2.78
Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol (1994) 2.71
Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol Microbiol (2001) 2.68
The mitochondrial genotype can influence nuclear gene expression in yeast. Science (1987) 2.62
Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab (2008) 2.57
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol (2010) 2.55
Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell (2001) 2.55
Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics (1999) 2.50
Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell (2003) 2.48
Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev (2005) 2.39
Crosstalk between nuclear and mitochondrial genomes. Annu Rev Biochem (1996) 2.32
TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem (2004) 2.25
A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol (1997) 2.19
Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Curr Biol (2009) 2.19
Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice. Hum Mol Genet (2007) 2.18
Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae. J Bacteriol (1989) 2.18
Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J Cell Biol (2000) 2.13
Sensors of extracellular nutrients in Saccharomyces cerevisiae. Curr Genet (2001) 2.09
Selective and non-selective autophagic degradation of mitochondria in yeast. Autophagy (2007) 2.07
Mitochondrial inheritance: cell cycle and actin cable dependence of polarized mitochondrial movements in Saccharomyces cerevisiae. Cell Motil Cytoskeleton (1997) 2.06
A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell (2009) 2.04
LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J Cell Biol (2003) 2.01
Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science (2005) 2.01
Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol Biol Cell (2000) 1.98
The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway. Mol Cell Biol (2002) 1.98
Longevity, genes, and aging. Science (1996) 1.97
Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis. Biochim Biophys Acta (2008) 1.96
Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell (2001) 1.96
Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. J Biol Chem (2004) 1.95
Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat Cell Biol (2006) 1.92
Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae. Mol Cell Biol (1991) 1.91
C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO J (2001) 1.89
A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev (1996) 1.83
Early mitochondrial dysfunction in long-lived Mclk1+/- mice. J Biol Chem (2008) 1.81
A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol (2004) 1.81
Interorganellar communication. Altered nuclear gene expression profiles in a yeast mitochondrial dna mutant. J Biol Chem (2000) 1.80
A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae. Genetics (2002) 1.75
Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics (1997) 1.74
Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J Biol Chem (1994) 1.67
Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing. Mol Cell (2011) 1.59
A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Mol Cell (1999) 1.55
Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast. Aging Cell (2011) 1.54
Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J Biol Chem (2000) 1.54
Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae. Curr Biol (2002) 1.54
A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet (2009) 1.52
ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology. J Cell Sci (2010) 1.43
Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res (1998) 1.42
Mitochondrial respiratory electron carriers are involved in oxidative stress during heat stress in Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.39
Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem (1994) 1.38
Mks1p is required for negative regulation of retrograde gene expression in Saccharomyces cerevisiae but does not affect nitrogen catabolite repression-sensitive gene expression. J Biol Chem (2002) 1.37
The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. FASEB J (1995) 1.37
Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics (2008) 1.32
A polymerase switch in the synthesis of rRNA in Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.32
Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem (2003) 1.29
RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J (2001) 1.27
Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains. J Biol Chem (1997) 1.25
Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Mol Cell (2003) 1.24
Rtg2 protein links metabolism and genome stability in yeast longevity. Genetics (2004) 1.22
The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging (Albany NY) (2009) 1.21
Transactivation by Rtg1p, a basic helix-loop-helix protein that functions in communication between mitochondria and the nucleus in yeast. J Biol Chem (1995) 1.21
Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. J Biol Chem (2003) 1.19
Interaction between the yeast mitochondrial and nuclear genomes influences the abundance of novel transcripts derived from the spacer region of the nuclear ribosomal DNA repeat. Mol Cell Biol (1989) 1.19
RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]. Mol Biol Cell (2002) 1.18
Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes. J Biol Chem (2004) 1.18
The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans. PLoS Biol (2011) 1.18
Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression. J Biol Chem (2005) 1.16
Nuclear geometry and rapid mitosis ensure asymmetric episome segregation in yeast. Curr Biol (2010) 1.13
Enzymatic and metabolic studies on retrograde regulation mutants of yeast. Biochemistry (1995) 1.13
Quantitation of (a)symmetric inheritance of functional and of oxidatively damaged mitochondrial aconitase in the cell division of old yeast mother cells. Exp Gerontol (2010) 1.11
Roles for sphingolipids in Saccharomyces cerevisiae. Adv Exp Med Biol (2010) 1.08
The genetics of aging in the yeast Saccharomyces cerevisiae. Genetica (1993) 1.07
Aup1-mediated regulation of Rtg3 during mitophagy. J Biol Chem (2009) 1.05
The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. J Biol Chem (2004) 1.03
Mitochondrial function is an inducible determinant of osmotic stress adaptation in yeast. J Biol Chem (2009) 1.03
Common and cell type-specific responses of human cells to mitochondrial dysfunction. Exp Cell Res (2005) 1.02
Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells. Free Radic Biol Med (2011) 1.01
Segregation of yeast nuclear pores. Nature (2010) 1.01