Published in Aging Cell on March 10, 2016
Arginase-II Deficiency Extends Lifespan in Mice. Front Physiol (2017) 0.75
Epigenetic regulation in cell senescence. J Mol Med (Berl) (2017) 0.75
Oxidative stress shortens telomeres. Trends Biochem Sci (2002) 9.48
The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (1999) 7.85
Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell (1999) 6.98
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature (2010) 5.02
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med (2006) 4.61
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell (2005) 4.36
Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol (2010) 3.27
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92
Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun (2013) 2.56
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene (2002) 2.55
Telomere length assessment: biomarker of chronic oxidative stress? Free Radic Biol Med (2007) 2.47
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc Natl Acad Sci U S A (2003) 2.39
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radic Biol Med (2000) 2.19
Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res (1998) 2.09
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell (2011) 2.07
Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. Atherosclerosis (2009) 1.96
Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining. Am J Pathol (2002) 1.95
Apoptosis and aging: role of p66Shc redox protein. Antioxid Redox Signal (2006) 1.94
A quantitative real-time PCR method for absolute telomere length. Biotechniques (2008) 1.77
Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol (2012) 1.74
Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett (1999) 1.69
Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1. Diabetes (2013) 1.65
Dyskeratosis congenita, stem cells and telomeres. Biochim Biophys Acta (2009) 1.62
Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell (2002) 1.44
The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury. Biochim Biophys Acta (2009) 1.22
P66Shc signals to age. Aging (Albany NY) (2009) 1.18
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proc Natl Acad Sci U S A (2007) 1.07
The Lifespan-regulator p66Shc in mitochondria: redox enzyme or redox sensor? Antioxid Redox Signal (2010) 1.06
The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell (2010) 1.03
Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres. J Cell Biol (2007) 1.03
Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation. Diabetologia (2007) 1.00
Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proc Natl Acad Sci U S A (2001) 1.00
At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways. Aging Cell (2010) 0.98
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice. Exp Gerontol (2006) 0.98
The p66Shc knocked out mice are short lived under natural condition. Aging Cell (2011) 0.97
p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice. Endothelium (2008) 0.96
Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. Eur J Neurosci (2012) 0.91
The influence of Shc proteins on life span in mice. J Gerontol A Biol Sci Med Sci (2013) 0.84
Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice. Aging (Albany NY) (2009) 0.83
Telomere length increase after weight loss induced by bariatric surgery: results from a 10 year prospective study. Int J Obes (Lond) (2015) 0.82
The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation. Free Radic Biol Med (2013) 0.82
p66Shc, mitochondria, and the generation of reactive oxygen species. Methods Enzymol (2013) 0.79
The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration. Oxid Med Cell Longev (2013) 0.79
Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema. PLoS One (2015) 0.78